6SX5
 
 | | Full length Mutant Open-form Sodium Channel NavMs | | 分子名称: | DODECAETHYLENE GLYCOL, HEGA-10, Ion transport protein, ... | | 著者 | Sula, A, Hollingworth, D, Wallace, B.A. | | 登録日 | 2019-09-25 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | A tamoxifen receptor within a voltage-gated sodium channel.
Mol.Cell, 81, 2021
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5LWK
 | | MaeR response regulator bound to beryllium trifluoride | | 分子名称: | BERYLLIUM TRIFLUORIDE ION, MAGNESIUM ION, Transcriptional regulatory protein | | 著者 | Miguel-Romero, L, Casino, P, Landete, J.M, Monedero, V, Zuniga, M, Marina, A. | | 登録日 | 2016-09-18 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.11 Å) | | 主引用文献 | The malate sensing two-component system MaeKR is a non-canonical class of sensory complex for C4-dicarboxylates.
Sci Rep, 7, 2017
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7RBK
 | | Human DNA polymerase beta crosslinked complex, 40 s Ca to Mg exchange | | 分子名称: | 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, 2-deoxy-3,5-di-O-phosphono-D-erythro-pentitol, DNA (5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*CP*C)-3'), ... | | 著者 | Kumar, A. | | 登録日 | 2021-07-06 | | 公開日 | 2022-03-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Interlocking activities of DNA polymerase beta in the base excision repair pathway.
Proc.Natl.Acad.Sci.USA, 119, 2022
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7AY9
 | | Crystal structure of CK2 bound by compound 7 | | 分子名称: | 1,2-ETHANEDIOL, 7-(cyclopropylamino)-5-(5-(6-oxo-1,6-dihydropyridin-3-yl)-1-(2-(piperidin-1-yl)ethyl)-1H-1,2,3-triazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carbonitrile, Casein kinase II subunit alpha, ... | | 著者 | Ferguson, A, Collie, G.W. | | 登録日 | 2020-11-11 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Metadynamics simulations of CK2 compound unbinding to understand slow dissociation kinetics.
To Be Published
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4YAK
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6SXC
 | | Crystal structure of the Voltage-Gated Sodium Channel NavMs (F208L) in complex with 4-hydroxytamoxifen (2.5 Angstrom resolution) | | 分子名称: | 4-HYDROXYTAMOXIFEN, DODECAETHYLENE GLYCOL, HEGA-10, ... | | 著者 | Sula, A, Hollingworth, D, Wallace, B.A. | | 登録日 | 2019-09-25 | | 公開日 | 2021-02-03 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | A tamoxifen receptor within a voltage-gated sodium channel.
Mol.Cell, 81, 2021
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6WK8
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6QV2
 | | Structure of ATPgS-bound outward-facing TM287/288 in complex with nanobody Nb_TM#2 | | 分子名称: | ABC transporter, ATP-binding protein, MAGNESIUM ION, ... | | 著者 | Hutter, C.A.J, Huerlimann, L.M, Zimmermann, I, Egloff, P, Seeger, M.A. | | 登録日 | 2019-03-01 | | 公開日 | 2019-05-29 | | 最終更新日 | 2019-06-05 | | 実験手法 | X-RAY DIFFRACTION (4.23 Å) | | 主引用文献 | The extracellular gate shapes the energy profile of an ABC exporter.
Nat Commun, 10, 2019
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6SG4
 | | Structure of CDK2/cyclin A M246Q, S247EN | | 分子名称: | Cyclin-A2, Cyclin-dependent kinase 2 | | 著者 | Salamina, M, Basle, A, Massa, B, Noble, M.E.M, Endicott, J.A. | | 登録日 | 2019-08-02 | | 公開日 | 2021-01-27 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Discriminative SKP2 Interactions with CDK-Cyclin Complexes Support a Cyclin A-Specific Role in p27KIP1 Degradation.
