6HDU
 
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5OQZ
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7KX9
 | | Cryo-EM structure of Ephydatia fluviatilis PiwiA-piRNA-target complex | | 分子名称: | MAGNESIUM ION, Piwi-A, RNA (5'-R(P*UP*CP*UP*CP*UP*UP*GP*AP*GP*UP*UP*GP*GP*AP*CP*AP*AP*AP*UP*GP*GP*CP*AP*(OMG))-3'), ... | | 著者 | Anzelon, T.A, Chowdhury, S, Lander, G.C, MacRae, I.J. | | 登録日 | 2020-12-03 | | 公開日 | 2021-07-14 | | 最終更新日 | 2024-05-29 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural basis for piRNA targeting.
Nature, 597, 2021
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6F8A
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7B5G
 | | Crystal structure of E.coli LexA in complex with nanobody NbSOS3(Nb14527) | | 分子名称: | 1,2-ETHANEDIOL, LexA repressor, Nanobody Nb14527, ... | | 著者 | Maso, L, Vascon, F, Chinellato, M, Pardon, E, Steyaert, J, Angelini, A, Tondi, D, Cendron, L. | | 登録日 | 2020-12-03 | | 公開日 | 2022-09-14 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway.
Structure, 30, 2022
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3PF4
 | | Crystal structure of Bs-CspB in complex with r(GUCUUUA) | | 分子名称: | Cold shock protein cspB, MAGNESIUM ION, SODIUM ION, ... | | 著者 | Sachs, R, Max, K.E.A, Heinemann, U. | | 登録日 | 2010-10-27 | | 公開日 | 2011-09-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.38 Å) | | 主引用文献 | RNA single strands bind to a conserved surface of the major cold shock protein in crystals and solution.
Rna, 18, 2012
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8UF4
 | | Crystal structure of wildtype dystroglycan proteolytic domain (juxtamembrane domain) | | 分子名称: | Beta-dystroglycan, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Anderson, M.J.M, Shi, K, Hayward, A.N, Uhlens, C, Evans III, R.L, Grant, E, Greenberg, L, Aihara, H, Gordon, W.R. | | 登録日 | 2023-10-03 | | 公開日 | 2024-09-11 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | Structural and Functional Analysis of Dystroglycan Cell Surface Cleavage Reveals a Novel Regulation Mechanism
To Be Published
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2Y3Q
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7KWA
 | | Structure of DCN1 bound to N-((4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl)-3-(trifluoromethyl)benzamide | | 分子名称: | Endolysin,DCN1-like protein 1, N-[(4S,5S)-3-(aminomethyl)-7-ethyl-4-(4-fluorophenyl)-6-oxo-1-phenyl-4,5,6,7-tetrahydro-1H-pyrazolo[3,4-b]pyridin-5-yl]-3-(trifluoromethyl)benzamide | | 著者 | Kim, H.S, Hammill, J.T, Schulman, B.A, Guy, R.K, Scott, D.C. | | 登録日 | 2020-11-30 | | 公開日 | 2021-07-14 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.572 Å) | | 主引用文献 | Improvement of Oral Bioavailability of Pyrazolo-Pyridone Inhibitors of the Interaction of DCN1/2 and UBE2M.
J.Med.Chem., 64, 2021
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8KB4
 | | Cryo-EM structure of human TMEM87A A308M | | 分子名称: | (9R,12R)-15-amino-12-hydroxy-6,12-dioxo-7,11,13-trioxa-12lambda~5~-phosphapentadecan-9-yl undecanoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Transmembrane protein 87A,EGFP | | 著者 | Han, A, Kim, H.M. | | 登録日 | 2023-08-03 | | 公開日 | 2024-07-10 | | 最終更新日 | 2024-09-18 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | GolpHCat (TMEM87A), a unique voltage-dependent cation channel in Golgi apparatus, contributes to Golgi-pH maintenance and hippocampus-dependent memory.
