Crystal structure of HPF bound to the 70S ribosome.

This is a large structure.

Summary for 4V8H

Integrates3V26 3V27 3V28 3V29
Descriptor16S Ribosomal RNA, 30S Ribosomal Protein S2, 30S Ribosomal Protein S3, ... (56 entities in total)
Functional Keywordsribosome hibernation factor, yhbh, protein e, stress response, stationary phase, ribosome hibernation, ribosome
Biological sourceEscherichia coli
Total number of polymer chains106
Total molecular weight4400353.83
Polikanov, Y.S.,Blaha, G.M.,Steitz, T.A. (deposition date: 2011-12-11, release date: 2014-07-09, Last modification date: 2014-12-10)
Primary citation
Polikanov, Y.S.,Blaha, G.M.,Steitz, T.A.
How Hibernation Factors RMF, HPF, and YfiA Turn Off Protein Synthesis.
Science, 336:915-918, 2012
PubMed: 22605777 (PDB entries with the same primary citation)
DOI: 10.1126/science.1218538
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.257180.6%17.4%4.6%0.46MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4v8h
no rotation
Molmil generated image of 4v8h
rotated about x axis by 90°
Molmil generated image of 4v8h
rotated about y axis by 90°
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