5LF1

Human 20S proteasome complex with Dihydroeponemycin at 2.0 Angstrom

Summary for 5LF1

Entry DOI	10.2210/pdb5lf1/pdb
Descriptor	Proteasome subunit alpha type-2, Proteasome subunit beta type-2, Proteasome subunit beta type-5, ... (20 entities in total)
Functional Keywords	proteasome, multicatalytic proteinase, ntn-hydrolase, hydrolase
Biological source	Homo sapiens (Human) More
Cellular location	Cytoplasm : P25787 P49721 P28074 P20618 P28070 P28072 P25789 O14818 P28066 P25786 P25788 P60900 Q99436 P49720
Total number of polymer chains	28
Total formula weight	726015.29
Authors	Schrader, J.,Henneberg, F.,Mata, R.,Tittmann, K.,Schneider, T.R.,Stark, H.,Bourenkov, G.,Chari, A. (deposition date: 2016-06-30, release date: 2016-08-17, Last modification date: 2024-01-10)
Primary citation	Schrader, J.,Henneberg, F.,Mata, R.A.,Tittmann, K.,Schneider, T.R.,Stark, H.,Bourenkov, G.,Chari, A. The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353:594-598, 2016 Cited by PubMed: 27493187 DOI: 10.1126/science.aaf8993 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2 Å)

Structure validation