8PSY
| ERK2 covelently bound to RU68 cyclohexenone based inhibitor | 分子名称: | AMP PHOSPHORAMIDATE, Mitogen-activated protein kinase 1, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{S},3~{R})-4-oxidanylidene-1-(phenylmethyl)cyclohexane-1,3-dicarboxylate | 著者 | Sok, P, Poti, A, Remenyi, A, Gogl, G. | 登録日 | 2023-07-13 | 公開日 | 2024-07-24 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold To Be Published
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6I9R
| Large subunit of the human mitochondrial ribosome in complex with Virginiamycin M and Quinupristin | 分子名称: | 16S rRNA, 39S ribosomal protein L10, mitochondrial, ... | 著者 | Modelska, A, Aibara, S, Amunts, A. | 登録日 | 2018-11-25 | 公開日 | 2020-07-08 | 最終更新日 | 2024-07-10 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Inhibition of mitochondrial translation suppresses glioblastoma stem cell growth. Cell Rep, 35, 2021
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6R7V
| Tannerella forsythia promirolysin mutant E225A | 分子名称: | CALCIUM ION, GLYCEROL, Mirolysin, ... | 著者 | Rodriguez-Banqueri, A, Guevara, T, Ksiazek, M, Potempa, J, Gomis-Ruth, F.X. | 登録日 | 2019-03-29 | 公開日 | 2019-11-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structure-based mechanism of cysteine-switch latency and of catalysis by pappalysin-family metallopeptidases. Iucrj, 7, 2020
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8AYC
| Scalindua brodae amxFabZ, I69G mutant | 分子名称: | Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase | 著者 | Dietl, A, Barends, T. | 登録日 | 2022-09-02 | 公開日 | 2023-03-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference. J.Biol.Chem., 299, 2023
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8FMK
| Crystal structure of human KRAS with extended switch I loop | 分子名称: | CHLORIDE ION, GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, ... | 著者 | Brenner, R, Landgraf, A, Gonzalez-Gutierrez, G, Bum-Erdene, K, Meroueh, S.O. | 登録日 | 2022-12-23 | 公開日 | 2023-11-22 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Crystal Packing Reveals a Potential Autoinhibited KRAS Dimer Interface and a Strategy for Small-Molecule Inhibition of RAS Signaling. Biochemistry, 62, 2023
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9B0L
| Cryo-EM structure of Acanthamoeba polyphaga mimivirus Fanzor2 ternary complex | 分子名称: | DNA (5'-D(P*AP*GP*GP*AP*GP*GP*TP*GP*GP*CP*TP*GP*CP*CP*CP*CP*GP*AP*CP*CP*GP*TP*C)-3'), DNA (5'-D(P*CP*CP*CP*A)-3'), DNA (5'-D(P*GP*AP*CP*GP*GP*TP*CP*GP*GP*GP*C)-3'), ... | 著者 | Qayyum, M.Z, Schargel, R.D, Tanwar, A.S, Kellogg, E.H, Kalathur, R.C. | 登録日 | 2024-03-12 | 公開日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (2.99 Å) | 主引用文献 | Structure of Fanzor2 reveals insights into the evolution of the TnpB superfamily. Nat.Struct.Mol.Biol., 2024
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5LZZ
| Structure of the mammalian rescue complex with Pelota and Hbs1l (combined) | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S ribosomal protein S12, ... | 著者 | Shao, S, Murray, J, Brown, A, Taunton, J, Ramakrishnan, V, Hegde, R.S. | 登録日 | 2016-10-02 | 公開日 | 2016-11-30 | 最終更新日 | 2024-10-09 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Decoding Mammalian Ribosome-mRNA States by Translational GTPase Complexes. Cell, 167, 2016
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8PJL
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8AYB
| anammox-specific FabZ from Scalindua brodae | 分子名称: | Beta-hydroxyacyl-(Acyl-carrier-protein) dehydratase | 著者 | Dietl, A, Barends, T.R.M. | 登録日 | 2022-09-02 | 公開日 | 2023-03-29 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of an unusual 3-hydroxyacyl dehydratase (FabZ) from a ladderane-producing organism with an unexpected substrate preference. J.Biol.Chem., 299, 2023
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5LD0
| Chimeric GST | 分子名称: | CHLORIDE ION, Glutathione S-transferase A1,Glutathione S-transferase alpha-2,Glutathione S-transferase A1 | 著者 | Axarli, A, Muleta, A.W, Chronopoulou, E.G, Papageorgiou, A.C, Labrou, N.E. | 登録日 | 2016-06-23 | 公開日 | 2016-09-21 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Directed evolution of glutathione transferases towards a selective glutathione-binding site and improved oxidative stability. Biochim. Biophys. Acta, 1861, 2017
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8FXP
| Structure of capsid of Agrobacterium phage Milano | 分子名称: | Linking protein 1, gp16, Linking protein 2, ... | 著者 | Sonani, R.R, Wang, F, Esteves, N.C, Kelly, R.J, Sebastian, A, Kreutzberger, M.A.B, Leiman, P.G, Scharf, B.E, Egelman, E.H. | 登録日 | 2023-01-25 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (4.04 Å) | 主引用文献 | Neck and capsid architecture of the robust Agrobacterium phage Milano. Commun Biol, 6, 2023
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8B2I
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4QGT
| The Crystal Structure of Human IgG Fc Domain with Enhanced Aromatic Sequon | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | 著者 | Kong, L, Connelly, S.C, Wilson, I.A. | 登録日 | 2014-05-25 | 公開日 | 2015-04-08 | 最終更新日 | 2024-10-09 | 実験手法 | X-RAY DIFFRACTION (2.99 Å) | 主引用文献 | Stabilizing the CH2 Domain of an Antibody by Engineering in an Enhanced Aromatic Sequon. Acs Chem.Biol., 11, 2016
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8FXR
| Structure of neck with portal vertex of capsid of Agrobacterium phage Milano | 分子名称: | Collar sheath protein, gp13, Linking protein 1, ... | 著者 | Sonani, R.R, Wang, F, Esteves, N.C, Kelly, R.J, Sebastian, A, Kreutzberger, M.A.B, Leiman, P.G, Scharf, B.E, Egelman, E.H. | 登録日 | 2023-01-25 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Neck and capsid architecture of the robust Agrobacterium phage Milano. Commun Biol, 6, 2023
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6ZWM
| cryo-EM structure of human mTOR complex 2, overall refinement | 分子名称: | ACETYL GROUP, INOSITOL HEXAKISPHOSPHATE, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, ... | 著者 | Scaiola, A, Mangia, F, Imseng, S, Boehringer, D, Ban, N, Maier, T. | 登録日 | 2020-07-28 | 公開日 | 2020-11-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | The 3.2- angstrom resolution structure of human mTORC2. Sci Adv, 6, 2020
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8PT5
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6P6W
| Cryo-EM structure of voltage-gated sodium channel NavAb N49K/L109A/M116V/G94C/Q150C disulfide crosslinked mutant in the resting state | 分子名称: | Fusion of Maltose-binding protein and voltage-gated sodium channel NavAb | 著者 | Wisedchaisri, G, Tonggu, L, McCord, E, Gamal El-Din, T.M, Wang, L, Zheng, N, Catterall, W.A. | 登録日 | 2019-06-04 | 公開日 | 2019-08-14 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (4 Å) | 主引用文献 | Resting-State Structure and Gating Mechanism of a Voltage-Gated Sodium Channel. Cell, 178, 2019
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8FWB
| Portal assembly of Agrobacterium phage Milano | 分子名称: | Portal protein, gp7 | 著者 | Sonani, R.R, Wang, F, Esteves, N.C, Kelly, R.J, Sebastian, A, Kreutzberger, M.A.B, Leiman, P.G, Scharf, B.E, Egelman, E.H. | 登録日 | 2023-01-20 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Neck and capsid architecture of the robust Agrobacterium phage Milano. Commun Biol, 6, 2023
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4QA7
| Crystal structure of H334R/Y306F HDAC8 in complex with a tetrapeptide substrate | 分子名称: | 7-AMINO-4-METHYL-CHROMEN-2-ONE, GLYCEROL, Histone deacetylase 8, ... | 著者 | Decroos, C, Bowman, C.B, Moser, J.-A.S, Christianson, K.E, Deardorff, M.A, Christianson, D.W. | 登録日 | 2014-05-02 | 公開日 | 2014-08-06 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Compromised Structure and Function of HDAC8 Mutants Identified in Cornelia de Lange Syndrome Spectrum Disorders. Acs Chem.Biol., 9, 2014
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7Y7U
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8FWC
| Collar sheath structure of Agrobacterium phage Milano | 分子名称: | Collar sheath protein, gp13 | 著者 | Sonani, R.R, Wang, F, Esteves, N.C, Kelly, R.J, Sebastian, A, Kreutzberger, M.A.B, Leiman, P.G, Scharf, B.E, Egelman, E.H. | 登録日 | 2023-01-20 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (2.96 Å) | 主引用文献 | Neck and capsid architecture of the robust Agrobacterium phage Milano. Commun Biol, 6, 2023
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8PST
| ERK2 covelently bound to RU60 cyclohexenone based inhibitor | 分子名称: | AMP PHOSPHORAMIDATE, Mitogen-activated protein kinase 1, ~{O}3-~{tert}-butyl ~{O}1-methyl (1~{R},3~{S})-1-methyl-4-oxidanylidene-cyclohexane-1,3-dicarboxylate | 著者 | Sok, P, Poti, A, Remenyi, A, Gogl, G. | 登録日 | 2023-07-13 | 公開日 | 2024-07-24 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Targeting a key protein-protein interaction surface on mitogen-activated protein kinases by a Michael acceptor-based cyclic warhead scaffold To Be Published
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8FWE
| Neck structure of Agrobacterium phage Milano, C3 symmetry | 分子名称: | Collar sheath protein, gp13, Neck 1 protein, ... | 著者 | Sonani, R.R, Wang, F, Esteves, N.C, Kelly, R.J, Sebastian, A, Kreutzberger, M.A.B, Leiman, P.G, Scharf, B.E, Egelman, E.H. | 登録日 | 2023-01-21 | 公開日 | 2023-12-06 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Neck and capsid architecture of the robust Agrobacterium phage Milano. Commun Biol, 6, 2023
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5LF3
| Human 20S proteasome complex with Bortezomib at 2.1 Angstrom | 分子名称: | CHLORIDE ION, MAGNESIUM ION, N-[(1R)-1-(DIHYDROXYBORYL)-3-METHYLBUTYL]-N-(PYRAZIN-2-YLCARBONYL)-L-PHENYLALANINAMIDE, ... | 著者 | Schrader, J, Henneberg, F, Mata, R, Tittmann, K, Schneider, T.R, Stark, H, Bourenkov, G, Chari, A. | 登録日 | 2016-06-30 | 公開日 | 2016-08-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 2016
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5LF1
| Human 20S proteasome complex with Dihydroeponemycin at 2.0 Angstrom | 分子名称: | CHLORIDE ION, MAGNESIUM ION, PENTAETHYLENE GLYCOL, ... | 著者 | Schrader, J, Henneberg, F, Mata, R, Tittmann, K, Schneider, T.R, Stark, H, Bourenkov, G, Chari, A. | 登録日 | 2016-06-30 | 公開日 | 2016-08-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design. Science, 353, 2016
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