6CLW
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![BU of 6clw by Molmil](/molmil-images/mine/6clw) | Crystal structure of TnmH | 分子名称: | O-methyltransferase | 著者 | Chang, C.Y, Annaval, T, Adhikari, A, Yan, X, Shen, B. | 登録日 | 2018-03-02 | 公開日 | 2019-03-06 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.74 Å) | 主引用文献 | Characterization of TnmH as anO-Methyltransferase Revealing Insights into Tiancimycin Biosynthesis and Enabling a Biocatalytic Strategy To Prepare Antibody-Tiancimycin Conjugates. J.Med.Chem., 63, 2020
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6VKN
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![BU of 6vkn by Molmil](/molmil-images/mine/6vkn) | BG505 SOSIP.v5.2.N241.N289 in complex with rhesus macaque Fab RM19R | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Cottrell, C.A, Ward, A.B. | 登録日 | 2020-01-21 | 公開日 | 2020-08-12 | 最終更新日 | 2020-09-02 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Targeting HIV Env immunogens to B cell follicles in nonhuman primates through immune complex or protein nanoparticle formulations. NPJ Vaccines, 5, 2020
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7AT5
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![BU of 7at5 by Molmil](/molmil-images/mine/7at5) | Structure of protein kinase ck2 catalytic subunit (csnk2a1 gene product) in complex with the bivalent inhibitor KN2 | 分子名称: | 1,2-ETHANEDIOL, 2-(3,4-dichlorophenyl)ethanamine, Casein kinase II subunit alpha, ... | 著者 | Lindenblatt, D, Applegate, V, Nickelsen, A, Klussmann, M, Neundorf, I, Goetz, C, Jose, J, Niefind, K. | 登録日 | 2020-10-29 | 公開日 | 2021-08-04 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.77 Å) | 主引用文献 | Molecular Plasticity of Crystalline CK2 alpha ' Leads to KN2, a Bivalent Inhibitor of Protein Kinase CK2 with Extraordinary Selectivity. J.Med.Chem., 65, 2022
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4V8H
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![BU of 4v8h by Molmil](/molmil-images/mine/4v8h) | Crystal structure of HPF bound to the 70S ribosome. | 分子名称: | 16S Ribosomal RNA, 23S Ribosomal RNA, 30S Ribosomal Protein S10, ... | 著者 | Polikanov, Y.S, Blaha, G.M, Steitz, T.A. | 登録日 | 2011-12-11 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis. Science, 336, 2012
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2W4H
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![BU of 2w4h by Molmil](/molmil-images/mine/2w4h) | Isometrically contracting insect asynchronous flight muscle quick frozen after a quick release step | 分子名称: | MYOSIN HEAVY CHAIN, SKELETAL MUSCLE, ADULT, ... | 著者 | Wu, S, Liu, J, Reedy, M.C, Tregear, R.T, Winkler, H, Franzini-Armstrong, C, Sasaki, H, Lucaveche, C, Goldman, Y.E, Reedy, M.K, Taylor, K.A. | 登録日 | 2008-11-25 | 公開日 | 2010-08-25 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (35 Å) | 主引用文献 | Structural Changes in Isometrically Contracting Insect Flight Muscle Trapped Following a Mechanical Perturbation. Plos One, 7, 2012
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4IKP
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![BU of 4ikp by Molmil](/molmil-images/mine/4ikp) | Crystal structure of coactivator-associated arginine methyltransferase 1 with methylenesinefungin | 分子名称: | (2S,5S)-2,6-diamino-5-{[(2R,3S,4R,5R)-5-(6-amino-9H-purin-9-yl)-3,4-dihydroxytetrahydrofuran-2-yl]methyl}hexanoic acid, GLYCEROL, Histone-arginine methyltransferase CARM1, ... | 著者 | Dong, A, Dombrovski, L, He, H, Ibanez, G, Wernimont, A, Zheng, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Min, J, Luo, M, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2012-12-27 | 公開日 | 2013-02-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A chemical probe of CARM1 alters epigenetic plasticity against breast cancer cell invasion. Elife, 8, 2019
