6WT7

Structure of a metazoan TIR-STING receptor from C. gigas in complex with 2',3'-cGAMP

Summary for 6WT7

• Entry DOI: 10.2210/pdb6wt7/pdb
• Descriptor: Metazoan TIR-STING fusion, cGAMP (2 entities in total)
• Functional Keywords: tir domain, cyclic dinucleotide receptor, immune effector, immune system
• Biological source: Crassostrea gigas
• Total number of polymer chains: 1
• Total formula weight: 47737.70

Authors

Morehouse, B.R.,Govande, A.A.,Millman, A.,Keszei, A.F.A.,Lowey, B.,Ofir, G.,Shao, S.,Sorek, R.,Kranzusch, P.J. (deposition date: 2020-05-01, release date: 2020-09-09, Last modification date: 2024-03-06)

• Primary citation: Morehouse, B.R.,Govande, A.A.,Millman, A.,Keszei, A.F.A.,Lowey, B.,Ofir, G.,Shao, S.,Sorek, R.,Kranzusch, P.J.; STING cyclic dinucleotide sensing originated in bacteria.; Nature, 586:429-433, 2020; PubMed: 32877915; DOI: 10.1038/s41586-020-2719-5

Experimental method

X-RAY DIFFRACTION (2.9 Å)