5LF1
Human 20S proteasome complex with Dihydroeponemycin at 2.0 Angstrom
Functional Information from GO Data
Chain | GOid | namespace | contents |
a | 0005839 | cellular_component | proteasome core complex |
a | 0051603 | biological_process | proteolysis involved in protein catabolic process |
A | 0000502 | cellular_component | proteasome complex |
A | 0000932 | cellular_component | P-body |
A | 0005515 | molecular_function | protein binding |
A | 0005576 | cellular_component | extracellular region |
A | 0005634 | cellular_component | nucleus |
A | 0005654 | cellular_component | nucleoplasm |
A | 0005737 | cellular_component | cytoplasm |
A | 0005829 | cellular_component | cytosol |
A | 0005839 | cellular_component | proteasome core complex |
A | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
A | 0009615 | biological_process | response to virus |
A | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
A | 0034774 | cellular_component | secretory granule lumen |
A | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
A | 0051603 | biological_process | proteolysis involved in protein catabolic process |
A | 0070062 | cellular_component | extracellular exosome |
A | 1904813 | cellular_component | ficolin-1-rich granule lumen |
b | 0004298 | molecular_function | threonine-type endopeptidase activity |
b | 0005839 | cellular_component | proteasome core complex |
b | 0051603 | biological_process | proteolysis involved in protein catabolic process |
B | 0000502 | cellular_component | proteasome complex |
B | 0000932 | cellular_component | P-body |
B | 0005515 | molecular_function | protein binding |
B | 0005634 | cellular_component | nucleus |
B | 0005654 | cellular_component | nucleoplasm |
B | 0005737 | cellular_component | cytoplasm |
B | 0005829 | cellular_component | cytosol |
B | 0005839 | cellular_component | proteasome core complex |
B | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
B | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
B | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
B | 0051603 | biological_process | proteolysis involved in protein catabolic process |
B | 0070062 | cellular_component | extracellular exosome |
C | 0000502 | cellular_component | proteasome complex |
C | 0005515 | molecular_function | protein binding |
C | 0005634 | cellular_component | nucleus |
C | 0005654 | cellular_component | nucleoplasm |
C | 0005737 | cellular_component | cytoplasm |
C | 0005829 | cellular_component | cytosol |
C | 0005839 | cellular_component | proteasome core complex |
C | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
C | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
C | 0042802 | molecular_function | identical protein binding |
C | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
C | 0051603 | biological_process | proteolysis involved in protein catabolic process |
C | 0070062 | cellular_component | extracellular exosome |
C | 0098794 | cellular_component | postsynapse |
D | 0000502 | cellular_component | proteasome complex |
D | 0005515 | molecular_function | protein binding |
D | 0005576 | cellular_component | extracellular region |
D | 0005634 | cellular_component | nucleus |
D | 0005654 | cellular_component | nucleoplasm |
D | 0005737 | cellular_component | cytoplasm |
D | 0005829 | cellular_component | cytosol |
D | 0005839 | cellular_component | proteasome core complex |
D | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
D | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
D | 0034774 | cellular_component | secretory granule lumen |
D | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
D | 0051603 | biological_process | proteolysis involved in protein catabolic process |
D | 0070062 | cellular_component | extracellular exosome |
D | 1904813 | cellular_component | ficolin-1-rich granule lumen |
E | 0000502 | cellular_component | proteasome complex |
E | 0001530 | molecular_function | lipopolysaccharide binding |
E | 0002376 | biological_process | immune system process |
E | 0002862 | biological_process | negative regulation of inflammatory response to antigenic stimulus |
E | 0005515 | molecular_function | protein binding |
E | 0005634 | cellular_component | nucleus |
E | 0005654 | cellular_component | nucleoplasm |
E | 0005737 | cellular_component | cytoplasm |
E | 0005813 | cellular_component | centrosome |
E | 0005829 | cellular_component | cytosol |
E | 0005839 | cellular_component | proteasome core complex |
E | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
E | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
E | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
E | 0051603 | biological_process | proteolysis involved in protein catabolic process |
E | 0070062 | cellular_component | extracellular exosome |
F | 0000502 | cellular_component | proteasome complex |
F | 0005515 | molecular_function | protein binding |
F | 0005634 | cellular_component | nucleus |
F | 0005654 | cellular_component | nucleoplasm |
F | 0005737 | cellular_component | cytoplasm |
F | 0005829 | cellular_component | cytosol |
F | 0005839 | cellular_component | proteasome core complex |
F | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
F | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
F | 0031625 | molecular_function | ubiquitin protein ligase binding |
F | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
F | 0045202 | cellular_component | synapse |
F | 0051603 | biological_process | proteolysis involved in protein catabolic process |
F | 0052548 | biological_process | regulation of endopeptidase activity |
F | 0070062 | cellular_component | extracellular exosome |
G | 0000502 | cellular_component | proteasome complex |
G | 0000932 | cellular_component | P-body |
G | 0003723 | molecular_function | RNA binding |
G | 0004175 | molecular_function | endopeptidase activity |
G | 0005515 | molecular_function | protein binding |
G | 0005634 | cellular_component | nucleus |
G | 0005654 | cellular_component | nucleoplasm |
G | 0005737 | cellular_component | cytoplasm |
G | 0005829 | cellular_component | cytosol |
G | 0005839 | cellular_component | proteasome core complex |
G | 0005840 | cellular_component | ribosome |
G | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
G | 0016363 | cellular_component | nuclear matrix |
G | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
G | 0030016 | cellular_component | myofibril |
G | 0030017 | cellular_component | sarcomere |
G | 0035639 | molecular_function | purine ribonucleoside triphosphate binding |
G | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
G | 0050727 | biological_process | regulation of inflammatory response |
G | 0051059 | molecular_function | NF-kappaB binding |
G | 0051092 | biological_process | positive regulation of NF-kappaB transcription factor activity |
G | 0051603 | biological_process | proteolysis involved in protein catabolic process |
G | 0070062 | cellular_component | extracellular exosome |
H | 0004298 | molecular_function | threonine-type endopeptidase activity |
H | 0005839 | cellular_component | proteasome core complex |
H | 0051603 | biological_process | proteolysis involved in protein catabolic process |
I | 0000502 | cellular_component | proteasome complex |
I | 0005515 | molecular_function | protein binding |
I | 0005634 | cellular_component | nucleus |
I | 0005654 | cellular_component | nucleoplasm |
I | 0005737 | cellular_component | cytoplasm |
I | 0005829 | cellular_component | cytosol |
I | 0005839 | cellular_component | proteasome core complex |
I | 0019774 | cellular_component | proteasome core complex, beta-subunit complex |
I | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
I | 0051603 | biological_process | proteolysis involved in protein catabolic process |
I | 0070062 | cellular_component | extracellular exosome |
J | 0000502 | cellular_component | proteasome complex |
J | 0005515 | molecular_function | protein binding |
J | 0005634 | cellular_component | nucleus |
J | 0005654 | cellular_component | nucleoplasm |
J | 0005737 | cellular_component | cytoplasm |
J | 0005829 | cellular_component | cytosol |
J | 0005839 | cellular_component | proteasome core complex |
J | 0010243 | biological_process | response to organonitrogen compound |
J | 0010498 | biological_process | proteasomal protein catabolic process |
J | 0014070 | biological_process | response to organic cyclic compound |
J | 0016020 | cellular_component | membrane |
J | 0019774 | cellular_component | proteasome core complex, beta-subunit complex |
J | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
J | 0051603 | biological_process | proteolysis involved in protein catabolic process |
J | 0070062 | cellular_component | extracellular exosome |
K | 0004298 | molecular_function | threonine-type endopeptidase activity |
K | 0005839 | cellular_component | proteasome core complex |
K | 0051603 | biological_process | proteolysis involved in protein catabolic process |
L | 0005839 | cellular_component | proteasome core complex |
L | 0051603 | biological_process | proteolysis involved in protein catabolic process |
M | 0005839 | cellular_component | proteasome core complex |
M | 0051603 | biological_process | proteolysis involved in protein catabolic process |
N | 0004298 | molecular_function | threonine-type endopeptidase activity |
N | 0005839 | cellular_component | proteasome core complex |
N | 0051603 | biological_process | proteolysis involved in protein catabolic process |
O | 0000502 | cellular_component | proteasome complex |
