4TXC

Crystal Structure of DAPK1 kinase domain in complex with a small molecule inhibitor

Summary for 4TXC

Entry DOI	10.2210/pdb4txc/pdb
Related	2YAK 4PF4
Descriptor	Death-associated protein kinase 1, 4-(3-{3-[(R)-{[2-(dimethylamino)ethyl]amino}(hydroxy)methyl]phenyl}imidazo[1,2-b]pyridazin-6-yl)-2-methoxyphenol, 1,2-ETHANEDIOL, ... (4 entities in total)
Functional Keywords	protein-ligand complex, kinase, small-molecule, catalytic domain, protein kinase, protein binding, protein kinase inhibitors, transferase
Biological source	Homo sapiens (Human)
Cellular location	Isoform 1: Cytoplasm. Isoform 2: Cytoplasm: P53355
Total number of polymer chains	1
Total formula weight	35571.33
Authors	Sorrell, F.J.,Krojer, T.,Wilbek, T.S.,Skovgaard, T.,Berthelsen, J.,Dixon-Clarke, S.,Chalk, R.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Stromgaard, K.,Knapp, S. (deposition date: 2014-07-03, release date: 2014-07-23, Last modification date: 2023-12-20)
Primary citation	Wilbek, T.S.,Skovgaard, T.,Sorrell, F.J.,Knapp, S.,Berthelsen, J.,Strmgaard, K. Identification and characterization of a small-molecule inhibitor of death-associated protein kinase 1. Chembiochem, 16:59-63, 2015 Cited by PubMed: 25382253 DOI: 10.1002/cbic.201402512 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.951 Å)

Structure validation