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6WT7

Structure of a metazoan TIR-STING receptor from C. gigas in complex with 2',3'-cGAMP

Functional Information from GO Data
ChainGOidnamespacecontents
A0000045biological_processautophagosome assembly
A0000166molecular_functionnucleotide binding
A0002218biological_processactivation of innate immune response
A0002376biological_processimmune system process
A0005776cellular_componentautophagosome
A0005789cellular_componentendoplasmic reticulum membrane
A0006914biological_processautophagy
A0007165biological_processsignal transduction
A0016239biological_processpositive regulation of macroautophagy
A0016787molecular_functionhydrolase activity
A0032481biological_processpositive regulation of type I interferon production
A0035438molecular_functioncyclic-di-GMP binding
A0045087biological_processinnate immune response
A0061507molecular_function2',3'-cyclic GMP-AMP binding
A0061709biological_processreticulophagy
A0061809molecular_functionNAD+ nucleosidase activity, cyclic ADP-ribose generating
Functional Information from PDB Data
site_idAC1
Number of Residues15
Detailsbinding site for residue 1SY A 501
ChainResidue
AGLY182
AGLN257
ATYR258
AGLU278
AGLY281
AVAL282
AVAL282
ATYR183
ATYR183
AGLY186
AGLY186
ATYR187
ATYR187
AARG256
AARG256

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"evidences":[{"source":"PROSITE-ProRule","id":"PRU00204","evidenceCode":"ECO:0000255"},{"source":"PubMed","id":"32877915","evidenceCode":"ECO:0000305"}]}
ChainResidueDetails

site_idSWS_FT_FI2
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PDB","id":"6WT7","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

242842

PDB entries from 2025-10-08

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