5LF1
| Human 20S proteasome complex with Dihydroeponemycin at 2.0 Angstrom | 分子名称: | CHLORIDE ION, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... | 著者 | Schrader, J, Henneberg, F, Mata, R, Tittmann, K, Schneider, T.R, Stark, H, Bourenkov, G, Chari, A. | 登録日 | 2016-06-30 | 公開日 | 2016-08-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 2016
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8FYG
| Crystal structure of Hyaluronate lyase A from Cutibacterium acnes | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Hyaluronate lyase | 著者 | Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R. | 登録日 | 2023-01-26 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Functional divergence of a bacterial enzyme promotes healthy or acneic skin. Nat Commun, 14, 2023
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8AYI
| Scalindua brodae amxFabZ H48N mutant | 分子名称: | Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase | 著者 | Dietl, A, Barends, T. | 登録日 | 2022-09-02 | 公開日 | 2023-03-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference. J.Biol.Chem., 299, 2023
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5LHS
| The ligand free catalytic domain of murine urokinase-type plasminogen activator | 分子名称: | NICKEL (II) ION, SULFATE ION, Urokinase-type plasminogen activator | 著者 | Kromann-Hansen, T, Lange, E.L, Sorensen, H.P, Ghassabeh, G.H, Huang, M, Jensen, J.K, Muyldermans, S, Declerck, P.J, Andreasen, P.A. | 登録日 | 2016-07-12 | 公開日 | 2017-06-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.047 Å) | 主引用文献 | Discovery of a novel conformational equilibrium in urokinase-type plasminogen activator. Sci Rep, 7, 2017
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6UYD
| Structure of Hepatitis C Virus Envelope Glycoprotein E2mc3-v1 redesigned core from genotype 1a bound to broadly neutralizing antibody AR3C | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope glycoprotein E2, ... | 著者 | Tzarum, N, Wilson, I.A, Zhu, J. | 登録日 | 2019-11-13 | 公開日 | 2020-04-22 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.897 Å) | 主引用文献 | Proof of concept for rational design of hepatitis C virus E2 core nanoparticle vaccines. Sci Adv, 6, 2020
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6P3M
| Tetrahydroprotoberberine N-methyltransferase in complex with S-adenosylhomocysteine | 分子名称: | S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION, tetrahydroprotoberberine N-methyltransferase | 著者 | Lang, D.E, Morris, J.S, Rowley, M, Torres, M.A, Maksimovich, V.A, Facchini, P.J, Ng, K.K.S. | 登録日 | 2019-05-24 | 公開日 | 2019-08-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structure-function studies of tetrahydroprotoberberineN-methyltransferase reveal the molecular basis of stereoselective substrate recognition. J.Biol.Chem., 294, 2019
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8PT3
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6L3H
| Cryo-EM structure of dimeric quinol dependent Nitric Oxide Reductase (qNOR) from the pathogen Neisseria meninigitidis | 分子名称: | CALCIUM ION, FE (III) ION, Nitric-oxide reductase, ... | 著者 | Jamali, M.M.A, Gopalasingam, C.C, Johnson, R.M, Tosha, T, Muench, S.P, Muramoto, K, Antonyuk, S.V, Shiro, Y, Hasnain, S.S. | 登録日 | 2019-10-11 | 公開日 | 2020-04-01 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.06 Å) | 主引用文献 | The active form of quinol-dependent nitric oxide reductase fromNeisseria meningitidisis a dimer. Iucrj, 7, 2020
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6ZQI
| Cryo-EM structure of Spondweni virus prME | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Genome polyprotein | 著者 | Renner, M, Dejnirattisai, W, Carrique, L, Serna Martin, I, Karia, D, Ilca, S.L, Ho, S.F, Kotecha, A, Keown, J.R, Mongkolsapaya, J, Screaton, G.R, Grimes, J.M. | 登録日 | 2020-07-09 | 公開日 | 2021-01-20 | 最終更新日 | 2021-08-04 | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | 主引用文献 | Flavivirus maturation leads to the formation of an occupied lipid pocket in the surface glycoproteins. Nat Commun, 12, 2021
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6V0S
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6XLI
| CRYSTAL STRUCTURE OF ANTI-TAU ANTIBODY PT3 Fab+pT212/pT217-TAU PEPTIDE | 分子名称: | GLYCEROL, PT3 Fab Heavy Chain, PT3 Fab Light Chain, ... | 著者 | Malia, T.J, Teplyakov, A, Luo, J. | 登録日 | 2020-06-28 | 公開日 | 2020-09-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery and Functional Characterization of hPT3, a Humanized Anti-Phospho Tau Selective Monoclonal Antibody. J Alzheimers Dis, 77, 2020
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6E1V
| Crystal structure of a class I PreQ1 riboswitch complexed with a synthetic compound 3: 2-[(9H-carbazol-3-yl)oxy]-N,N-dimethylethan-1-amine | 分子名称: | 2-[(9H-carbazol-3-yl)oxy]-N,N-dimethylethan-1-amine, RNA (33-MER) | 著者 | Numata, T, Connelly, C.M, Schneekloth, J.S, Ferre-D'Amare, A.R. | 登録日 | 2018-07-10 | 公開日 | 2019-04-10 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.56 Å) | 主引用文献 | Synthetic ligands for PreQ1riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat Commun, 10, 2019
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6V0X
