7CVY
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![BU of 7cvy by Molmil](/molmil-images/mine/7cvy) | Cryo-EM structure of Chikungunya virus in complex with Fab fragments of mAb CHK-124 | Descriptor: | Capsid protein, E1 glycoprotein, E2 glycoprotein, ... | Authors: | Zhou, Q.F, Fox, J.M, Earnest, J.T, Ng, T.S, Kim, A.S, Fibriansah, G, Kostyuchenko, V.A, Shu, B, Diamond, M.S, Lok, S.M. | Deposit date: | 2020-08-27 | Release date: | 2020-11-04 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (5.2 Å) | Cite: | Structural basis of Chikungunya virus inhibition by monoclonal antibodies. Proc.Natl.Acad.Sci.USA, 117, 2020
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4TXC
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![BU of 4txc by Molmil](/molmil-images/mine/4txc) | Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor | Descriptor: | 1,2-ETHANEDIOL, 4-(3-{3-[(R)-{[2-(dimethylamino)ethyl]amino}(hydroxy)methyl]phenyl}imidazo[1,2-b]pyridazin-6-yl)-2-methoxyphenol, Death-associated protein kinase 1 | Authors: | Sorrell, F.J, Krojer, T, Wilbek, T.S, Skovgaard, T, Berthelsen, J, Dixon-Clarke, S, Chalk, R, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Stromgaard, K, Knapp, S. | Deposit date: | 2014-07-03 | Release date: | 2014-07-23 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.951 Å) | Cite: | Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1. Chembiochem, 16, 2015
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4TXI
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![BU of 4txi by Molmil](/molmil-images/mine/4txi) | Construct of MICAL-1 containing the monooxygenase and calponin homology domains | Descriptor: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, FLAVIN-ADENINE DINUCLEOTIDE, ... | Authors: | Alqassim, S.S, Amzel, L.M, Bianchet, M.A. | Deposit date: | 2014-07-03 | Release date: | 2016-01-13 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.309 Å) | Cite: | Modulation of MICAL Monooxygenase Activity by its Calponin Homology Domain: Structural and Mechanistic Insights. Sci Rep, 6, 2016
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4U17
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![BU of 4u17 by Molmil](/molmil-images/mine/4u17) | Swapped dimer of the human Fyn-SH2 domain | Descriptor: | 1,2-ETHANEDIOL, PHOSPHATE ION, Tyrosine-protein kinase Fyn | Authors: | Garcia-Pino, A, Huculeci, R, Lenaerts, T, van Nuland, N.A.J. | Deposit date: | 2014-07-15 | Release date: | 2015-07-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.99 Å) | Cite: | Swapped dimer of the human Fyn-SH2 domain To Be Published
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6WLA
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![BU of 6wla by Molmil](/molmil-images/mine/6wla) | Antigen binding fragment of ch128.1 | Descriptor: | Fab ch128.1 heavy chain, Fab ch128.1 light chain, GLYCEROL | Authors: | Helguera, G, Rodriguez, J.A, Sawaya, M, Cascio, D, Zink, S, Ziegenbein, J, Short, C. | Deposit date: | 2020-04-18 | Release date: | 2021-03-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Host receptor-targeted therapeutic approach to counter pathogenic New World mammarenavirus infections. Nat Commun, 13, 2022
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4UAF
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4UBC
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![BU of 4ubc by Molmil](/molmil-images/mine/4ubc) | DNA polymerase beta substrate complex with a templating cytosine and incoming 8-oxodGTP, 0 s | Descriptor: | 5'-D(*CP*CP*GP*AP*CP*CP*GP*CP*GP*CP*AP*TP*CP*AP*GP*C)-3', 5'-D(*GP*CP*TP*GP*AP*TP*GP*CP*GP*C)-3', 5'-D(P*GP*TP*CP*GP*G)-3', ... | Authors: | Freudenthal, B.D, Wilson, S.H, Beard, W.A. | Deposit date: | 2014-08-12 | Release date: | 2014-11-12 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Uncovering the polymerase-induced cytotoxicity of an oxidized nucleotide. Nature, 517, 2015
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4TW3
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![BU of 4tw3 by Molmil](/molmil-images/mine/4tw3) | Insights into Substrate and Metal Binding from the Crystal Structure of Cyanobacterial Aldehyde Deformylating Oxygenase with Substrate Bound | Descriptor: | 1,2-ETHANEDIOL, Aldehyde decarbonylase, FE (III) ION, ... | Authors: | Buer, B.C, Paul, B, Das, D, Stuckey, J.A, Marsh, E.N.G. | Deposit date: | 2014-06-29 | Release date: | 2014-10-15 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Insights into substrate and metal binding from the crystal structure of cyanobacterial aldehyde deformylating oxygenase with substrate bound. Acs Chem.Biol., 9, 2014
