6BOX

Structure of the S. pombe Clr4 catalytic domain bound to SAH

Summary for 6BOX

• Entry DOI: 10.2210/pdb6box/pdb
• Descriptor: Histone-lysine N-methyltransferase, H3 lysine-9 specific, ZINC ION, S-ADENOSYL-L-HOMOCYSTEINE, ... (4 entities in total)
• Functional Keywords: methyltransferase, set domain, transferase
• Biological source: Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
• Total number of polymer chains: 2
• Total formula weight: 69788.63

Authors

Currie, M.A.,Moazed, D. (deposition date: 2017-11-21, release date: 2018-07-25, Last modification date: 2023-10-04)

• Primary citation: Iglesias, N.,Currie, M.A.,Jih, G.,Paulo, J.A.,Siuti, N.,Kalocsay, M.,Gygi, S.P.,Moazed, D.; Automethylation-induced conformational switch in Clr4 (Suv39h) maintains epigenetic stability.; Nature, 560:504-508, 2018; PubMed: 30051891; DOI: 10.1038/s41586-018-0398-2

Experimental method

X-RAY DIFFRACTION (2.412 Å)