O | 0000932 | cellular_component | P-body |
O | 0005515 | molecular_function | protein binding |
O | 0005576 | cellular_component | extracellular region |
O | 0005634 | cellular_component | nucleus |
O | 0005654 | cellular_component | nucleoplasm |
O | 0005737 | cellular_component | cytoplasm |
O | 0005829 | cellular_component | cytosol |
O | 0005839 | cellular_component | proteasome core complex |
O | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
O | 0009615 | biological_process | response to virus |
O | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
O | 0034774 | cellular_component | secretory granule lumen |
O | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
O | 0051603 | biological_process | proteolysis involved in protein catabolic process |
O | 0070062 | cellular_component | extracellular exosome |
O | 1904813 | cellular_component | ficolin-1-rich granule lumen |
P | 0000502 | cellular_component | proteasome complex |
P | 0000932 | cellular_component | P-body |
P | 0005515 | molecular_function | protein binding |
P | 0005634 | cellular_component | nucleus |
P | 0005654 | cellular_component | nucleoplasm |
P | 0005737 | cellular_component | cytoplasm |
P | 0005829 | cellular_component | cytosol |
P | 0005839 | cellular_component | proteasome core complex |
P | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
P | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
P | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
P | 0043231 | cellular_component | intracellular membrane-bounded organelle |
P | 0051603 | biological_process | proteolysis involved in protein catabolic process |
P | 0070062 | cellular_component | extracellular exosome |
Q | 0000502 | cellular_component | proteasome complex |
Q | 0005515 | molecular_function | protein binding |
Q | 0005634 | cellular_component | nucleus |
Q | 0005654 | cellular_component | nucleoplasm |
Q | 0005737 | cellular_component | cytoplasm |
Q | 0005829 | cellular_component | cytosol |
Q | 0005839 | cellular_component | proteasome core complex |
Q | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
Q | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
Q | 0042802 | molecular_function | identical protein binding |
Q | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
Q | 0051603 | biological_process | proteolysis involved in protein catabolic process |
Q | 0070062 | cellular_component | extracellular exosome |
Q | 0098794 | cellular_component | postsynapse |
R | 0000502 | cellular_component | proteasome complex |
R | 0005515 | molecular_function | protein binding |
R | 0005576 | cellular_component | extracellular region |
R | 0005634 | cellular_component | nucleus |
R | 0005654 | cellular_component | nucleoplasm |
R | 0005737 | cellular_component | cytoplasm |
R | 0005829 | cellular_component | cytosol |
R | 0005839 | cellular_component | proteasome core complex |
R | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
R | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
R | 0034774 | cellular_component | secretory granule lumen |
R | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
R | 0051603 | biological_process | proteolysis involved in protein catabolic process |
R | 0070062 | cellular_component | extracellular exosome |
R | 1904813 | cellular_component | ficolin-1-rich granule lumen |
S | 0000502 | cellular_component | proteasome complex |
S | 0001530 | molecular_function | lipopolysaccharide binding |
S | 0002376 | biological_process | immune system process |
S | 0002862 | biological_process | negative regulation of inflammatory response to antigenic stimulus |
S | 0005515 | molecular_function | protein binding |
S | 0005634 | cellular_component | nucleus |
S | 0005654 | cellular_component | nucleoplasm |
S | 0005737 | cellular_component | cytoplasm |
S | 0005813 | cellular_component | centrosome |
S | 0005829 | cellular_component | cytosol |
S | 0005839 | cellular_component | proteasome core complex |
S | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
S | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
S | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
S | 0051603 | biological_process | proteolysis involved in protein catabolic process |
S | 0070062 | cellular_component | extracellular exosome |
T | 0000502 | cellular_component | proteasome complex |
T | 0005515 | molecular_function | protein binding |
T | 0005634 | cellular_component | nucleus |
T | 0005654 | cellular_component | nucleoplasm |
T | 0005737 | cellular_component | cytoplasm |
T | 0005829 | cellular_component | cytosol |
T | 0005839 | cellular_component | proteasome core complex |
T | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
T | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
T | 0031625 | molecular_function | ubiquitin protein ligase binding |
T | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
T | 0045202 | cellular_component | synapse |
T | 0051603 | biological_process | proteolysis involved in protein catabolic process |
T | 0052548 | biological_process | regulation of endopeptidase activity |
T | 0070062 | cellular_component | extracellular exosome |
U | 0000502 | cellular_component | proteasome complex |
U | 0000932 | cellular_component | P-body |
U | 0003723 | molecular_function | RNA binding |
U | 0004175 | molecular_function | endopeptidase activity |
U | 0005515 | molecular_function | protein binding |
U | 0005634 | cellular_component | nucleus |
U | 0005654 | cellular_component | nucleoplasm |
U | 0005737 | cellular_component | cytoplasm |
U | 0005829 | cellular_component | cytosol |
U | 0005839 | cellular_component | proteasome core complex |
U | 0005840 | cellular_component | ribosome |
U | 0006511 | biological_process | ubiquitin-dependent protein catabolic process |
U | 0016363 | cellular_component | nuclear matrix |
U | 0019773 | cellular_component | proteasome core complex, alpha-subunit complex |
U | 0030016 | cellular_component | myofibril |
U | 0030017 | cellular_component | sarcomere |
U | 0035639 | molecular_function | purine ribonucleoside triphosphate binding |
U | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
U | 0050727 | biological_process | regulation of inflammatory response |
U | 0051059 | molecular_function | NF-kappaB binding |
U | 0051092 | biological_process | positive regulation of NF-kappaB transcription factor activity |
U | 0051603 | biological_process | proteolysis involved in protein catabolic process |
U | 0070062 | cellular_component | extracellular exosome |
V | 0004298 | molecular_function | threonine-type endopeptidase activity |
V | 0005839 | cellular_component | proteasome core complex |
V | 0051603 | biological_process | proteolysis involved in protein catabolic process |
W | 0000502 | cellular_component | proteasome complex |
W | 0005515 | molecular_function | protein binding |
W | 0005634 | cellular_component | nucleus |
W | 0005654 | cellular_component | nucleoplasm |
W | 0005737 | cellular_component | cytoplasm |
W | 0005829 | cellular_component | cytosol |
W | 0005839 | cellular_component | proteasome core complex |
W | 0019774 | cellular_component | proteasome core complex, beta-subunit complex |
W | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
W | 0051603 | biological_process | proteolysis involved in protein catabolic process |
W | 0070062 | cellular_component | extracellular exosome |
X | 0000502 | cellular_component | proteasome complex |
X | 0005515 | molecular_function | protein binding |
X | 0005634 | cellular_component | nucleus |
X | 0005654 | cellular_component | nucleoplasm |
X | 0005737 | cellular_component | cytoplasm |
X | 0005829 | cellular_component | cytosol |
X | 0005839 | cellular_component | proteasome core complex |
X | 0010243 | biological_process | response to organonitrogen compound |
X | 0010498 | biological_process | proteasomal protein catabolic process |
X | 0014070 | biological_process | response to organic cyclic compound |
X | 0016020 | cellular_component | membrane |
X | 0019774 | cellular_component | proteasome core complex, beta-subunit complex |
X | 0043161 | biological_process | proteasome-mediated ubiquitin-dependent protein catabolic process |
X | 0051603 | biological_process | proteolysis involved in protein catabolic process |
X | 0070062 | cellular_component | extracellular exosome |
Y | 0004298 | molecular_function | threonine-type endopeptidase activity |
Y | 0005839 | cellular_component | proteasome core complex |
Y | 0051603 | biological_process | proteolysis involved in protein catabolic process |
Z | 0005839 | cellular_component | proteasome core complex |
Z | 0051603 | biological_process | proteolysis involved in protein catabolic process |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 4 |
Details | binding site for residue CL A 301 |
Chain | Residue |
A | SER6 |
A | HOH449 |
C | ARG5 |
C | HOH430 |
site_id | AC2 |
Number of Residues | 1 |
Details | binding site for residue CL A 302 |
Chain | Residue |
A | ARG219 |
site_id | AC3 |
Number of Residues | 3 |
Details | binding site for residue CL A 303 |
Chain | Residue |
A | HIS87 |
A | ARG90 |
H | HOH495 |
site_id | AC4 |
Number of Residues | 1 |
Details | binding site for residue CL A 304 |
Chain | Residue |
A | HOH446 |
site_id | AC5 |
Number of Residues | 5 |
Details | binding site for residue CL B 301 |
Chain | Residue |
B | GLU70 |
B | GLN95 |
B | CL302 |
B | HOH490 |
I | HOH544 |
site_id | AC6 |
Number of Residues | 2 |
Details | binding site for residue CL B 302 |
Chain | Residue |
B | CL301 |
B | HOH462 |
site_id | AC7 |
