6XB7
| IRES-targeting Small Molecule Inhibits Enterovirus 71 Replication via Allosteric Stabilization of a Ternary Complex | 分子名称: | 3-amino-N-(diaminomethylidene)-5-(dimethylamino)-6-(phenylethynyl)pyrazine-2-carboxamide, RNA (41-MER) | 著者 | Tolbert, B.S, Davila, J, Sugarman, A.L, Chiu, L.Y. | 登録日 | 2020-06-05 | 公開日 | 2020-09-02 | 最終更新日 | 2024-05-01 | 実験手法 | SOLUTION NMR | 主引用文献 | IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun, 11, 2020
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6WT7
| Structure of a metazoan TIR-STING receptor from C. gigas in complex with 2',3'-cGAMP | 分子名称: | Metazoan TIR-STING fusion, cGAMP | 著者 | Morehouse, B.R, Govande, A.A, Millman, A, Keszei, A.F.A, Lowey, B, Ofir, G, Shao, S, Sorek, R, Kranzusch, P.J. | 登録日 | 2020-05-01 | 公開日 | 2020-09-09 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | STING cyclic dinucleotide sensing originated in bacteria. Nature, 586, 2020
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6WRH
| The crystal structure of Papain-Like Protease of SARS CoV-2 , C111S mutant | 分子名称: | CHLORIDE ION, GLYCEROL, Non-structural protein 3, ... | 著者 | Osipiuk, J, Tesar, C, Jedrzejczak, R, Endres, M, Welk, L, Babnigg, G, Kim, Y, Michalska, K, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2020-04-29 | 公開日 | 2020-05-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of papain-like protease from SARS-CoV-2 and its complexes with non-covalent inhibitors. Nat Commun, 12, 2021
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7BEU
| Human glutathione transferase M1-1 | 分子名称: | Glutathione S-transferase Mu 1, SODIUM ION | 著者 | Papageorgiou, A.C, Poudel, N. | 登録日 | 2020-12-28 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.59 Å) | 主引用文献 | Ligandability Assessment of Human Glutathione Transferase M1-1 Using Pesticides as Chemical Probes. Int J Mol Sci, 23, 2022
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7BB0
| Crystal structure of the cAMP-dependent protein kinase A cocrystallized with NAT22-366511 and PKI (5-24) | 分子名称: | (R)-3,3-dimethyl-5-oxo-5-(6-(3-(pyridin-4-yl)-1,2,4-oxadiazol-5-yl)-1,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl)pentanoic acid, cAMP-dependent protein kinase catalytic subunit alpha, cAMP-dependent protein kinase inhibitor alpha | 著者 | Oebbeke, M, Mueller, J, Glinca, S, Heine, A, Klebe, G. | 登録日 | 2020-12-16 | 公開日 | 2022-01-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Crystal structure of the cAMP-dependent protein kinase A cocrystallized with NAT22-366511 and PKI (5-24) To Be Published
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6WYD
| CRYSTAL STRUCTURE OF MYELOPEROXIDASE SUBFORM C (MPO) COMPLEX WITH Compound-12 (AKA; 7-benzyl-1H-[1,2,3]triazolo[4,5-b]pyrid | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 7-benzyl-1H-[1,2,3]triazolo[4,5-b]pyridin-5-amine, CALCIUM ION, ... | 著者 | Khan, J.A. | 登録日 | 2020-05-12 | 公開日 | 2020-10-14 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | Discovery and structure activity relationships of 7-benzyl triazolopyridines as stable, selective, and reversible inhibitors of myeloperoxidase. Bioorg.Med.Chem., 28, 2020
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7BC1
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8FAJ
| OXA-48-NA-1-157 inhibitor complex | 分子名称: | (5R)-3-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-5-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-5-methyl-4,5-dihydro-1H-pyrrole-2-carboxylic acid, Beta-lactamase, CADMIUM ION, ... | 著者 | Smith, C.A, Stewart, N.K, Toth, M, Vakulenko, S.B. | 登録日 | 2022-11-28 | 公開日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The C5 alpha-Methyl-Substituted Carbapenem NA-1-157 Exhibits Potent Activity against Klebsiella spp. Isolates Producing OXA-48-Type Carbapenemases. Acs Infect Dis., 9, 2023
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6X1Y