Nat Commun, 15, 2024
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6BO9
 | | Cryo-EM structure of human TRPV6 in amphipols | | 分子名称: | Transient receptor potential cation channel subfamily V member 6 | | 著者 | McGoldrick, L.L, Singh, A.K, Saotome, K, Yelshanskaya, M.V, Twomey, E.C, Grassucci, R.A, Sobolevsky, A.I. | | 登録日 | 2017-11-18 | | 公開日 | 2017-12-20 | | 最終更新日 | 2024-03-13 | | 実験手法 | ELECTRON MICROSCOPY (4 Å) | | 主引用文献 | Opening of the human epithelial calcium channel TRPV6.
Nature, 553, 2018
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2Y2W
 | | Elucidation of the substrate specificity and protein structure of AbfB, a family 51 alpha-L-arabinofuranosidase from Bifidobacterium longum. | | 分子名称: | ARABINOFURANOSIDASE | | 著者 | Lagaert, S, Schoepe, J, Delcour, J.A, Lavigne, R, Strelkov, S.V, Courtin, C.M, Mikkelsen, N.E, Sandgren, M, Volckaert, G. | | 登録日 | 2010-12-16 | | 公開日 | 2011-12-28 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Elucidation of the Substrate Specificity and Protein Structure of Abfb, a Family 51 Alpha-L- Arabinofuranosidase from Bifidobacterium Longum.
To be Published
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5KOQ
 | | Discovery of TAK-272: A Novel, Potent and Orally Active Renin In-hibitor | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-~{tert}-butyl-4-(furan-2-ylmethylamino)-~{N}-(2-methylpropyl)-~{N}-[(3~{S})-piperidin-3-yl]pyrimidine-5-carboxamide, DI(HYDROXYETHYL)ETHER, ... | | 著者 | Snell, G.P, Behnke, C.A, Okada, K, Hideyuki, O, Sang, B.-C, Lane, W. | | 登録日 | 2016-07-01 | | 公開日 | 2016-11-02 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors.
Bioorg.Med.Chem., 24, 2016
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4IWR
 | | C.Esp1396I bound to a 25 base pair operator site | | 分子名称: | DNA (25-MER), Regulatory protein | | 著者 | Martin, R.N.A, McGeehan, J.E, Ball, N.J, Streeter, S.D, Thresh, S.-J, Kneale, G.G. | | 登録日 | 2013-01-24 | | 公開日 | 2013-09-11 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural analysis of DNA-protein complexes regulating the restriction-modification system Esp1396I.
Acta Crystallogr.,Sect.F, 69, 2013
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6BOX
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5V8F
 | | Structural basis of MCM2-7 replicative helicase loading by ORC-Cdc6 and Cdt1 | | 分子名称: | Cell division control protein 6, Cell division cycle protein CDT1, DNA (39-MER), ... | | 著者 | Yuan, Z, Riera, A, Bai, L, Sun, J, Spanos, C, Chen, Z.A, Barbon, M, Rappsilber, J, Stillman, B, Speck, C, Li, H. | | 登録日 | 2017-03-21 | | 公開日 | 2017-05-10 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | Structural basis of Mcm2-7 replicative helicase loading by ORC-Cdc6 and Cdt1.
Nat. Struct. Mol. Biol., 24, 2017
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6U4S
 | | wild type cysteine dioxygenase | | 分子名称: | Cysteine dioxygenase type 1, FE (III) ION | | 著者 | Meneely, K.M, Chilton, A.S, Forbes, D.L, Ellis, H.R, Lamb, A.L. | | 登録日 | 2019-08-26 | | 公開日 | 2020-07-08 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | The 3-His Metal Coordination Site Promotes the Coupling of Oxygen Activation to Cysteine Oxidation in Cysteine Dioxygenase.