Number of Residues | 2 |
Details | binding site for residue CL C 301 |
Chain | Residue |
C | ILE161 |
C | GLY162 |
site_id | AC8 |
Number of Residues | 3 |
Details | binding site for residue CL C 302 |
Chain | Residue |
C | ARG86 |
C | ARG117 |
C | HOH435 |
site_id | AC9 |
Number of Residues | 4 |
Details | binding site for residue CL D 301 |
Chain | Residue |
D | ILE31 |
D | ILE170 |
D | GLY171 |
D | SER174 |
site_id | AD1 |
Number of Residues | 4 |
Details | binding site for residue CL E 301 |
Chain | Residue |
E | ILE161 |
E | GLY162 |
E | SER165 |
E | HOH522 |
site_id | AD2 |
Number of Residues | 2 |
Details | binding site for residue CL E 302 |
Chain | Residue |
E | 6V1148 |
E | SER150 |
site_id | AD3 |
Number of Residues | 4 |
Details | binding site for residue CL E 303 |
Chain | Residue |
D | THR161 |
D | HOH428 |
E | LEU77 |
E | THR78 |
site_id | AD4 |
Number of Residues | 4 |
Details | binding site for residue CL E 304 |
Chain | Residue |
E | GLY32 |
E | SER33 |
E | LYS62 |
E | GLY76 |
site_id | AD5 |
Number of Residues | 6 |
Details | binding site for residue CL F 301 |
Chain | Residue |
F | VAL30 |
F | ILE165 |
F | GLY166 |
F | ARG169 |
F | HOH402 |
F | HOH450 |
site_id | AD6 |
Number of Residues | 3 |
Details | binding site for residue CL G 301 |
Chain | Residue |
G | HOH434 |
G | HOH463 |
N | HOH436 |
site_id | AD7 |
Number of Residues | 4 |
Details | binding site for residue CL G 302 |
Chain | Residue |
G | LYS186 |
G | GLU192 |
G | GLN193 |
G | THR197 |
site_id | AD8 |
Number of Residues | 5 |
Details | binding site for residue K G 303 |
Chain | Residue |
G | THR14 |
G | TYR125 |
G | ASN128 |
G | MET131 |
G | HOH480 |
site_id | AD9 |
Number of Residues | 7 |
Details | binding site for residue MG H 301 |
Chain | Residue |
H | GLN91 |
H | HOH478 |
H | HOH536 |
N | ASP51 |
N | HOH402 |
N | HOH429 |
N | HOH491 |
site_id | AE1 |
Number of Residues | 5 |
Details | binding site for residue MG H 302 |
Chain | Residue |
H | ILE163 |
H | ASP166 |
H | SER169 |
H | HOH513 |
Z | ASP213 |
site_id | AE2 |
Number of Residues | 5 |
Details | binding site for residue CL H 303 |
Chain | Residue |
H | ASN80 |
H | ARG81 |
H | HOH514 |
H | HOH539 |
N | HOH430 |
site_id | AE3 |
Number of Residues | 4 |
Details | binding site for residue 1PE H 304 |
Chain | Residue |
H | LEU58 |
H | TYR90 |
I | TYR95 |
I | GLU96 |
site_id | AE4 |
Number of Residues | 15 |
Details | binding site for residue 6VC H 305 |
Chain | Residue |
H | THR1 |
H | ARG19 |
H | ALA20 |
H | THR21 |
H | CYS31 |
H | GLY47 |
H | ALA49 |
H | THR52 |
H | SER129 |
H | GLY168 |
H | HOH413 |
H | HOH423 |
I | ASP124 |
I | CYS128 |
I | HOH417 |
site_id | AE5 |
Number of Residues | 5 |
Details | binding site for residue MG I 301 |
Chain | Residue |
I | VAL174 |
I | ASP177 |
I | SER180 |
I | HOH411 |
I | HOH487 |
site_id | AE6 |
Number of Residues | 2 |
Details | binding site for residue CL I 302 |
Chain | Residue |
I | ARG69 |
I | ARG65 |
site_id | AE7 |
Number of Residues | 3 |
Details | binding site for residue 1PE I 303 |
Chain | Residue |
I | GLU96 |
I | LYS97 |
J | ASP90 |
site_id | AE8 |
Number of Residues | 5 |
Details | binding site for residue MG I 304 |
Chain | Residue |
I | ASP204 |
Y | THR164 |
Y | ASP167 |
Y | SER170 |
Y | HOH485 |
site_id | AE9 |
Number of Residues | 6 |
Details | binding site for residue MG J 301 |
Chain | Residue |
J | HOH412 |
J | HOH470 |
J | HOH473 |
J | HOH516 |
J | HOH528 |
K | HOH489 |
site_id | AF1 |
Number of Residues | 5 |
Details | binding site for residue MG K 301 |
Chain | Residue |
K | THR164 |
K | ASP167 |
K | SER170 |
W | ASP204 |
W | HOH461 |
site_id | AF2 |
Number of Residues | 3 |
Details | binding site for residue CL K 302 |
Chain | Residue |
K | GLY129 |
K | SER130 |
K | 6VC306 |
site_id | AF3 |
Number of Residues | 2 |
Details | binding site for residue CL K 303 |
Chain | Residue |
K | LYS32 |
K | ASN175 |
site_id | AF4 |
Number of Residues | 3 |
Details | binding site for residue CL K 304 |
Chain | Residue |
K | TYR66 |
K | ARG69 |
K | HOH462 |
site_id | AF5 |
Number of Residues | 2 |
Details | binding site for residue CL K 305 |
Chain | Residue |
K | ILE121 |
K | SER122 |
site_id | AF6 |
Number of Residues | 12 |
Details | binding site for residue 6VC K 306 |
Chain | Residue |
K | THR1 |
K | ARG19 |
K | ALA20 |
K | THR21 |
K | GLY47 |
K | ALA49 |
K | SER130 |
K | TYR169 |
K | CL302 |
K | HOH417 |
K | HOH436 |
L | HOH418 |
site_id | AF7 |
Number of Residues | 4 |
Details | binding site for residue 1PE L 301 |
Chain | Residue |
K | PHE54 |
L | SER98 |
L | PHE101 |
L | HOH462 |
site_id | AF8 |
Number of Residues | 5 |
Details | binding site for residue K L 302 |
Chain | Residue |
L | ALA183 |
L | ASP186 |
L | THR189 |
L | HOH446 |
L | HOH455 |
site_id | AF9 |
Number of Residues | 5 |