J.Mol.Biol., 433, 2021
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4YDX
 | | Crystal structure of cisplatin bound to a human copper chaperone (monomer) - new refinement | | 分子名称: | 3,3',3''-phosphanetriyltripropanoic acid, Copper transport protein ATOX1, PLATINUM (II) ION, ... | | 著者 | Shabalin, I.G, Boal, A.K, Dauter, Z, Jaskolski, M, Minor, W, Rosenzweig, A.C, Wlodawer, A. | | 登録日 | 2015-02-23 | | 公開日 | 2015-03-04 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.602 Å) | | 主引用文献 | Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
Acta Crystallogr.,Sect.D, 71, 2015
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7R5W
 | | Crystal structure of YTHDF2 with compound YLI_DF_029 | | 分子名称: | 6-cyclopropyl-1H-pyrimidine-2,4-dione, CHLORIDE ION, GLYCEROL, ... | | 著者 | Nai, F, Li, Y, Caflisch, A. | | 登録日 | 2022-02-11 | | 公開日 | 2022-03-16 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Fragment Ligands of the m 6 A-RNA Reader YTHDF2.
Acs Med.Chem.Lett., 13, 2022
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7AYW
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4YEA
 | | Crystal structure of cisplatin bound to a human copper chaperone (dimer) - new refinement | | 分子名称: | COPPER (II) ION, Copper transport protein ATOX1, SULFATE ION | | 著者 | Shabalin, I.G, Dauter, Z, Jaskolski, M, Minor, W, Wlodawer, A. | | 登録日 | 2015-02-23 | | 公開日 | 2015-03-18 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.14 Å) | | 主引用文献 | Crystallography and chemistry should always go together: a cautionary tale of protein complexes with cisplatin and carboplatin.
Acta Crystallogr.,Sect.D, 71, 2015
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8VEK
 | | IsPETase - ACC mutant | | 分子名称: | GLYCEROL, Poly(ethylene terephthalate) hydrolase, SULFATE ION | | 著者 | Joho, Y, Royan, S, Newton, S, Caputo, A.T, Ardevol Grau, A, Jackson, C. | | 登録日 | 2023-12-19 | | 公開日 | 2024-06-19 | | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | | 主引用文献 | Enhancing PET Degrading Enzymes: A Combinatory Approach.
Chembiochem, 25, 2024
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5M2Y
 | | Structure of TssK C-terminal domain from E. coli T6SS | | 分子名称: | TssK C | | 著者 | Cambillau, C, Nguyen, V.S, Spinelli, S, Desmyter, A, Legrand, P. | | 登録日 | 2016-10-13 | | 公開日 | 2017-06-28 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.61 Å) | | 主引用文献 | Type VI secretion TssK baseplate protein exhibits structural similarity with phage receptor-binding proteins and evolved to bind the membrane complex.
Nat Microbiol, 2, 2017
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8VK1
 | | X-ray crystal structure of human IgE 4C8 Fab complex with Der p 2.0103 | | 分子名称: | Der p 2 variant 3, IgE 4C8 heavy chain, IgE 4C8 light chain | | 著者 | Khatri, K, Ball, A, Smith, S.A, Champan, M.D, Pomes, A, Chruszcz, M. | | 登録日 | 2024-01-08 | | 公開日 | 2024-06-19 | | 最終更新日 | 2024-08-21 | | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | | 主引用文献 | Structural analysis of human IgE monoclonal antibody epitopes on dust mite allergen Der p 2.
J.Allergy Clin.Immunol., 154, 2024
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8QHS
 | | Cryo-EM structure of the monocin tail-tube, MttP. | | 分子名称: | Antigen A | | 著者 | Nadejda, S, Lichtenstein, R, Schlussel, S, Azulay, G, Borovok, I, Holdengraber, V, Elad, N, Wolf, S.G, Zalk, R, Zarivach, R, Frank, G.A, Herskovits, A.A. | | 登録日 | 2023-09-10 | | 公開日 | 2024-06-19 | | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | | 主引用文献 | Tailocin cell factories
To Be Published
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8DO5
 | | Crystal structure of NahE in complex with intermediate (R)-4-hydroxy-4-(2-hydroxyphenyl)-2-iminobutanoate | | 分子名称: | (4R)-4-hydroxy-4-(2-hydroxyphenyl)butanoic acid, DIMETHYL SULFOXIDE, Trans-ohydrobenzylidenepyruvate hydratase aldolase | | 著者 | LeVieux, J.A, Hardtke, H.A, Zhang, Y.J. | | 登録日 | 2022-07-12 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A mutagenic analysis of NahE, a hydratase-aldolase in the naphthalene degradative pathway.
