8ZUL

Crystal Structure of Human Myt1 Kinase domain Bounded with compound 8m

This is a non-PDB format compatible entry.

Summary for 8ZUL

• Entry DOI: 10.2210/pdb8zul/pdb
• Descriptor: Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase, 2-azanyl-5-[2-[(3~{R})-3-azanylpyrrolidin-1-yl]pyridin-4-yl]-3-(2,6-dimethyl-3-oxidanyl-phenyl)benzamide (3 entities in total)
• Functional Keywords: protein kinase, gene regulation
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 32128.58

Authors

Zhang, Z.M.,Zhou, Z.Q. (deposition date: 2024-06-09, release date: 2024-09-11, Last modification date: 2024-09-25)

• Primary citation: Wang, C.,Fang, Y.,Zhou, Z.,Liu, Z.,Feng, F.,Wan, X.,Li, Y.,Liu, S.,Ding, J.,Zhang, Z.M.,Xie, H.,Lu, X.; Structure-Based Drug Design of 2-Amino-[1,1'-biphenyl]-3-carboxamide Derivatives as Selective PKMYT1 Inhibitors for the Treatment of CCNE1 -Amplified Breast Cancer.; J.Med.Chem., 67:15816-15836, 2024; PubMed: 39163619; DOI: 10.1021/acs.jmedchem.4c01458

Experimental method

X-RAY DIFFRACTION (1.80026162696 Å)