Details | binding site for residue MG L 303 |
Chain | Residue |
L | ASP213 |
L | HOH493 |
V | ILE163 |
V | ASP166 |
V | SER169 |
site_id | AG1 |
Number of Residues | 4 |
Details | binding site for residue CL M 301 |
Chain | Residue |
M | PHE36 |
M | ARG37 |
M | ASN38 |
N | HOH471 |
site_id | AG2 |
Number of Residues | 4 |
Details | binding site for residue CL M 302 |
Chain | Residue |
M | ARG35 |
N | PRO115 |
N | MET116 |
N | CL303 |
site_id | AG3 |
Number of Residues | 2 |
Details | binding site for residue CL M 303 |
Chain | Residue |
M | MET43 |
M | ARG44 |
site_id | AG4 |
Number of Residues | 3 |
Details | binding site for residue 1PE M 304 |
Chain | Residue |
M | TYR141 |
M | TYR144 |
b | THR22 |
site_id | AG5 |
Number of Residues | 3 |
Details | binding site for residue CL N 301 |
Chain | Residue |
N | THR31 |
N | ARG45 |
N | GLN53 |
site_id | AG6 |
Number of Residues | 4 |
Details | binding site for residue CL N 302 |
Chain | Residue |
N | GLY129 |
N | SER130 |
N | 6VC307 |
N | HOH440 |
site_id | AG7 |
Number of Residues | 6 |
Details | binding site for residue CL N 303 |
Chain | Residue |
M | ARG35 |
M | CL302 |
N | SER46 |
N | GLY97 |
N | GLY128 |
N | GLY129 |
site_id | AG8 |
Number of Residues | 5 |
Details | binding site for residue CL N 304 |
Chain | Residue |
N | ARG19 |
N | ARG29 |
N | GLY171 |
N | GLY172 |
a | HOH431 |
site_id | AG9 |
Number of Residues | 6 |
Details | binding site for residue 1PE N 305 |
Chain | Residue |
G | TYR103 |
H | GLN91 |
N | TYR90 |
N | HOH465 |
N | HOH469 |
N | HOH498 |
site_id | AH1 |
Number of Residues | 6 |
Details | binding site for residue K N 306 |
Chain | Residue |
N | MET164 |
N | ASP167 |
N | SER170 |
N | HOH439 |
N | HOH464 |
N | HOH546 |
site_id | AH2 |
Number of Residues | 16 |
Details | binding site for residue 6VC N 307 |
Chain | Residue |
H | TYR114 |
N | THR1 |
N | ARG19 |
N | THR20 |
N | THR21 |
N | THR22 |
N | ARG45 |
N | SER46 |
N | GLY47 |
N | ALA49 |
N | THR52 |
N | SER130 |
N | SER169 |
N | CL302 |
N | HOH470 |
N | HOH483 |
site_id | AH3 |
Number of Residues | 2 |
Details | binding site for residue CL O 301 |
Chain | Residue |
O | SER6 |
Q | HOH443 |
site_id | AH4 |
Number of Residues | 1 |
Details | binding site for residue CL O 302 |
Chain | Residue |
O | TYR100 |
site_id | AH5 |
Number of Residues | 2 |
Details | binding site for residue CL O 303 |
Chain | Residue |
O | ARG218 |
O | ARG219 |
site_id | AH6 |
Number of Residues | 1 |
Details | binding site for residue CL O 304 |
Chain | Residue |
O | ARG90 |
site_id | AH7 |
Number of Residues | 3 |
Details | binding site for residue CL P 301 |
Chain | Residue |
P | GLU70 |
P | GLN95 |
P | HOH513 |
site_id | AH8 |
Number of Residues | 1 |
Details | binding site for residue CL Q 301 |
Chain | Residue |
Q | ARG95 |
site_id | AH9 |
Number of Residues | 3 |
Details | binding site for residue CL Q 302 |
Chain | Residue |
Q | ILE161 |
Q | GLY162 |
Q | HOH408 |
site_id | AI1 |
Number of Residues | 6 |
Details | binding site for residue CL R 301 |
Chain | Residue |
R | ILE31 |
R | ILE170 |
R | GLY171 |
R | SER174 |
R | HOH488 |
R | HOH506 |
site_id | AI2 |
Number of Residues | 3 |
Details | binding site for residue CL R 302 |
Chain | Residue |
R | THR161 |
R | HOH456 |
S | THR78 |
site_id | AI3 |
Number of Residues | 5 |
Details | binding site for residue CL S 301 |
Chain | Residue |
S | 6V1148 |
S | ILE161 |
S | GLY162 |
S | SER165 |
S | HOH503 |
site_id | AI4 |
Number of Residues | 3 |
Details | binding site for residue CL S 302 |
Chain | Residue |
S | SER150 |
S | ASN152 |
S | HOH406 |
site_id | AI5 |
Number of Residues | 4 |
Details | binding site for residue CL S 303 |
Chain | Residue |
S | GLY32 |
S | LYS62 |
S | ALA75 |
S | GLY76 |
site_id | AI6 |
Number of Residues | 4 |
Details | binding site for residue CL U 301 |
Chain | Residue |
U | LYS102 |
U | HOH427 |
U | HOH431 |
b | HOH449 |
site_id | AI7 |
Number of Residues | 4 |
Details | binding site for residue 1PE U 302 |
Chain | Residue |
U | TYR103 |
U | HOH498 |
V | PHE88 |
b | TYR90 |
site_id | AI8 |
Number of Residues | 5 |
Details | binding site for residue K U 303 |
Chain | Residue |
U | THR14 |
U | TYR125 |
U | ASN128 |
U | MET131 |
U | HOH462 |
site_id | AI9 |
Number of Residues | 7 |
Details | binding site for residue MG V 301 |
Chain | Residue |
V | GLN91 |
V | HOH490 |
b | ASP93 |
b | HOH425 |
b | HOH430 |
b | HOH446 |
b | HOH491 |
site_id | AJ1 |
Number of Residues | 2 |
Details | binding site for residue CL V 302 |
Chain | Residue |
V | ASN80 |
V | ARG81 |
site_id | AJ2 |
Number of Residues | 5 |
Details | binding site for residue MG W 301 |
Chain | Residue |
W | VAL174 |
W | ASP177 |
W | SER180 |
W | HOH459 |
W | HOH472 |
site_id | AJ3 |
Number of Residues | 2 |
Details | binding site for residue CL W 302 |