Biochemistry, 59, 2020
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6FEJ
 | | Anabaena Apo-C-Terminal Domain Homolog Protein | | 分子名称: | All4940 protein, UREA | | 著者 | Harris, D, Wilson, A, Muzzopappa, F, Kirilovsky, D, Adir, N. | | 登録日 | 2018-01-02 | | 公開日 | 2018-07-18 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Structural rearrangements in the C-terminal domain homolog of Orange Carotenoid Protein are crucial for carotenoid transfer.
Commun Biol, 1, 2018
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6U4X
 | | Crystal structure of Equine Serum Albumin complex with ibuprofen | | 分子名称: | IBUPROFEN, SULFATE ION, Serum albumin, ... | | 著者 | Czub, M.P, Handing, K.B, Venkataramany, B.S, Steen, E.H, Shabalin, I.G, Satchell, K.J, Joachimiak, A, Minor, W, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2019-08-26 | | 公開日 | 2019-09-04 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Albumin-Based Transport of Nonsteroidal Anti-Inflammatory Drugs in Mammalian Blood Plasma.
J.Med.Chem., 63, 2020
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5N8A
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3PDO
 | | Crystal Structure of HLA-DR1 with CLIP102-120 | | 分子名称: | FORMIC ACID, GLYCEROL, HLA class II histocompatibility antigen gamma chain, ... | | 著者 | Gunther, S, Schlundt, A, Sticht, J, Roske, Y, Heinemann, U, Wiesmuller, K.-H, Jung, G, Falk, K, Rotzschke, O, Freund, C. | | 登録日 | 2010-10-23 | | 公開日 | 2010-12-08 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | | 主引用文献 | Bidirectional binding of invariant chain peptides to an MHC class II molecule.
Proc.Natl.Acad.Sci.USA, 107, 2010
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6Y62
 | | Crystal structure of the envelope glycoprotein complex of Maporal virus in a prefusion conformation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Envelope polyprotein,Envelope polyprotein, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | 著者 | Serris, A, Rey, F.A, Guardado-Calvo, P. | | 登録日 | 2020-02-26 | | 公開日 | 2020-10-14 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | The Hantavirus Surface Glycoprotein Lattice and Its Fusion Control Mechanism.
Cell, 183, 2020
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7JM2
 | | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with apramycin | | 分子名称: | APRAMYCIN, Aminocyclitol acetyltransferase ApmA, CHLORIDE ION | | 著者 | Stogios, P.J, Evdokimova, E, Di Leo, R, Bordeleau, E, Wright, G.D, Savchenko, A, Joachimiak, A, Satchell, K.J.F, Center for Structural Genomics of Infectious Diseases (CSGID) | | 登録日 | 2020-07-30 | | 公開日 | 2020-09-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Crystal structure of aminoglycoside resistance enzyme ApmA, complex with apramycin
To Be Published
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5D60
 | | Structure of Chaetomium thermophilum Skn7 coiled-coil domain, crystal form III | | 分子名称: | Putative transcription factor | | 著者 | Neudegger, T, Verghese, J, Hayer-Hartl, M, Hartl, F.U, Bracher, A. | | 登録日 | 2015-08-11 | | 公開日 | 2016-06-22 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structure of human heat-shock transcription factor 1 in complex with DNA.
Nat.Struct.Mol.Biol., 23, 2016
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6U5B
 | | CryoEM Structure of Pyocin R2 - precontracted - baseplate | | 分子名称: | Glue PA0627, Ripcord PA0626, Sheath Initiator PA0617, ... | | 著者 | Ge, P, Avaylon, J, Scholl, D, Shneider, M.M, Browning, C, Buth, S.A, Plattner, M, Ding, K, Leiman, P.G, Miller, J.F, Zhou, Z.H. | | 登録日 | 2019-08-27 | | 公開日 | 2020-04-15 | | 最終更新日 | 2024-03-20 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Action of a minimal contractile bactericidal nanomachine.
Nature, 580, 2020
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