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5D6S
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![BU of 5d6s by Molmil](/molmil-images/mine/5d6s) | Structure of epoxyqueuosine reductase from Streptococcus thermophilus. | 分子名称: | COBALAMIN, Epoxyqueuosine reductase, IRON/SULFUR CLUSTER | 著者 | Payne, K.A.P, Fisher, K, Dunstan, M.S, Sjuts, H, Leys, D. | 登録日 | 2015-08-12 | 公開日 | 2015-09-23 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | Epoxyqueuosine Reductase Structure Suggests a Mechanism for Cobalamin-dependent tRNA Modification. J.Biol.Chem., 290, 2015
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7AK9
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![BU of 7ak9 by Molmil](/molmil-images/mine/7ak9) | Structure of Salmonella TacT3 toxin bound to TacA3 antitoxin C-terminal peptide | 分子名称: | ABC transporter, Acetyltransferase, DEPHOSPHO COENZYME A | 著者 | Grabe, G.J, Morgan, R.M.L, Hare, S.A, Helaine, S. | 登録日 | 2020-09-30 | 公開日 | 2021-08-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing. Nat.Chem.Biol., 17, 2021
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3ZDI
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![BU of 3zdi by Molmil](/molmil-images/mine/3zdi) | Glycogen Synthase Kinase 3 Beta complexed with Axin Peptide and Inhibitor 7d | 分子名称: | 3,6-Diamino-4-(2-chlorophenyl)thieno[2,3-b]pyridine-2,5-dicarbonitrile, AXIN-1, GLYCOGEN SYNTHASE KINASE-3 BETA, ... | 著者 | Oberholzer, A.E, Pearl, L.H. | 登録日 | 2012-11-27 | 公開日 | 2012-12-26 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.645 Å) | 主引用文献 | 3,6-Diamino-4-(2-Halophenyl)-2-Benzoylthieno(2,3-B) Pyridine-5-Carbonitriles are Selective Inhibitors of Plasmodium Falciparum Glycogen Synthase Kinase-3 (Pfgsk-3) J.Med.Chem., 56, 2013
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6VS6
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6VV6
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![BU of 6vv6 by Molmil](/molmil-images/mine/6vv6) | Mycobacterium tuberculosis dihydrofolate reductase in complex with JEB113 | 分子名称: | 1-(4-fluorophenyl)-5-[3-(1H-indol-3-yl)propoxy]-1H-pyrazole-4-carboxylic acid, COBALT (II) ION, Dihydrofolate reductase, ... | 著者 | Ribeiro, J.A, Dias, M.V.B, Chaves-Pacheco, S.M. | 登録日 | 2020-02-17 | 公開日 | 2020-07-15 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.235 Å) | 主引用文献 | Using a Fragment-Based Approach to Identify Alternative Chemical Scaffolds Targeting Dihydrofolate Reductase fromMycobacterium tuberculosis. Acs Infect Dis., 6, 2020
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5V54
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![BU of 5v54 by Molmil](/molmil-images/mine/5v54) | Crystal structure of 5-HT1B receptor in complex with methiothepin | 分子名称: | 1-methyl-4-[(5~{S})-3-methylsulfanyl-5,6-dihydrobenzo[b][1]benzothiepin-5-yl]piperazine, 5-hydroxytryptamine receptor 1B,OB-1 fused 5-HT1b receptor,5-hydroxytryptamine receptor 1B | 著者 | Yin, W.C, Zhou, X.E, Yang, D, de Waal, P, Wang, M.T, Dai, A, Cai, X, Huang, C.Y, Liu, P, Yin, Y, Liu, B, Caffrey, M, Melcher, K, Xu, Y, Wang, M.W, Xu, H.E, Jiang, Y. | 登録日 | 2017-03-13 | 公開日 | 2018-02-07 | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | 主引用文献 | A common antagonistic mechanism for class A GPCRs revealed by the structure of the human 5-HT1B serotonin receptor bound to an antagonist Cell Discov, 2018
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7AYV
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![BU of 7ayv by Molmil](/molmil-images/mine/7ayv) | X-ray crystallographic structure of (6-4)photolyase from Drosophila melanogaster at cryogenic temperature | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, RE11660p, ... | 著者 | Cellini, A, Wahlgren, W.Y, Henry, L, Westenhoff, S. | 登録日 | 2020-11-13 | 公開日 | 2021-08-18 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | The three-dimensional structure of Drosophila melanogaster (6-4) photolyase at room temperature. Acta Crystallogr D Struct Biol, 77, 2021