Arch.Biochem.Biophys., 733, 2023
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7B4W
 | | Broadly neutralizing DARPin bnD.3 in complex with the HIV-1 envelope variable loop 3 crown mimetic peptide V3-IF (BG505) | | 分子名称: | 1,2-ETHANEDIOL, ACETATE ION, Broadly neutralizing DARPin bnD.3, ... | | 著者 | Friedrich, N, Stiegeler, E, Glogl, M, Lemmin, T, Hansen, S, Kadelka, C, Wu, Y, Ernst, P, Maliqi, L, Foulkes, C, Morin, M, Eroglu, M, Liechti, T, Ivan, B, Reinberg, T, Schaefer, J, Karakus, U, Ursprung, S, Mann, A, Rusert, P, Kouyos, R.D, Robinson, J.A, Gunthard, H.F, Pluckthun, A, Trkola, A. | | 登録日 | 2020-12-02 | | 公開日 | 2021-11-24 | | 最終更新日 | 2024-05-01 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Distinct conformations of the HIV-1 V3 loop crown are targetable for broad neutralization.
Nat Commun, 12, 2021
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5LYN
 | | Structure of the Tpr Domain of Sgt2 in complex with yeast Ssa1 peptide fragment | | 分子名称: | PRO-THR-VAL-GLU-GLU-VAL-ASP, Small glutamine-rich tetratricopeptide repeat-containing protein 2, ZINC ION | | 著者 | Krysztofinska, E.M, Evans, N.J, Thapaliya, A, Murray, J.W, Morgan, R.M.L, Martinez-Lumbreras, S, Isaacson, R.L. | | 登録日 | 2016-09-28 | | 公開日 | 2017-10-25 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structure and Interactions of the TPR Domain of Sgt2 with Yeast Chaperones and Ybr137wp.
Front Mol Biosci, 4, 2017
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6ZRF
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6ZRQ
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8EDP
 | | Crystal structure of a three-tetrad, parallel, and K+ stabilized homopurine G-quadruplex from human chromosome 7 | | 分子名称: | COBALT HEXAMMINE(III), DNA (5'-D(*AP*GP*GP*GP*AP*AP*AP*AP*GP*GP*GP*GP*AP*GP*GP*GP*AP*AP*AP*AP*GP*GP*GP*G)-3'), N-METHYLMESOPORPHYRIN, ... | | 著者 | Ye, M, Yatsunyk, L.A. | | 登録日 | 2022-09-05 | | 公開日 | 2022-12-28 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | Homopurine guanine-rich sequences in complex with N-methyl mesoporphyrin IX form parallel G-quadruplex dimers and display a unique symmetry tetrad.
Bioorg.Med.Chem., 77, 2022
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4YI3
 | | Crystal structure of Gpb in complex with 4a | | 分子名称: | DIMETHYL SULFOXIDE, Glycogen phosphorylase, muscle form, ... | | 著者 | Kantsadi, A.L, Chatzileontiadou, D.S.M, Stravodimos, G.A, Leonidas, D.D. | | 登録日 | 2015-02-27 | | 公開日 | 2015-11-18 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Glycogen phosphorylase as a target for type 2 diabetes: synthetic, biochemical, structural and computational evaluation of novel N-acyl-N -( beta-D-glucopyranosyl) urea inhibitors.
Curr Top Med Chem, 15, 2015
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6QQM
 | | Crystal structure of the alpha carbonic anhydrase from Schistosoma mansoni | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Putative carbonic anhydrase, ... | | 著者 | Ferraroni, M, Angeli, A, Supuran, C.T. | | 登録日 | 2019-02-18 | | 公開日 | 2019-11-06 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Structural Insights into Schistosoma mansoni Carbonic Anhydrase (SmCA) Inhibition by Selenoureido-Substituted Benzenesulfonamides.
J.Med.Chem., 64, 2021
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