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PDB: 88675 件

6GCG
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Copper nitrite reductase from Achromobacter cycloclastes: large polymorph dataset 15
分子名称: COPPER (II) ION, Copper-containing nitrite reductase
著者Ebrahim, A, Appleby, M.V, Axford, D, Beale, J, Moreno-Chicano, T, Sherrell, D.A, Strange, R.W, Owen, R.L, Hough, M.A.
登録日2018-04-17
公開日2019-01-30
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.80015242 Å)
主引用文献Resolving polymorphs and radiation-driven effects in microcrystals using fixed-target serial synchrotron crystallography.
Acta Crystallogr D Struct Biol, 75, 2019
5N5V
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Structure of p-boronophenylalanyl tRNA synthetase - apo form
分子名称: CHLORIDE ION, Tyrosine--tRNA ligase
著者Schiefner, A, Skerra, A.
登録日2017-02-14
公開日2018-02-14
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Structural Basis for the Specific Cotranslational Incorporation of p-Boronophenylalanine into Biosynthetic Proteins.
Biochemistry, 57, 2018
8P30
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Structure of human SIT1:ACE2 complex (open PD conformation) bound to L-pipecolate
分子名称: (2S)-piperidine-2-carboxylic acid, 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B.
登録日2023-05-16
公開日2024-06-12
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.29 Å)
主引用文献Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
7ZLL
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Catalytic domain of UDP-Glucose Glycoprotein Glucosyltransferase from Chaetomium thermophilum in complex with the 5-[(morpholin-4-yl)methyl]quinolin-8-ol inhibitor
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 5-(morpholin-4-ylmethyl)quinolin-8-ol, UDP-glucose-glycoprotein glucosyltransferase-like protein, ...
著者Roversi, P, Zitzmann, N, Bayo, Y, Kantsadi, A.L, Chandran, A.V.
登録日2022-04-15
公開日2023-04-26
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.649 Å)
主引用文献A quinolin-8-ol sub-millimolar inhibitor of UGGT, the ER glycoprotein folding quality control checkpoint.
Iscience, 26, 2023
6T0B
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BU of 6t0b by Molmil
The III2-IV(5B)2 respiratory supercomplex from S. cerevisiae
分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSHOCHOLINE, CALCIUM ION, CARDIOLIPIN, ...
著者Marechal, A, Pinotsis, N, Hartley, A.
登録日2019-10-02
公開日2020-04-22
最終更新日2020-05-06
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Rcf2 revealed in cryo-EM structures of hypoxic isoforms of mature mitochondrial III-IV supercomplexes.
Proc.Natl.Acad.Sci.USA, 117, 2020
6VRG
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BU of 6vrg by Molmil
Structure of HIV-1 integrase with native amino-terminal sequence
分子名称: Integrase, PHOSPHATE ION, POTASSIUM ION, ...
著者Eilers, G, Gupta, K, Allen, A, Zhou, J, Hwang, Y, Cory, M, Bushman, F.D, Van Duyne, G.D.
登録日2020-02-07
公開日2020-09-09
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Influence of the amino-terminal sequence on the structure and function of HIV integrase.
Retrovirology, 17, 2020
7ZS7
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BU of 7zs7 by Molmil
Crystal structure of human cathepsin L with covalently bound calpain inhibitor VI
分子名称: (2S)-2-[(4-fluorophenyl)sulfonylamino]-3-methyl-N-[(2S)-4-methyl-1-oxidanyl-pentan-2-yl]butanamide, ACETATE ION, Cathepsin L, ...
著者Falke, S, Lieske, J, Guenther, S, Reinke, P.Y.A, Ewert, W, Loboda, J, Karnicar, K, Usenik, A, Lindic, N, Sekirnik, A, Chapman, H.N, Hinrichs, W, Turk, D, Meents, A.
登録日2022-05-06
公開日2023-05-17
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献Structural Elucidation and Antiviral Activity of Covalent Cathepsin L Inhibitors.
J.Med.Chem., 2024
6NHK
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Mortalin nucleotide binding domain in the ADP-bound state
分子名称: ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, MAGNESIUM ION, ...
著者Page, R.C, Moseng, M.A, Nix, J.C.
登録日2018-12-23
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.777 Å)
主引用文献Biophysical Consequences of EVEN-PLUS Syndrome Mutations for the Function of Mortalin.
J.Phys.Chem.B, 123, 2019
7PCA
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BU of 7pca by Molmil
Functional and structural characterization of redox sensitive superfolder green fluorescent protein and variants
分子名称: ETHANOL, FORMAMIDE, GLYCEROL, ...
著者Fritz-Wolf, K, Heimsch, K.C, Schuh, A.K, Becker, K.