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6VW0
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![BU of 6vw0 by Molmil](/molmil-images/mine/6vw0) | Mycobacterium tuberculosis RNAP S456L mutant open promoter complex | 分子名称: | DNA (65-MER), DNA-directed RNA polymerase subunit alpha, DNA-directed RNA polymerase subunit beta, ... | 著者 | Lilic, M, Boyaci, H, Chen, J, Darst, S.A, Campbell, E.A. | 登録日 | 2020-02-18 | 公開日 | 2020-10-21 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.59 Å) | 主引用文献 | The antibiotic sorangicin A inhibits promoter DNA unwinding in a Mycobacterium tuberculosis rifampicin-resistant RNA polymerase. Proc.Natl.Acad.Sci.USA, 117, 2020
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4IB6
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![BU of 4ib6 by Molmil](/molmil-images/mine/4ib6) | Bovine beta-lactoglobulin (isoform A) in complex with lauric acid (C12) | 分子名称: | Beta-lactoglobulin, LAURIC ACID | 著者 | Loch, J.I, Bonarek, P, Polit, A, Swiatek, S, Dziedzicka-Wasylewska, M, Lewinski, K. | 登録日 | 2012-12-08 | 公開日 | 2013-06-26 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The differences in binding 12-carbon aliphatic ligands by bovine beta-lactoglobulin isoform A and B studied by isothermal titration calorimetry and X-ray crystallography J.Mol.Recognit., 26, 2013
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4UZI
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![BU of 4uzi by Molmil](/molmil-images/mine/4uzi) | Crystal Structure of AauDyP Complexed with Imidazole | 分子名称: | (4R)-2-METHYLPENTANE-2,4-DIOL, (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Strittmatter, E, Liers, C, Ullrich, R, Hofrichter, M, Piontek, K, Plattner, D.A. | 登録日 | 2014-09-05 | 公開日 | 2015-01-14 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | The Toolbox of Auricularia Auricula-Judae Dye-Decolorizing Peroxidase - Identification of Three New Potential Substrate-Interaction Sites. Arch.Biochem.Biophys., 574, 2015
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4IDQ
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![BU of 4idq by Molmil](/molmil-images/mine/4idq) | human atlastin-1 1-446, N440T, GDPAlF4- | 分子名称: | Atlastin-1, GUANOSINE-5'-DIPHOSPHATE, HEXAETHYLENE GLYCOL, ... | 著者 | Byrnes, L.J, Singh, A, Szeto, K, Benvin, N.M, O'Donnell, J.P, Zipfel, W.R, Sondermann, H. | 登録日 | 2012-12-12 | 公開日 | 2013-01-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | 主引用文献 | Structural basis for conformational switching and GTP loading of the large G protein atlastin. Embo J., 32, 2013
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4IBJ
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![BU of 4ibj by Molmil](/molmil-images/mine/4ibj) | Ebola virus VP35 bound to small molecule | 分子名称: | 3-{(5S)-3-hydroxy-2-oxo-4-[3-(trifluoromethyl)benzoyl]-5-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, Polymerase cofactor VP35 | 著者 | Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K. | 登録日 | 2012-12-08 | 公開日 | 2014-03-19 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014
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2W3I
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![BU of 2w3i by Molmil](/molmil-images/mine/2w3i) | Crystal Structure of FXa in complex with 4,4-disubstituted pyrrolidine-1,2-dicarboxamide inhibitor 2 | 分子名称: | (2R,4S)-N^1^-(4-chlorophenyl)-4-(2,4-difluorophenyl)-4-hydroxy-N^2^-(2-oxo-2H-1,3'-bipyridin-6'-yl)pyrrolidine-1,2-dicarboxamide, CALCIUM ION, COAGULATION FACTOR X, ... | 著者 | Zhang, E, Mochalkin, I, Casimiro-Garcia, A, Van Huis, C.A. | 登録日 | 2008-11-12 | 公開日 | 2009-04-07 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Exploration of 4,4-Disubstituted Pyrrolidine-1,2-Dicarboxamides as Potent, Orally Active Factor Xa Inhibitors with Extended Duration of Action. Bioorg.Med.Chem., 17, 2009