| Mre11 dimer in complex with small molecule modulator PFMI | 分子名称: | (5Z)-5-[(3-methoxyphenyl)methylidene]-2-sulfanylidene-1,3-thiazolidin-4-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Nuclease SbcCD subunit D | 著者 | Arvai, A.S, Moiani, D, Tainer, J.A. | 登録日 | 2020-05-19 | 公開日 | 2020-06-10 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | 主引用文献 | Fragment- and structure-based drug discovery for developing therapeutic agents targeting the DNA Damage Response. Prog.Biophys.Mol.Biol., 163, 2021
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6WEF
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6WJ5
| Structure of human TRPA1 in complex with inhibitor GDC-0334 | 分子名称: | (4R,5S)-4-fluoro-1-[(4-fluorophenyl)sulfonyl]-5-methyl-N-({5-(trifluoromethyl)-2-[2-(trifluoromethyl)pyrimidin-5-yl]pyridin-4-yl}methyl)-L-prolinamide, Transient receptor potential cation channel subfamily A member 1 | 著者 | Rohou, A, Rouge, L, Arthur, C.P, Volgraf, M, Chen, H. | 登録日 | 2020-04-11 | 公開日 | 2021-02-17 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | A TRPA1 inhibitor suppresses neurogenic inflammation and airway contraction for asthma treatment. J.Exp.Med., 218, 2021
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6WSM
| Crystal structure of coiled coil region of human septin 8 | 分子名称: | SULFATE ION, Septin-8 | 著者 | Cabrejos, D.A.L, Cavini, I, Sala, F.A, Valadares, N.F, Pereira, H.M, Brandao-Neto, J, Nascimento, A.F.Z, Uson, I, Araujo, A.P.U, Garratt, R.C. | 登録日 | 2020-05-01 | 公開日 | 2021-03-17 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.451 Å) | 主引用文献 | Orientational Ambiguity in Septin Coiled Coils and its Structural Basis. J.Mol.Biol., 433, 2021
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6WQU
| CSL (RBPJ) bound to Notch3 RAM and DNA | 分子名称: | DNA (5'-D(*AP*AP*TP*CP*TP*TP*TP*CP*CP*CP*AP*CP*GP*GP*T)-3'), DNA (5'-D(*TP*TP*AP*CP*CP*GP*TP*GP*GP*GP*AP*AP*AP*GP*A)-3'), Neurogenic locus notch homolog protein 3, ... | 著者 | Kovall, R.A, Gagliani, E, Hall, D. | 登録日 | 2020-04-29 | 公開日 | 2021-03-31 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.41 Å) | 主引用文献 | PIM-induced phosphorylation of Notch3 promotes breast cancer tumorigenicity in a CSL-independent fashion. J.Biol.Chem., 296, 2021
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6WNM
| The structure of Pf4r from a superinfective isolate of the filamentous phage Pf4 of Pseudomonas aeruginosa PA01 | 分子名称: | Pf4r, [(2R)-3-{[2-(carboxymethoxy)benzene-1-carbonyl]amino}-2-methoxypropyl](hydroxy)mercury | 著者 | Michie, K.A, Norrian, P, Duggin, I.G, McDougald, D, Rice, S.A. | 登録日 | 2020-04-22 | 公開日 | 2021-04-07 | 最終更新日 | 2024-05-22 | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | 主引用文献 | The Repressor C Protein, Pf4r, Controls Superinfection of Pseudomonas aeruginosa PAO1 by the Pf4 Filamentous Phage and Regulates Host Gene Expression. Viruses, 13, 2021
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6WHN
| Histone deacetylases complex with peptide macrocycles | 分子名称: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, DI(HYDROXYETHYL)ETHER, Histone deacetylase 2, ... | 著者 | Bera, A.K, Hosseinzadeh, P, Watson, P, Baker, D. | 登録日 | 2020-04-08 | 公開日 | 2021-04-21 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Anchor extension: a structure-guided approach to design cyclic peptides targeting enzyme active sites. Nat Commun, 12, 2021
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5NDW
| Crystal structure of aminoglycoside TC007 bound to the yeast 80S ribosome | 分子名称: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | 著者 | Prokhorova, I, Djumagulov, M, Urzhumtsev, A, Yusupov, M, Yusupova, G. | 登録日 | 2017-03-09 | 公開日 | 2017-12-13 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | 主引用文献 | Aminoglycoside interactions and impacts on the eukaryotic ribosome. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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6Y1N
| Crystal structure of the phosphonate-modified A.5 antibody FAB fragment | 分子名称: | 8-METHYL-8-AZABICYCLO[3.2.1]OCTAN-3-YL PHENYLPHOSPHONATE, FAB A.5 Heavy chain, FAB A.5 Light Chain | 著者 | Chatziefthimiou, S, Mokrushina, Y, Smirnov, I, Gabibov, A, Wilmanns, M. | 登録日 | 2020-02-12 | 公開日 | 2020-09-23 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers. Proc.Natl.Acad.Sci.USA, 117, 2020
