6XB7

IRES-targeting Small Molecule Inhibits Enterovirus 71 Replication via Allosteric Stabilization of a Ternary Complex

Summary for 6XB7

Entry DOI	10.2210/pdb6xb7/pdb
NMR Information	BMRB: 50268
Descriptor	RNA (41-MER), 3-amino-N-(diaminomethylidene)-5-(dimethylamino)-6-(phenylethynyl)pyrazine-2-carboxamide (2 entities in total)
Functional Keywords	rna-small molecule complex, rna binding protein, rna
Biological source	Enterovirus A71
Total number of polymer chains	1
Total formula weight	13464.21
Authors	Tolbert, B.S.,Davila, J.,Sugarman, A.L.,Chiu, L.Y. (deposition date: 2020-06-05, release date: 2020-09-02, Last modification date: 2020-10-07)
Primary citation	Davila-Calderon, J.,Patwardhan, N.N.,Chiu, L.Y.,Sugarman, A.,Cai, Z.,Penutmutchu, S.R.,Li, M.L.,Brewer, G.,Hargrove, A.E.,Tolbert, B.S. IRES-targeting small molecule inhibits enterovirus 71 replication via allosteric stabilization of a ternary complex. Nat Commun, 11:4775-4775, 2020 Cited by PubMed: 32963221 DOI: 10.1038/s41467-020-18594-3 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation