8ED8
| cryo-EM structure of TRPM3 ion channel in the presence of PIP2 and PregS, state 1 | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2022-09-03 | Release date: | 2022-11-02 | Last modified: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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8ED9
| cryo-EM structure of TRPM3 ion channel in the presence with PIP2 and PregS, state 2 | Descriptor: | (3beta,14beta,17beta,25R)-3-[4-methoxy-3-(methoxymethyl)butoxy]spirost-5-en, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, SODIUM ION, ... | Authors: | Zhao, C, MacKinnon, R. | Deposit date: | 2022-09-03 | Release date: | 2022-11-09 | Last modified: | 2023-01-18 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron, 111, 2023
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7V9Q
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7V9P
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7V9O
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7V9N
| Crystal structure of the lanthipeptide zinc-metallopeptidase EryP from saccharopolyspora erythraea in closed state | Descriptor: | ACETATE ION, Alanine aminopeptidase, CALCIUM ION, ... | Authors: | Zhao, C, Zhao, N.L, Bao, R. | Deposit date: | 2021-08-26 | Release date: | 2022-05-11 | Last modified: | 2022-07-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Conformational remodeling enhances activity of lanthipeptide zinc-metallopeptidases. Nat.Chem.Biol., 18, 2022
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8I5N
| Rat Kir4.1 in complex with PIP2 and Lys05 | Descriptor: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Zhao, C, Guo, J. | Deposit date: | 2023-01-26 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses To Be Published
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8I5M
| Rat Kir4.1 in complex with PIP2 | Descriptor: | ATP-sensitive inward rectifier potassium channel 10, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate | Authors: | Zhao, C, Guo, J. | Deposit date: | 2023-01-26 | Release date: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.85 Å) | Cite: | Pharmacological inhibition of astrocytic Kir4.1 channel evokes rapid-onset antidepressant responses To Be Published
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7WRA
| Mouse TRPM8 in LMNG in ligand-free state | Descriptor: | SODIUM ION, Transient receptor potential cation channel subfamily M member 8 | Authors: | Zhao, C, Xie, Y, Guo, J. | Deposit date: | 2022-01-26 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (2.98 Å) | Cite: | Structures of a mammalian TRPM8 in closed state. Nat Commun, 13, 2022
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7WRF
| Mouse TRPM8 in lipid nanodiscs in the presence of calcium, icilin and PI(4,5)P2 | Descriptor: | CALCIUM ION, Icilin, SODIUM ION, ... | Authors: | Zhao, C, Xie, Y, Guo, J. | Deposit date: | 2022-01-26 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.04 Å) | Cite: | Structures of a mammalian TRPM8 in closed state. Nat Commun, 13, 2022
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7WRD
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7WRB
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7WRC
| Mouse TRPM8 in LMNG in the presence of calcium, icilin and PI(4,5)P2 | Descriptor: | CALCIUM ION, Icilin, Transient receptor potential cation channel subfamily M member 8 | Authors: | Zhao, C, Xie, Y, Guo, J. | Deposit date: | 2022-01-26 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.21 Å) | Cite: | Structures of a mammalian TRPM8 in closed state. Nat Commun, 13, 2022
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7WRE
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7EW4
| Cryo-EM structure of CYM-5541-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. | Deposit date: | 2021-05-24 | Release date: | 2021-09-29 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
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7EW2
| Cryo-EM structure of pFTY720-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | Descriptor: | (2~{S})-2-azanyl-4-(4-octylphenyl)-2-[[oxidanyl-bis(oxidanylidene)-$l^{6}-phosphanyl]oxymethyl]butan-1-ol, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. | Deposit date: | 2021-05-24 | Release date: | 2021-09-29 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
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7EW3