| Crystal structure of the bromodomain of human BRD9 bound to sunitinib | 分子名称: | Bromodomain-containing protein 9, N-[2-(diethylamino)ethyl]-5-[(Z)-(5-fluoro-2-oxo-1,2-dihydro-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-carbo xamide | 著者 | Karim, M.R, Chan, A, Zhu, J.Y, Schonbrunn, E. | 登録日 | 2019-11-19 | 公開日 | 2020-03-11 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Structural Basis of Inhibitor Selectivity in the BRD7/9 Subfamily of Bromodomains. J.Med.Chem., 63, 2020
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5LLP
| Crystal structure of human carbonic anhydrase isozyme XII with 3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide | 分子名称: | 3-[(1S)-1,2,3,4-Tetrahydronapthalen-1-ylamino)-2,5,6-trifluoro-4-[(2-hydroxyethyl)sulfonyl]benzenesulfonamide, Carbonic anhydrase 12, ZINC ION | 著者 | Smirnov, A, Manakova, E, Grazulis, S. | 登録日 | 2016-07-28 | 公開日 | 2017-08-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Crystal structure correlations with the intrinsic thermodynamics of human carbonic anhydrase inhibitor binding. PeerJ, 6, 2018
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6E0B
| Plasmodium falciparum dihydroorotate dehydrogenase C276F mutant bound with triazolopyrimidine-based inhibitor DSM1 | 分子名称: | 5-methyl-7-(naphthalen-2-ylamino)-1H-[1,2,4]triazolo[1,5-a]pyrimidine-3,8-diium, Dihydroorotate dehydrogenase (quinone), mitochondrial, ... | 著者 | Tomchick, D.R, Phillips, M.A, Deng, X. | 登録日 | 2018-07-06 | 公開日 | 2018-11-14 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.099 Å) | 主引用文献 | Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265. ACS Infect Dis, 5, 2019
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6XMK
| 1.70 A resolution structure of SARS-CoV-2 3CL protease in complex with inhibitor 7j | 分子名称: | (1S,2S)-2-[(N-{[(4,4-difluorocyclohexyl)methoxy]carbonyl}-L-leucyl)amino]-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, TETRAETHYLENE GLYCOL | 著者 | Lovell, S, Kashipathy, M.M, Battaile, K.P, Rathnayake, A.D, Zheng, J, Kim, Y, Nguyen, H.N, Chang, K.O, Groutas, W.C. | 登録日 | 2020-06-30 | 公開日 | 2020-07-08 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | 3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV-infected mice. Sci Transl Med, 12, 2020
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5F5A
| Crystal Structure of human JMJD2D complexed with KDOAM16 | 分子名称: | 1,2-ETHANEDIOL, 2-[(furan-2-ylmethylamino)methyl]pyridine-4-carboxylic acid, Lysine-specific demethylase 4D, ... | 著者 | Krojer, T, Vollmar, M, Crawley, L, Bradley, A.R, Szykowska, A, Ruda, G.F, Yang, H, Burgess-Brown, N, Brennan, P, Bountra, C, Arrowsmith, C.H, Edwards, A, Oppermann, U, von Delft, F, Structural Genomics Consortium (SGC) | 登録日 | 2015-12-04 | 公開日 | 2015-12-16 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.41 Å) | 主引用文献 | 8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors. J.Med.Chem., 59, 2016
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8G0O
| Crystal structure of Y281F mutant of Hyaluronate lyase B from Cutibacterium acnes | 分子名称: | Hyaluronate lyase | 著者 | Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R. | 登録日 | 2023-02-01 | 公開日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Functional divergence of a bacterial enzyme promotes healthy or acneic skin. Nat Commun, 14, 2023
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7LRM
| Structure of HIV-1 Reverse Transcriptase in complex with DNA, dCTP, and CA(2+) ion | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, CALCIUM ION, DNA/RNA (38-MER), ... | 著者 | Hoang, A, Ruiz, F.X, Arnold, E. | 登録日 | 2021-02-16 | 公開日 | 2022-02-23 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.14 Å) | 主引用文献 | Structural basis of HIV inhibition by L-nucleosides: Opportunities for drug development and repurposing. Drug Discov Today, 27, 2022
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4XDK
| Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in complex with norfluoxetine | 分子名称: | (3R)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, (3S)-3-phenyl-3-[4-(trifluoromethyl)phenoxy]propan-1-amine, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) | 登録日 | 2014-12-19 | 公開日 | 2015-03-18 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.6 Å) | 主引用文献 | K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science, 347, 2015
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6UZB
| Anthrax toxin protective antigen channels bound to edema factor | 分子名称: | CALCIUM ION, Calmodulin-sensitive adenylate cyclase, Protective antigen | 著者 | Hardenbrook, N.J, Liu, S, Zhou, K, Zhou, Z.H, Krantz, B.A. | 登録日 | 2019-11-14 | 公開日 | 2020-03-04 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Atomic structures of anthrax toxin protective antigen channels bound to partially unfolded lethal and edema factors. Nat Commun, 11, 2020
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6XP3
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4E8V
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5EW9
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6E1W
| Crystal structure of a class I PreQ1 riboswitch complexed with PreQ1 | 分子名称: | 2-amino-5-(aminomethyl)-1,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, ACETATE ION, MAGNESIUM ION, ... | 著者 | Numata, T, Connelly, C.M, Schneekloth, J.S, Ferre-D'Amare, A.R. | 登録日 | 2018-07-10 | 公開日 | 2019-04-10 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Synthetic ligands for PreQ1riboswitches provide structural and mechanistic insights into targeting RNA tertiary structure. Nat Commun, 10, 2019
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