4YUT
| Crystal structure of photoactivated adenylyl cyclase of a cyanobacteriaOscillatoria acuminata in orthorhombic form | Descriptor: | FLAVIN MONONUCLEOTIDE, Family 3 adenylate cyclase | Authors: | Park, S.-Y, Ohki, M, Sugiyama, K, Kawai, F, Iseki, M. | Deposit date: | 2015-03-19 | Release date: | 2016-06-01 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural insight into photoactivation of an adenylate cyclase from a photosynthetic cyanobacterium Proc.Natl.Acad.Sci.USA, 113, 2016
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5XY9
| Structure of the MST4 and 14-3-3 complex | Descriptor: | 14-3-3 protein zeta/delta, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, GLYCEROL, ... | Authors: | Shi, Z.B, Zhou, Z.C. | Deposit date: | 2017-07-06 | Release date: | 2018-07-11 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.303 Å) | Cite: | Structure of the MST4 and 14-3-3 complex To Be Published
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4OUM
| Crystal structure of human Caprin-2 C1q domain | Descriptor: | CITRATE ANION, Caprin-2, ISOPROPYL ALCOHOL, ... | Authors: | Song, X, Li, L. | Deposit date: | 2014-02-18 | Release date: | 2014-10-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.491 Å) | Cite: | Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling J.Biol.Chem., 289, 2014
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4OUS
| Crystal structure of zebrafish Caprin-2 C1q domain | Descriptor: | CALCIUM ION, Caprin-2 | Authors: | Song, X, Li, L. | Deposit date: | 2014-02-18 | Release date: | 2014-10-29 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling J.Biol.Chem., 289, 2014
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4OUL
| Crystal structure of human Caprin-2 C1q domain | Descriptor: | CALCIUM ION, Caprin-2, GLYCEROL | Authors: | Song, X, Li, L. | Deposit date: | 2014-02-17 | Release date: | 2014-10-29 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.949 Å) | Cite: | Structural insights into the C1q domain of Caprin-2 in canonical Wnt signaling J.Biol.Chem., 289, 2014
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8ZU2
| Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8g | Descriptor: | 2-azanyl-5-[2-(1,4-diazepan-1-yl)pyridin-4-yl]-3-(2,6-dimethyl-3-oxidanyl-phenyl)benzamide, GLYCINE, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | Authors: | Zhang, Z.M, Zhou, Z.Q. | Deposit date: | 2024-06-07 | Release date: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.79888582 Å) | Cite: | Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1 -Amplified Breast Cancer. J.Med.Chem., 2024
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8ZUL
| Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8m | Descriptor: | 2-azanyl-5-[2-[(3~{R})-3-azanylpyrrolidin-1-yl]pyridin-4-yl]-3-(2,6-dimethyl-3-oxidanyl-phenyl)benzamide, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | Authors: | Zhang, Z.M, Zhou, Z.Q. | Deposit date: | 2024-06-09 | Release date: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.80026162 Å) | Cite: | Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1 -Amplified Breast Cancer. J.Med.Chem., 2024
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8ZUD
| Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8f | Descriptor: | 2-azanyl-3-(2,6-dimethyl-3-oxidanyl-phenyl)-5-(2-morpholin-4-ylpyridin-4-yl)benzamide, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | Authors: | Zhang, Z.M, Zhou, Z.Q. | Deposit date: | 2024-06-08 | Release date: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.50510085 Å) | Cite: | Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1 -Amplified Breast Cancer. J.Med.Chem., 2024
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8ZTX
| Crystal Structure of Human Myt1 Kinase domain Bounded with compound 6b | Descriptor: | 2-azanyl-3-(2,6-dimethyl-3-oxidanyl-phenyl)-5-pyridin-4-yl-benzamide, Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase | Authors: | Zhang, Z.M, Zhou, Z.Q. | Deposit date: | 2024-06-07 | Release date: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.70033228 Å) | Cite: | Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1 -Amplified Breast Cancer. J.Med.Chem., 2024
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7EP0
| Crystal structure of ZYG11B bound to GSTE degron | Descriptor: | Protein zyg-11 homolog B, sodium 3,3'-(1E,1'E)-biphenyl-4,4'-diylbis(diazene-2,1-diyl)bis(4-aminonaphthalene-1-sulfonate) | Authors: | Yan, X, Li, Y. | Deposit date: | 2021-04-26 | Release date: | 2021-07-14 | Last modified: | 2021-09-01 | Method: | X-RAY DIFFRACTION (2.16 Å) | Cite: | Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell, 81, 2021
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7EP3
| Crystal structure of ZER1 bound to GAGN degron | Descriptor: | Protein zer-1 homolog | Authors: | Yan, X, Li, Y. | Deposit date: | 2021-04-26 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.513 Å) | Cite: | Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell, 81, 2021