| Cryo-EM structure of S1P-bound Sphingosine 1-phosphate receptor 3 in complex with Gi protein | Descriptor: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, C, Wang, W, Wang, H.L, Shao, Z.H. | Deposit date: | 2021-05-24 | Release date: | 2021-09-29 | Last modified: | 2022-02-16 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structural insights into sphingosine-1-phosphate recognition and ligand selectivity of S1PR3-Gi signaling complexes. Cell Res., 32, 2022
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5Y91
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5N3U
| The structure of the complex of CpcE and CpcF of phycocyanin lyase from Nostoc sp. PCC7120 | Descriptor: | Phycocyanobilin lyase subunit alpha, Phycocyanobilin lyase subunit beta | Authors: | Hoeppner, A, Zhao, C, Xu, Q.-Z, Gaertner, W, Scheer, H, Zhao, K.-H. | Deposit date: | 2017-02-09 | Release date: | 2017-12-06 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Structures and enzymatic mechanisms of phycobiliprotein lyases CpcE/F and PecE/F. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7BOV
| The Structure of Bacillus subtilis glycosyltransferase,Bs-YjiC | Descriptor: | GLYCEROL, SODIUM ION, Uncharacterized UDP-glucosyltransferase YjiC | Authors: | Zhao, C, Liu, B, Zhao, N.L, Luo, Y.Z, Bao, R. | Deposit date: | 2020-03-20 | Release date: | 2020-05-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.293 Å) | Cite: | Structural and biochemical studies of the glycosyltransferase Bs-YjiC from Bacillus subtilis. Int.J.Biol.Macromol., 166, 2021
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8JZ7
| Cryo-EM structure of MK-6892-bound HCAR2 in complex with Gi protein | Descriptor: | 2-[[2,2-dimethyl-3-[3-(5-oxidanylpyridin-2-yl)-1,2,4-oxadiazol-5-yl]propanoyl]amino]cyclohexene-1-carboxylic acid, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhao, C, Tian, X.W, Liu, Y, Cheng, L, Yan, W, Shao, Z.H. | Deposit date: | 2023-07-04 | Release date: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Orthosteric ligand selectivity and allosteric probe dependence at Hydroxycarboxylic acid receptor HCAR2. Signal Transduct Target Ther, 8, 2023
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5YKW
| Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems | Descriptor: | Thioredoxin-3, mitochondrial, peptide THR-PRO-VAL-CYS-THR-THR-GLU-VAL | Authors: | Li, C.C, Yang, J, Yang, M.J, Liu, L, Peng, C.T, Li, T, He, L.H, Song, Y.J, Zhu, Y.B, Zhao, N.L, Zhao, C, Bao, R. | Deposit date: | 2017-10-16 | Release date: | 2018-10-24 | Last modified: | 2019-11-06 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Structural basis of the thiol resolving mechanism in yeast mitochondrial 1-Cys peroxiredoxin via glutathione/thioredoxin systems to be published
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7BOR
| Structure of Pseudomonas aeruginosa CoA-bound OdaA | Descriptor: | COENZYME A, Probable enoyl-CoA hydratase/isomerase | Authors: | Zhao, N, Zhao, C, Liu, L, Li, T, Li, C, He, L, Zhu, Y, Song, Y, Bao, R. | Deposit date: | 2020-03-19 | Release date: | 2020-05-13 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.901 Å) | Cite: | Structural and molecular dynamic studies of Pseudomonas aeruginosa OdaA reveal the regulation role of a C-terminal hinge element. Biochim Biophys Acta Gen Subj, 1865, 2020
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8SAI
| Cryo-EM structure of GPR34-Gi complex | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | Yong, X.H, Zhao, C, Yan, W, Shao, Z.H. | Deposit date: | 2023-04-01 | Release date: | 2023-10-04 | Method: | ELECTRON MICROSCOPY (3.27 Å) | Cite: | Cryo-EM structures of human GPR34 enable the identification of selective antagonists. Proc.Natl.Acad.Sci.USA, 120, 2023
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6JAU
| The complex structure of Pseudomonas aeruginosa MucA/MucB. | Descriptor: | CALCIUM ION, GLYCEROL, HEXAETHYLENE GLYCOL, ... | Authors: | Li, T, He, L.H, Li, C.C, Liu, L, Peng, C.T, Shen, Y.L, Qin, X.F, Xiao, Q.J, Zhu, Y.B, Song, Y.J, Zhao, N.l, Zhao, C, Yang, J, Mu, X.Y, Huang, Q, Bao, R. | Deposit date: | 2019-01-25 | Release date: | 2020-01-29 | Last modified: | 2020-08-19 | Method: | X-RAY DIFFRACTION (1.905 Å) | Cite: | Molecular basis of the lipid-induced MucA-MucB dissociation in Pseudomonas aeruginosa. Commun Biol, 3, 2020
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