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4IC1
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![BU of 4ic1 by Molmil](/molmil-images/mine/4ic1) | Crystal structure of SSO0001 | 分子名称: | IRON/SULFUR CLUSTER, MANGANESE (II) ION, Uncharacterized protein | 著者 | Nocek, B, Skarina, T, Lemak, S, Beloglazova, N, Flick, R, Brown, G, Savchenko, A, Joachimiak, A, Yakunin, A.F, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2012-12-09 | 公開日 | 2013-01-16 | 最終更新日 | 2014-07-02 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Toroidal structure and DNA cleavage by the CRISPR-associated [4Fe-4S] cluster containing Cas4 nuclease SSO0001 from Sulfolobus solfataricus. J.Am.Chem.Soc., 135, 2013
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4IFA
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![BU of 4ifa by Molmil](/molmil-images/mine/4ifa) | 1.5 Angstrom resolution crystal structure of an extracellular protein containing a SCP domain from Bacillus anthracis str. Ames | 分子名称: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | 著者 | Halavaty, A.S, Minasov, G, Dubrovska, I, Winsor, J, Shuvalova, L, Shatsman, S, Peterson, S.N, Anderson, W.F, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2012-12-14 | 公開日 | 2012-12-26 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | 1.5 Angstrom resolution crystal structure of an extracellular protein containing a SCP domain from Bacillus anthracis str. Ames To be Published
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7B5T
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4V4O
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![BU of 4v4o by Molmil](/molmil-images/mine/4v4o) | Crystal Structure of the Chaperonin Complex Cpn60/Cpn10/(ADP)7 from Thermus Thermophilus | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, DIMETHYL SULFOXIDE, MAGNESIUM ION, ... | 著者 | Shimamura, T, Koike-Takeshita, A, Yokoyama, K, Masui, R, Murai, N, Yoshida, M, Taguchi, H, Iwata, S. | 登録日 | 2004-05-23 | 公開日 | 2014-07-09 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of the native chaperonin complex from Thermus thermophilus revealed unexpected asymmetry at the cis-cavity STRUCTURE, 12, 2004
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1JTY
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![BU of 1jty by Molmil](/molmil-images/mine/1jty) | Crystal structure of the multidrug binding transcriptional regulator QacR bound to ethidium | 分子名称: | ETHIDIUM, HYPOTHETICAL TRANSCRIPTIONAL REGULATOR IN QACA 5'REGION, SULFATE ION | 著者 | Schumacher, M.A, Miller, M.C, Grkovic, S, Brown, M.H, Skurray, R.A, Brennan, R.G. | 登録日 | 2001-08-22 | 公開日 | 2001-12-12 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.97 Å) | 主引用文献 | Structural mechanisms of QacR induction and multidrug recognition. Science, 294, 2001
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3X41
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![BU of 3x41 by Molmil](/molmil-images/mine/3x41) | Copper amine oxidase from Arthrobacter globiformis: Product Schiff-base form produced by anaerobic reduction in the presence of sodium bromide | 分子名称: | BROMIDE ION, COPPER (II) ION, GLYCEROL, ... | 著者 | Okajima, T, Nakanishi, S, Murakawa, T, Kataoka, M, Hayashi, H, Hamaguchi, A, Nakai, T, Kawano, Y, Yamaguchi, H, Tanizawa, K. | 登録日 | 2015-03-10 | 公開日 | 2015-08-19 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | 主引用文献 | Probing the Catalytic Mechanism of Copper Amine Oxidase from Arthrobacter globiformis with Halide Ions. J.Biol.Chem., 290, 2015
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