登録日2021-08-03
公開日2022-02-16
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.05 Å)
主引用文献Structure and Function of Redox-Sensitive Superfolder Green Fluorescent Protein Variant.
Antioxid.Redox Signal., 37, 2022
8P2X
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Structure of human SIT1:ACE2 complex (open PD conformation)
分子名称: 2-acetamido-2-deoxy-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Li, H.Z, Pike, A.C.W, Chi, G, Hansen, J.S, Lee, S.G, Rodstrom, K.E.J, Bushell, S.R, Speedman, D, Evans, A, Wang, D, He, D, Shrestha, L, Nasrallah, C, Chalk, R, Moreira, T, MacLean, E.M, Marsden, B, Bountra, C, Burgess-Brown, N.A, Dafforn, T.R, Carpenter, E.P, Sauer, D.B.
登録日2023-05-16
公開日2024-06-12
最終更新日2024-07-10
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.
Nat Commun, 15, 2024
7TFF
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BU of 7tff by Molmil
Crystal structure of human platelet phosphofructokinase-1 mutant- D564N
分子名称: ATP-dependent 6-phosphofructokinase, platelet type, PHOSPHATE ION, ...
著者Hansen, H, Webb, B.A, Robart, A.R, Narayanasami, S.
登録日2022-01-06
公開日2023-07-12
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Cancer-associated somatic mutations in human phosphofructokinase-1 reveal a critical electrostatic interaction for allosteric regulation of enzyme activity.
Biochem.J., 480, 2023
8DH6
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BU of 8dh6 by Molmil
Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid nanodiscs
分子名称: CALCIUM ION, COPPER (II) ION, Cytochrome c oxidase subunit 1, ...
著者Godoy, A.S, Song, Y, Cheruvara, H, Quigley, A, Oliva, G.
登録日2022-06-25
公開日2022-07-20
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (2.94 Å)
主引用文献Cryo-EM structure of Saccharomyces cerevisiae cytochrome c oxidase (Complex IV) extracted in lipid nanodiscs
To Be Published
6YJG
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Crystal structure of MINDY1 mutant-Y114F
分子名称: Ubiquitin carboxyl-terminal hydrolase MINDY1
著者Abdul Rehman, S.A, Kulathu, Y.
登録日2020-04-03
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.28 Å)
主引用文献Mechanism of activation and regulation of deubiquitinase activity in MINDY1 and MINDY2.
Mol.Cell, 81, 2021
6YKG
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BU of 6ykg by Molmil
Structure-based exploration of selectivity for ATM inhibitors in Huntingtons disease
分子名称: 4-morpholin-4-yl-6-[(2~{R})-2-(phenylmethyl)pyrrolidin-1-yl]-1~{H}-pyridin-2-one, Phosphatidylinositol 3-kinase catalytic subunit type 3
著者Van de Poel, A, Leonard, P.M, Lamers, M.B.A.C.
登録日2020-04-06
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.12 Å)
主引用文献Structure-Based Exploration of Selectivity for ATM Inhibitors in Huntington's Disease.
J.Med.Chem., 64, 2021
7TXA
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Structure of the Class II Fructose-1,6-Bisphophatase from Francisella tularensis complexed with native metal cofactor Mn++ and product F6P
分子名称: 6-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase, MANGANESE (II) ION
著者Abad-Zapatero, C, Selezneva, A.I.
登録日2022-02-08
公開日2023-06-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
Plos One, 18, 2023
7TXB
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Structure of the Class II Fructose-1,6-Bisphophatase from Mycobacterium tuberculosis complexed with substrate F1,6BP
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, Fructose-1,6-bisphosphatase class 2, GLYCEROL, ...
著者Abad-Zapatero, C, Selezneva, A.I, Gutka, H.J.
登録日2022-02-08
公開日2023-06-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (3.71 Å)
主引用文献New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
Plos One, 18, 2023
6YJ2
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BU of 6yj2 by Molmil
Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism
分子名称: GLYCEROL, Probable transcriptional regulatory protein (Probably TetR-family)
著者Keep, N.H, Pritchard, J.E, Sula, A, Cole, A.R, Kendall, S.L.
登録日2020-04-02
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism
To be published
6GAT
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BU of 6gat by Molmil
SOLUTION NMR STRUCTURE OF THE L22V MUTANT DNA BINDING DOMAIN OF AREA COMPLEXED TO A 13 BP DNA CONTAINING A TGATA SITE, REGULARIZED MEAN STRUCTURE
分子名称: DNA (5'-D(*CP*AP*GP*TP*GP*AP*TP*AP*GP*AP*GP*AP*C)-3'), DNA (5'-D(*GP*TP*CP*TP*CP*TP*AP*TP*CP*AP*CP*TP*G)-3'), NITROGEN REGULATORY PROTEIN AREA, ...