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7EP2
| Crystal structure of ZYG11B bound to GGFN degron | Descriptor: | Protein zyg-11 homolog B | Authors: | Yan, X, Li, Y. | Deposit date: | 2021-04-26 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.38 Å) | Cite: | Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell, 81, 2021
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7EP5
| Crystal structure of ZER1 bound to GKLH degron | Descriptor: | Protein zer-1 homolog | Authors: | Yan, X, Li, Y. | Deposit date: | 2021-04-26 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell, 81, 2021
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7EP1
| Crystal structure of ZYG11B bound to GFLH degron | Descriptor: | Protein zyg-11 homolog B | Authors: | Yan, X, Li, Y. | Deposit date: | 2021-04-26 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.852 Å) | Cite: | Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell, 81, 2021
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7EP4
| Crystal structure of ZER1 bound to GFLH degron | Descriptor: | Protein zer-1 homolog | Authors: | Yan, X, Li, Y. | Deposit date: | 2021-04-26 | Release date: | 2021-07-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.07 Å) | Cite: | Molecular basis for recognition of Gly/N-degrons by CRL2 ZYG11B and CRL2 ZER1 . Mol.Cell, 81, 2021
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6M4G
| Structural mechanism of nucleosome dynamics governed by human histone variants H2A.B and H2A.Z.2.2 | Descriptor: | DNA (93-MER), Histone H2A-Bbd type 2/3, Histone H2B type 2-E, ... | Authors: | Zhou, M, Dai, L.C, Li, C.M, Shi, L.X, Huang, Y, Guo, Z.Q. | Deposit date: | 2020-03-06 | Release date: | 2020-09-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (2.8 Å) | Cite: | Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2. Embo J., 40, 2021
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6M4H
| Structural mechanism of nucleosome dynamics governed by human histone variants H2A.B and H2A.Z.2.2 | Descriptor: | DNA (103-MER), Histone H2A-Bbd type 2/3, Histone H2B type 2-E, ... | Authors: | Zhou, M, Dai, L.C, Li, C.M, Shi, L.X, Huang, Y, Guo, Z.Q. | Deposit date: | 2020-03-07 | Release date: | 2020-09-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2. Embo J., 40, 2021
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6M4D
| Structural mechanism of nucleosome dynamics governed by human histone variants H2A.B and H2A.Z.2.2 | Descriptor: | DNA (125-MER), Histone H2A.V, Histone H2B type 2-E, ... | Authors: | Zhou, M, Dai, L.C, Li, C.M, Shi, L.X, Huang, Y, Guo, Z.Q. | Deposit date: | 2020-03-06 | Release date: | 2020-09-23 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Structural basis of nucleosome dynamics modulation by histone variants H2A.B and H2A.Z.2.2. Embo J., 40, 2021
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8TVP
| Cryo-EM structure of CPD-stalled Pol II in complex with Rad26 (open state) | Descriptor: | DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ... | Authors: | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | Deposit date: | 2023-08-18 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVV
| Cryo-EM structure of backtracked Pol II | Descriptor: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | Deposit date: | 2023-08-18 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVY
| Cryo-EM structure of CPD lesion containing RNA Polymerase II elongation complex with Rad26 and Elf1 (closed state) | Descriptor: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | Deposit date: | 2023-08-18 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVQ
| Cryo-EM structure of CPD stalled 10-subunit Pol II in complex with Rad26 | Descriptor: | DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ... | Authors: | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | Deposit date: | 2023-08-18 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (4.6 Å) | Cite: | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVX
| Cryo-EM structure of CPD-stalled Pol II (Conformation 2) | Descriptor: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | Deposit date: | 2023-08-18 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVW
| Cryo-EM structure of CPD-stalled Pol II (conformation 1) | Descriptor: | DNA (NTS), DNA (TS), DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | Deposit date: | 2023-08-18 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc.Natl.Acad.Sci.USA, 121, 2024
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8TVS
| Cryo-EM structure of backtracked Pol II in complex with Rad26 | Descriptor: | DNA (NTS), DNA (TS), DNA repair and recombination protein RAD26, ... | Authors: | Sarsam, R.D, Lahiri, I, Leschziner, A.E. | Deposit date: | 2023-08-18 | Release date: | 2024-01-24 | Method: | ELECTRON MICROSCOPY (4.4 Å) | Cite: | Elf1 promotes Rad26's interaction with lesion-arrested Pol II for transcription-coupled repair. Proc.Natl.Acad.Sci.USA, 121, 2024
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