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4TWI
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![BU of 4twi by Molmil](/molmil-images/mine/4twi) | The structure of Sir2Af1 bound to a succinylated histone peptide | Descriptor: | GLYCEROL, NAD-dependent protein deacylase 1, Succinylated H4 Peptide (aa8-20), ... | Authors: | Ringel, A.E, Roman, C, Wolberger, C. | Deposit date: | 2014-06-30 | Release date: | 2014-12-03 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Alternate deacylating specificities of the archaeal sirtuins Sir2Af1 and Sir2Af2. Protein Sci., 23, 2014
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4TZF
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![BU of 4tzf by Molmil](/molmil-images/mine/4tzf) | Structure of metallo-beta lactamase | Descriptor: | NDM-8 metallo-beta-lactamase, ZINC ION | Authors: | Ferguson, J.A, Makena, A, Brem, J, McDonough, M.A, Schofield, C.J. | Deposit date: | 2014-07-10 | Release date: | 2015-07-29 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.22 Å) | Cite: | structure of metallo-beta lactamase To Be Published
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4UWT
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![BU of 4uwt by Molmil](/molmil-images/mine/4uwt) | Hypocrea jecorina Cel7A E212Q mutant in complex with p-nitrophenyl cellobioside | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CELLOBIOHYDROLASE CEL7A, COBALT (II) ION, ... | Authors: | Nutt, A, Momeni, M.H, Johansson, G, Stahlberg, J. | Deposit date: | 2014-08-14 | Release date: | 2015-08-26 | Last modified: | 2024-01-31 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Enzyme kinetics by GH7 cellobiohydrolases on chromogenic substrates is dictated by non-productive binding: insights from crystal structures and MD simulation. Febs J., 2022
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7CNB
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4TWH
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![BU of 4twh by Molmil](/molmil-images/mine/4twh) | X-ray structure of a pentameric ligand gated ion channel from Erwinia chrysanthemi (ELIC) mutant F16'S | Descriptor: | Cys-loop ligand-gated ion channel | Authors: | Ulens, C, Spurny, R, Thompson, A.J, Alqazzaz, M, Debaveye, S, Lu, H, Price, K, Villalgordo, J.M, Tresadern, G, Lynch, J.W, Lummis, S.C.R. | Deposit date: | 2014-06-30 | Release date: | 2014-09-24 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | The Prokaryote Ligand-Gated Ion Channel ELIC Captured in a Pore Blocker-Bound Conformation by the Alzheimer's Disease Drug Memantine. Structure, 22, 2014
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4U4V
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![BU of 4u4v by Molmil](/molmil-images/mine/4u4v) | Structure of a nitrate/nitrite antiporter NarK in apo inward-open state | Descriptor: | NICKEL (II) ION, Nitrate/nitrite transporter NarK, OLEIC ACID | Authors: | Fukuda, M, Takeda, H, Kato, H.E, Doki, S, Ito, K, Maturana, A.D, Ishitani, R, Nureki, O. | Deposit date: | 2014-07-24 | Release date: | 2015-07-15 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural basis for dynamic mechanism of nitrate/nitrite antiport by NarK Nat Commun, 6, 2015
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4U2B
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4U2E
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![BU of 4u2e by Molmil](/molmil-images/mine/4u2e) | Crystal structure of dienelactone hydrolase S-3 variant (Q35H, F38L, Q110L, C123S, Y137C, Y145C, N154D, E199G, S208G, G211D and K234N) at 1.70 A resolution | Descriptor: | Carboxymethylenebutenolidase, SULFATE ION | Authors: | Porter, J.L, Collyer, C.A, Ollis, D.L. | Deposit date: | 2014-07-16 | Release date: | 2014-12-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Directed evolution of new and improved enzyme functions using an evolutionary intermediate and multidirectional search. Acs Chem.Biol., 10, 2015
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4U07
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![BU of 4u07 by Molmil](/molmil-images/mine/4u07) | ATP bound to eukaryotic FIC domain containing protein | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Adenosine monophosphate-protein transferase FICD, MAGNESIUM ION, ... | Authors: | Cole, A.R, Bunney, T.D, Katan, M. | Deposit date: | 2014-07-11 | Release date: | 2014-12-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.64 Å) | Cite: | Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions. Structure, 22, 2014
