8P30

Structure of human SIT1:ACE2 complex (open PD conformation) bound to L-pipecolate

Summary for 8P30

• Entry DOI: 10.2210/pdb8p30/pdb
• EMDB information: 17381
• Descriptor: Processed angiotensin-converting enzyme 2, Sodium- and chloride-dependent transporter XTRP3, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (9 entities in total)
• Functional Keywords: amino acid transporter, proline, slc6a20, ace2, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 336479.62

Authors

Li, H.Z.,Pike, A.C.W.,Chi, G.,Hansen, J.S.,Lee, S.G.,Rodstrom, K.E.J.,Bushell, S.R.,Speedman, D.,Evans, A.,Wang, D.,He, D.,Shrestha, L.,Nasrallah, C.,Chalk, R.,Moreira, T.,MacLean, E.M.,Marsden, B.,Bountra, C.,Burgess-Brown, N.A.,Dafforn, T.R.,Carpenter, E.P.,Sauer, D.B. (deposition date: 2023-05-16, release date: 2024-06-12)

• Primary citation: Li, H.Z.,Pike, A.C.W.,Chi, G.,Hansen, J.S.,Lee, S.G.,Rodstrom, K.E.J.,Bushell, S.R.,Speedman, D.,Evans, A.,Wang, D.,He, D.,Shrestha, L.,Nasrallah, C.,Burgess-Brown, N.A.,Dafforn, T.R.,Carpenter, E.P.,Sauer, D.B.; Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2; TO BE CONFIRMED,

Experimental method

ELECTRON MICROSCOPY (3.29 Å)