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4UE4
| Structural basis for targeting and elongation arrest of Bacillus signal recognition particle | 分子名称: | 6S RNA, FTSQ SIGNAL SEQUENCE, SIGNAL RECOGNITION PARTICLE PROTEIN | 著者 | Beckert, B, Kedrov, A, Sohmen, D, Kempf, G, Wild, K, Sinning, I, Stahlberg, H, Wilson, D.N, Beckmann, R. | 登録日 | 2014-12-15 | 公開日 | 2015-09-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (7 Å) | 主引用文献 | Translational Arrest by a Prokaryotic Signal Recognition Particle is Mediated by RNA Interactions. Nat.Struct.Mol.Biol., 22, 2015
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6WPN
| Crystal structure of a putative oligosaccharide periplasmic-binding protein from Synechococcus sp. MITs9220 | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Substrate-binding protein | 著者 | Ford, B.A, Michie, K.A, Paulsen, I.T, Mabbutt, B.C, Shah, B.S. | 登録日 | 2020-04-27 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | 主引用文献 | Novel functional insights into a modified sugar-binding protein from Synechococcus MITS9220. Sci Rep, 12, 2022
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6QYB
| Streptomyces lividans Ccsp mutant - H111A | 分子名称: | COPPER (I) ION, cytosolic copper storage protein | 著者 | Straw, M.L, Hough, M.A. | 登録日 | 2019-03-08 | 公開日 | 2019-07-10 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.18 Å) | 主引用文献 | A Histidine Residue and a Tetranuclear Cuprous-thiolate Cluster Dominate the Copper Loading Landscape of a Copper Storage Protein from Streptomyces lividans. Chemistry, 25, 2019
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6WPX
| Crystal structure of Bacillus licheniformis lipase BlEst2 in propetide form | 分子名称: | BlEst2, IODIDE ION | 著者 | Nakamura, A.M, Godoy, A.S, Kadowaki, M.A.S, Polikarpov, I. | 登録日 | 2020-04-28 | 公開日 | 2021-06-09 | 最終更新日 | 2024-08-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structures of BlEst2 from Bacillus licheniformis in its propeptide and mature forms reveal autoinhibitory effects of the C-terminal domain Febs J., n/a, 2024
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9ABP
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9AX6
| Tricomplex of RMC-6236, KRAS G12D, and CypA | 分子名称: | (1R,2S)-N-[(1P,7S,9S,13R,20M)-21-ethyl-20-{2-[(1R)-1-methoxyethyl]-5-(4-methylpiperazin-1-yl)pyridin-3-yl}-17,17-dimethyl-8,14-dioxo-15-oxa-4-thia-9,21,27,28-tetraazapentacyclo[17.5.2.1~2,5~.1~9,13~.0~22,26~]octacosa-1(24),2,5(28),19,22,25-hexaen-7-yl]-2-methylcyclopropane-1-carboxamide, GTPase KRas, MAGNESIUM ION, ... | 著者 | Tomlinson, A.C.A, Saldajeno-Concar, M, Knox, J.E, Yano, J.K. | 登録日 | 2024-03-05 | 公開日 | 2024-04-17 | 最終更新日 | 2024-06-12 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Translational and Therapeutic Evaluation of RAS-GTP Inhibition by RMC-6236 in RAS-Driven Cancers. Cancer Discov, 14, 2024
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4UE5
| Structural basis for targeting and elongation arrest of Bacillus signal recognition particle | 分子名称: | 7S RNA, SIGNAL RECOGNITION PARTICLE 54 KDA PROTEIN, SIGNAL RECOGNITION PARTICLE 9 KDA PROTEIN, ... | 著者 | Beckert, B, Kedrov, A, Sohmen, D, Kempf, G, Wild, K, Sinning, I, Stahlberg, H, Wilson, D.N, Beckmann, R. | 登録日 | 2014-12-15 | 公開日 | 2015-09-09 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (9 Å) | 主引用文献 | Translational Arrest by a Prokaryotic Signal Recognition Particle is Mediated by RNA Interactions. Nat.Struct.Mol.Biol., 22, 2015
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5OB3
| iSpinach aptamer | 分子名称: | 4-(3,5-difluoro-4-hydroxybenzyl)-1,2-dimethyl-1H-imidazol-5-ol, POTASSIUM ION, RNA aptamer (69-MER), ... | 著者 | Fernandez-Millan, P, Autour, A, Westhof, E, Ryckelynck, M. | 登録日 | 2017-06-26 | 公開日 | 2017-10-04 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.004 Å) | 主引用文献 | Crystal structure and fluorescence properties of the iSpinach aptamer in complex with DFHBI. RNA, 23, 2017
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