Chain | Residue |
W | ARG65 |
W | ARG69 |
site_id | AJ4 |
Number of Residues | 4 |
Details | binding site for residue 1PE W 303 |
Chain | Residue |
W | GLU96 |
W | LYS97 |
W | HOH451 |
X | ASP90 |
site_id | AJ5 |
Number of Residues | 6 |
Details | binding site for residue MG X 301 |
Chain | Residue |
X | HOH418 |
X | HOH445 |
X | HOH449 |
X | HOH512 |
X | HOH522 |
Y | HOH519 |
site_id | AJ6 |
Number of Residues | 3 |
Details | binding site for residue CL Y 301 |
Chain | Residue |
Y | GLY129 |
Y | SER130 |
Y | 6VC306 |
site_id | AJ7 |
Number of Residues | 3 |
Details | binding site for residue CL Y 302 |
Chain | Residue |
Y | TYR66 |
Y | ARG69 |
Y | HOH504 |
site_id | AJ8 |
Number of Residues | 2 |
Details | binding site for residue CL Y 303 |
Chain | Residue |
Y | LYS32 |
Y | ASN175 |
site_id | AJ9 |
Number of Residues | 2 |
Details | binding site for residue CL Y 304 |
Chain | Residue |
Y | ILE121 |
Y | SER122 |
site_id | AK1 |
Number of Residues | 3 |
Details | binding site for residue CL Y 305 |
Chain | Residue |
J | HOH454 |
Y | LEU155 |
Y | HOH496 |
site_id | AK2 |
Number of Residues | 6 |
Details | binding site for residue 1PE Z 301 |
Chain | Residue |
R | HOH484 |
Y | PHE54 |
Z | TYR97 |
Z | SER98 |
Z | PHE101 |
Z | HOH452 |
site_id | AK3 |
Number of Residues | 4 |
Details | binding site for residue K Z 302 |
Chain | Residue |
Z | ALA183 |
Z | ASP186 |
Z | THR189 |
Z | HOH480 |
site_id | AK4 |
Number of Residues | 5 |
Details | binding site for residue CL a 301 |
Chain | Residue |
a | PHE36 |
a | ARG37 |
a | ASN38 |
a | ILE39 |
b | HOH506 |
site_id | AK5 |
Number of Residues | 4 |
Details | binding site for residue CL a 302 |
Chain | Residue |
a | ARG35 |
b | PRO115 |
b | MET116 |
b | CL302 |
site_id | AK6 |
Number of Residues | 2 |
Details | binding site for residue CL a 303 |
Chain | Residue |
a | MET43 |
a | ARG44 |
site_id | AK7 |
Number of Residues | 2 |
Details | binding site for residue 1PE a 304 |
Chain | Residue |
H | SER129 |
a | HOH472 |
site_id | AK8 |
Number of Residues | 3 |
Details | binding site for residue CL b 301 |
Chain | Residue |
b | GLY129 |
b | SER130 |
b | 6VC306 |
site_id | AK9 |
Number of Residues | 6 |
Details | binding site for residue CL b 302 |
Chain | Residue |
a | ARG35 |
a | CL302 |
b | SER46 |
b | GLY97 |
b | GLY128 |
b | GLY129 |
site_id | AL1 |
Number of Residues | 5 |
Details | binding site for residue CL b 303 |
Chain | Residue |
M | HOH440 |
b | ARG19 |
b | ARG29 |
b | GLY171 |
b | GLY172 |
site_id | AL2 |
Number of Residues | 4 |
Details | binding site for residue CL b 304 |
Chain | Residue |
b | THR31 |
b | ARG45 |
b | GLN53 |
b | HOH427 |
site_id | AL3 |
Number of Residues | 6 |
Details | binding site for residue K b 305 |
Chain | Residue |
b | MET164 |
b | ASP167 |
b | SER170 |
b | HOH441 |
b | HOH442 |
b | HOH512 |
site_id | AL4 |
Number of Residues | 15 |
Details | binding site for Ligand residues 6V1 E 148 through PRO E 149 bound to THR E 147 |
Chain | Residue |
E | MET26 |
E | VAL29 |
E | PRO127 |
E | TYR128 |
E | VAL130 |
E | GLN146 |
E | THR147 |
E | SER150 |
E | ALA151 |
E | ASN152 |
E | CL302 |
E | HOH430 |
E | HOH450 |
E | HOH465 |
E | HOH476 |
site_id | AL5 |
Number of Residues | 14 |
Details | binding site for Ligand residues 6V1 S 148 through PRO S 149 bound to THR S 147 |
Chain | Residue |
S | VAL29 |
S | PRO127 |
S | TYR128 |
S | VAL130 |
S | GLN146 |
S | THR147 |
S | SER150 |
S | ALA151 |
S | ASN152 |
S | CL301 |
S | HOH436 |
S | HOH438 |
S | HOH444 |
S | HOH494 |
site_id | AL6 |
Number of Residues | 14 |
Details | binding site for Di-peptide ASP U 46 and 6V1 U 47 |
Chain | Residue |
U | ARG43 |
U | GLY44 |
U | LYS45 |
U | ALA48 |
U | PRO149 |
U | THR194 |
U | VAL219 |
U | VAL220 |
U | THR221 |
U | VAL222 |
U | ARG228 |
U | HOH468 |
U | HOH487 |
X | HOH415 |
site_id | AL7 |
Number of Residues | 11 |
Details | binding site for Di-peptide 6V1 U 47 and ALA U 48 |
Chain | Residue |
U | VAL42 |
U | ARG43 |
U | GLY44 |
U | ASP46 |
U | VAL49 |
U | PRO149 |
U | THR194 |
U | VAL219 |
U | VAL220 |
U | ARG228 |
U | HOH487 |
site_id | AL8 |
Number of Residues | 11 |
Details | binding site for Di-peptide TYR U 160 and 6V1 U 161 |
Chain | Residue |
O | LYS49 |
O | TYR56 |
O | ASP57 |
O | SER60 |
O | VAL61 |
U | LYS116 |
U | TYR152 |
U | LYS153 |
U | TYR159 |
U | GLY162 |
U | PHE163 |
site_id | AL9 |
Number of Residues | 9 |
Details | binding site for Di-peptide 6V1 U 161 and GLY U 162 |
Chain | Residue |
O | LYS49 |
O | TYR56 |
O | ASP57 |
O | SER60 |
U | VAL151 |
U | TYR152 |
U | LYS153 |
U | TYR160 |
U | PHE163 |
site_id | AM1 |
Number of Residues | 21 |
Details | binding site for Di-peptide 6VC V 303 and THR V 1 |
Chain | Residue |
V | THR2 |
V | ILE3 |
V | ASP17 |
V | ARG19 |
V | ALA20 |
V | THR21 |
V | CYS31 |
V | LYS33 |
V | GLY47 |
V | ALA49 |