著者Clore, G.M, Starich, M, Wikstrom, M, Gronenborn, A.M.
登録日1997-11-07
公開日1998-01-28
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献The solution structure of the Leu22-->Val mutant AREA DNA binding domain complexed with a TGATAG core element defines a role for hydrophobic packing in the determination of specificity.
J.Mol.Biol., 277, 1998
7TXG
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Structure of the Class II Fructose-1,6-Bisphosphatase from Francisella tularensis with native Mn++ divalent cation and partially occupied product F6P
分子名称: Fructose-1,6-bisphosphatase, GLYCEROL, MANGANESE (II) ION, ...
著者Abad-Zapatero, C, Selezneva, A.I, Harding, L.N.M, Movahedzadeh, F.
登録日2022-02-09
公開日2023-06-28
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献New structures of Class II Fructose-1,6-Bisphosphatase from Francisella tularensis provide a framework for a novel catalytic mechanism for the entire class.
Plos One, 18, 2023
5N7M
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BU of 5n7m by Molmil
Protruding domain of GI.1 norovirus in complex with 2-fucosyllactose (2FL)
分子名称: 1,2-ETHANEDIOL, Capsid protein VP1, SODIUM ION, ...
著者Hansman, G.S, Koromyslova, A.D.
登録日2017-02-20
公開日2017-05-24
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.73 Å)
主引用文献Human norovirus inhibition by a human milk oligosaccharide.
Virology, 508, 2017
8DGL
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BU of 8dgl by Molmil
Crystal Structure of the RdfS Excisionase
分子名称: CHLORIDE ION, GLYCEROL, Recombination Directionality Factor RdfS
著者Verdonk, C.J, Ramsay, J.P, Marshall, A.C, Bond, C.S.
登録日2022-06-24
公開日2022-10-05
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Crystallographic and X-ray scattering study of RdfS, a recombination directionality factor from an integrative and conjugative element.
Acta Crystallogr D Struct Biol, 78, 2022
8D05
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Hallucinated C2 protein assembly HALC2_065
分子名称: HALC2_065
著者Ragotte, R.J, Bera, A.K, Wicky, B.I.M, Milles, L.F, Baker, D.
登録日2022-05-25
公開日2022-09-28
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.51 Å)
主引用文献Hallucinating symmetric protein assemblies.
Science, 378, 2022
6YL2
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BU of 6yl2 by Molmil
Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism
分子名称: DNA (5'-D(*AP*CP*GP*TP*TP*AP*AP*TP*GP*AP*CP*GP*AP*TP*TP*AP*AP*CP*CP*G)-3'), DNA (5'-D(*CP*GP*GP*TP*TP*AP*AP*TP*CP*GP*TP*CP*AP*TP*TP*AP*AP*CP*GP*T)-3'), Probable transcriptional regulatory protein (Probably TetR-family)
著者Keep, N.H, Pritchard, J.E, Sula, A, Cole, A.R, Kendall, S.L.
登録日2020-04-06
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (3.15 Å)
主引用文献Structural and DNA binding studies of the transcriptional repressor Rv2506 (BkaR) from Mycobacterium tuberculosis supports a role in L-Leucine catabolism
To be published
6RAV
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BU of 6rav by Molmil
Complement factor B protease domain in complex with the reversible inhibitor 4-((2S,4S)-4-ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic acid
分子名称: 4-[(2~{S},4~{S})-4-ethoxy-1-[(5-methoxy-7-methyl-1~{H}-indol-4-yl)methyl]piperidin-2-yl]benzoic acid, Complement factor B, SULFATE ION, ...
著者Adams, C.M, Sellner, H, Ehara, T, Mac Sweeney, A, Crowley, M, Anderson, K, Karki, R, Mainolfi, N, Valeur, E, Sirockin, F, Gerhartz, B, Erbel, P, Hughes, N, Smith, T.M, Cumin, F, Argikar, U, Mogi, M, Sedrani, R, Wiesmann, C, Jaffee, B, Maibaum, J, Flohr, S, Harrison, R, Eder, J.
登録日2019-04-08
公開日2019-04-17
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Proc.Natl.Acad.Sci.USA, 116, 2019
6YM1
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Mycobacterium tuberculosis FtsZ in complex with GDP
分子名称: Cell division protein FtsZ, GUANOSINE-5'-DIPHOSPHATE
著者Alnami, A.T, Norton, R.S, Pena, H.P, Haider, M, kozielski, F.
登録日2020-04-07
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Conformational Flexibility of A Highly Conserved Helix Controls Cryptic Pocket Formation in FtsZ.
J.Mol.Biol., 433, 2021

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