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4U0S
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![BU of 4u0s by Molmil](/molmil-images/mine/4u0s) | Structure of Eukaryotic fic domain containing protein with ADP | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Adenosine monophosphate-protein transferase FICD, MAGNESIUM ION, ... | Authors: | Cole, A.R, Katan, M, Bunney, T.D. | Deposit date: | 2014-07-14 | Release date: | 2014-12-10 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Crystal structure of the human, FIC-domain containing protein HYPE and implications for its functions. Structure, 22, 2014
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4U9P
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![BU of 4u9p by Molmil](/molmil-images/mine/4u9p) | Structure of the methanofuran/methanopterin biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii | Descriptor: | GLYCEROL, UPF0264 protein MJ1099 | Authors: | Bobik, T.A, Morales, E, Shin, A, Cascio, D, Sawaya, M.R, Arbing, M, Rasche, M.E. | Deposit date: | 2014-08-06 | Release date: | 2014-11-12 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of the methanofuran/methanopterin-biosynthetic enzyme MJ1099 from Methanocaldococcus jannaschii. Acta Crystallogr.,Sect.F, 70, 2014
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6X60
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![BU of 6x60 by Molmil](/molmil-images/mine/6x60) | ClpP2 from Chlamydia trachomatis with resolved handle loop | Descriptor: | ATP-dependent Clp protease proteolytic subunit 2 | Authors: | Azadmanesh, J, Struble, L.R, Seleem, M.A, Ouellette, S, Conda-Sheridan, M, Borgstahl, G.E.O. | Deposit date: | 2020-05-27 | Release date: | 2020-06-03 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | ClpP2 from Chlamydia trachomatis with resolved handle loop To Be Published
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4U2C
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![BU of 4u2c by Molmil](/molmil-images/mine/4u2c) | Crystal structure of dienelactone hydrolase A-6 variant (S7T, A24V, Q35H, F38L, Q110L, C123S, Y145C, E199G and S208G) at 1.95 A resolution | Descriptor: | Carboxymethylenebutenolidase, SULFATE ION | Authors: | Porter, J.L, Collyer, C.A, Ollis, D.L. | Deposit date: | 2014-07-16 | Release date: | 2014-12-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Directed evolution of new and improved enzyme functions using an evolutionary intermediate and multidirectional search. Acs Chem.Biol., 10, 2015
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4U2D
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![BU of 4u2d by Molmil](/molmil-images/mine/4u2d) | Crystal structure of dienelactone hydrolase S-2 variant (Q35H, F38L, Q110L, C123S, Y137C, Y145C, N154D, E199G, S208G and G211D) at 1.67 A resolution | Descriptor: | Carboxymethylenebutenolidase, SULFATE ION | Authors: | Porter, J.L, Collyer, C.A, Ollis, D.L. | Deposit date: | 2014-07-16 | Release date: | 2014-12-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.67 Å) | Cite: | Directed evolution of new and improved enzyme functions using an evolutionary intermediate and multidirectional search. Acs Chem.Biol., 10, 2015
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4U2G
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![BU of 4u2g by Molmil](/molmil-images/mine/4u2g) | Crystal structure of dienelactone hydrolase B-4 variant (Q35H, F38L, Y64H, Q76L, Q110L, C123S, Y137C, A141V, Y145C, N154D, E199G, S208G, G211D, S233G and 237Q) at 1.80 A resolution | Descriptor: | Carboxymethylenebutenolidase, SULFATE ION | Authors: | Porter, J.L, Collyer, C.A, Ollis, D.L. | Deposit date: | 2014-07-16 | Release date: | 2014-12-10 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Directed evolution of new and improved enzyme functions using an evolutionary intermediate and multidirectional search. Acs Chem.Biol., 10, 2015
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3KSN
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![BU of 3ksn by Molmil](/molmil-images/mine/3ksn) | Crystal structure of the lipoprotein localization factor, LolA | Descriptor: | Outer-membrane lipoprotein carrier protein | Authors: | Ahmadpour, F, Gloyd, M, Guarne, A, Stewart, G, Pathania, R, Brown, E.D. | Deposit date: | 2009-11-23 | Release date: | 2010-10-06 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Crystal structure of the lipoprotein localization factor, LolA To be Published
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4W8H
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![BU of 4w8h by Molmil](/molmil-images/mine/4w8h) | |