V | THR52 |
V | GLY128 |
V | SER129 |
V | GLY130 |
V | GLY168 |
V | SER169 |
V | HOH412 |
V | HOH431 |
W | ASP124 |
W | CYS128 |
W | HOH414 |
site_id | AM2 |
Number of Residues | 21 |
Details | binding site for Di-peptide 6VC V 303 and THR V 1 |
Chain | Residue |
V | THR2 |
V | ILE3 |
V | ASP17 |
V | ARG19 |
V | ALA20 |
V | THR21 |
V | CYS31 |
V | LYS33 |
V | GLY47 |
V | ALA49 |
V | THR52 |
V | GLY128 |
V | SER129 |
V | GLY130 |
V | GLY168 |
V | SER169 |
V | HOH412 |
V | HOH431 |
W | ASP124 |
W | CYS128 |
W | HOH414 |
site_id | AM3 |
Number of Residues | 16 |
Details | binding site for Di-peptide ASP X 90 and 6V1 X 91 |
Chain | Residue |
W | ARG65 |
W | 1PE303 |
X | PHE56 |
X | TYR59 |
X | ARG86 |
X | ASN87 |
X | LEU88 |
X | ALA89 |
X | LEU92 |
X | ARG93 |
X | SER94 |
X | THR96 |
X | PRO97 |
X | TYR98 |
X | HOH409 |
X | HOH437 |
site_id | AM4 |
Number of Residues | 14 |
Details | binding site for Di-peptide 6V1 X 91 and LEU X 92 |
Chain | Residue |
X | PHE56 |
X | TYR59 |
X | ASN87 |
X | LEU88 |
X | ALA89 |
X | ASP90 |
X | ARG93 |
X | SER94 |
X | THR96 |
X | PRO97 |
X | TYR98 |
X | LEU121 |
X | HOH420 |
X | HOH460 |
site_id | AM5 |
Number of Residues | 19 |
Details | binding site for Di-peptide 6VC Y 306 and THR Y 1 |
Chain | Residue |
Y | THR2 |
Y | ASP17 |
Y | ARG19 |
Y | ALA20 |
Y | THR21 |
Y | LYS33 |
Y | MET45 |
Y | GLY47 |
Y | ALA49 |
Y | GLY129 |
Y | SER130 |
Y | GLY131 |
Y | TYR169 |
Y | SER170 |
Y | CL301 |
Y | HOH449 |
Y | HOH481 |
Z | SER129 |
Z | HOH414 |
site_id | AM6 |
Number of Residues | 19 |
Details | binding site for Di-peptide 6VC Y 306 and THR Y 1 |
Chain | Residue |
Y | THR2 |
Y | ASP17 |
Y | ARG19 |
Y | ALA20 |
Y | THR21 |
Y | LYS33 |
Y | MET45 |
Y | GLY47 |
Y | ALA49 |
Y | GLY129 |
Y | SER130 |
Y | GLY131 |
Y | TYR169 |
Y | SER170 |
Y | CL301 |
Y | HOH449 |
Y | HOH481 |
Z | SER129 |
Z | HOH414 |
site_id | AM7 |
Number of Residues | 21 |
Details | binding site for Di-peptide 6VC b 306 and THR b 1 |
Chain | Residue |
V | TYR114 |
b | THR2 |
b | ASP17 |
b | ARG19 |
b | THR20 |
b | THR21 |
b | THR22 |
b | LYS33 |
b | ARG45 |
b | SER46 |
b | GLY47 |
b | ALA49 |
b | THR52 |
b | GLY129 |
b | SER130 |
b | GLY131 |
b | SER169 |
b | SER170 |
b | CL301 |
b | HOH418 |
b | HOH465 |
site_id | AM8 |
Number of Residues | 21 |
Details | binding site for Di-peptide 6VC b 306 and THR b 1 |
Chain | Residue |
V | TYR114 |
b | THR2 |
b | ASP17 |
b | ARG19 |
b | THR20 |
b | THR21 |
b | THR22 |
b | LYS33 |
b | ARG45 |
b | SER46 |
b | GLY47 |
b | ALA49 |
b | THR52 |
b | GLY129 |
b | SER130 |
b | GLY131 |
b | SER169 |
b | SER170 |
b | CL301 |
b | HOH418 |
b | HOH465 |
Functional Information from PROSITE/UniProt
site_id | PS00388 |
Number of Residues | 23 |
Details | PROTEASOME_ALPHA_1 Proteasome alpha-type subunits signature. YdraiTvFSPdGHlfQVEYAqeA |
Chain | Residue | Details |
C | TYR3-ALA25 | |
E | TYR6-ALA28 | |
A | TYR5-ALA27 | |
F | TYR7-ALA29 | |
D | TYR8-ALA30 | |
G | PHE9-ALA31 | |
B | TYR5-ALA27 |
site_id | PS00854 |
Number of Residues | 48 |
Details | PROTEASOME_BETA_1 Proteasome beta-type subunits signature. MAVqFdgGVVLGADsrtttgsyianrvtd.KltpihdrifccrsGsaAD |
Chain | Residue | Details |
b | MET4-ASP51 | |
H | ALA4-ASP51 | |
L | LEU13-ASP60 | |
K | LEU4-ASP51 | |
a | LEU12-ASP59 | |
J | ILE5-ASP52 | |
B | LEU35-ASP82 | |
I | MET11-ASP58 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 2 |
Details | ACT_SITE: Nucleophile => ECO:0000269|PubMed:25599644, ECO:0000269|PubMed:27493187 |
Chain | Residue | Details |
N | THR1 | |
b | THR1 | |
L | SER134 | |
Z | SER34 | |
Z | SER40 | |
Z | SER134 |
site_id | SWS_FT_FI2 |
Number of Residues | 2 |
Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:23186163 |
Chain | Residue | Details |
N | THR35 | |
b | THR35 | |
U | LYS102 | |
U | LYS104 | |
T | LYS205 | |
T | LYS229 |
site_id | SWS_FT_FI3 |
Number of Residues | 2 |
Details | MOD_RES: N6-acetyllysine => ECO:0007744|PubMed:19608861 |
Chain | Residue | Details |
L | LYS176 | |
Z | LYS176 | |
P | LYS127 | |
P | LYS176 | |
O | SER13 | |
O | SER15 |
site_id | SWS_FT_FI4 |
Number of Residues | 4 |
Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250 |
Chain | Residue | Details |
L | SER30 | |
L | SER181 | |
Z | SER30 | |
Z | SER181 |
site_id | SWS_FT_FI5 |
Number of Residues | 6 |
Details | CROSSLNK: Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) |
Chain | Residue | Details |
E | LYS115 | |
R | SER63 | |
E | LYS208 | |
S | LYS115 | |
S | LYS208 |
site_id | SWS_FT_FI6 |
Number of Residues | 2 |
Details | CARBOHYD: O-linked (GlcNAc) serine => ECO:0000250 |
Chain | Residue | Details |
D | SER198 | |
R | SER198 |
site_id | SWS_FT_FI7 |
Number of Residues | 2 |
Details | MOD_RES: Phosphotyrosine => ECO:0000250|UniProtKB:P17220 |
Chain | Residue | Details |
A | TYR120 | |
O | TYR120 |