6WT7

Structure of a metazoan TIR-STING receptor from C. gigas in complex with 2',3'-cGAMP

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000045	biological_process	autophagosome assembly
A	0000166	molecular_function	nucleotide binding
A	0002218	biological_process	activation of innate immune response
A	0002376	biological_process	immune system process
A	0005776	cellular_component	autophagosome
A	0005789	cellular_component	endoplasmic reticulum membrane
A	0006914	biological_process	autophagy
A	0007165	biological_process	signal transduction
A	0016239	biological_process	positive regulation of macroautophagy
A	0016787	molecular_function	hydrolase activity
A	0032481	biological_process	positive regulation of type I interferon production
A	0035438	molecular_function	cyclic-di-GMP binding
A	0045087	biological_process	innate immune response
A	0051607	biological_process	defense response to virus
A	0061507	molecular_function	2',3'-cyclic GMP-AMP binding
A	0061709	biological_process	reticulophagy
A	0061809	molecular_function	NAD+ nucleotidase, cyclic ADP-ribose generating

Functional Information from PDB Data

site_id	AC1
Number of Residues	15
Details	binding site for residue 1SY A 501

Chain	Residue
A	GLY182
A	GLN257
A	TYR258
A	GLU278
A	GLY281
A	VAL282
A	VAL282
A	TYR183
A	TYR183
A	GLY186
A	GLY186
A	TYR187
A	TYR187
A	ARG256
A	ARG256

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: ACT_SITE => ECO:0000255|PROSITE-ProRule:PRU00204, ECO:0000305|PubMed:32877915

Chain	Residue	Details
A	GLU104

---

site_id	SWS_FT_FI2
Number of Residues	1
Details	BINDING: BINDING => ECO:0007744|PDB:6WT7

Chain	Residue	Details
A	ARG256

---