7XT9
| Serotonin 4 (5-HT4) receptor-Gs complex | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Huang, S, Xu, P, Shen, D.D, Simon, I.A, Mao, C, Tan, Y, Zhang, H, Harpsoe, K, Li, H, Zhang, Y, You, C, Yu, X, Jiang, Y, Zhang, Y, Gloriam, D.E, Xu, H.E. | Deposit date: | 2022-05-16 | Release date: | 2022-07-27 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.2 Å) | Cite: | GPCRs steer G i and G s selectivity via TM5-TM6 switches as revealed by structures of serotonin receptors. Mol.Cell, 82, 2022
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7DFB
| Crystal of Arrestin2-V2Rpp-6-7-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.28 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7DF9
| Crystal of Arrestin2-V2Rpp-1-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (3.17 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7DFA
| Crystal of Arrestin2-V2Rpp-4-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.54 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7DFC
| Crystal of Arrestin2-V2Rpp-3-Fab30 complex | Descriptor: | Beta-arrestin-1, FAB30 HEAVY CHAIN, FAB30 LIGHT CHAIN, ... | Authors: | Sun, J.P, Yu, X, Xiao, P, He, Q.T, Lin, J.Y, Zhu, Z.L. | Deposit date: | 2020-11-06 | Release date: | 2021-07-28 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.49 Å) | Cite: | Structural studies of phosphorylation-dependent interactions between the V2R receptor and arrestin-2. Nat Commun, 12, 2021
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7ETJ
| C5 portal vertex in the partially-enveloped virion capsid | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | Authors: | Li, Z, Yu, X. | Deposit date: | 2021-05-13 | Release date: | 2021-07-14 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis for genome packaging, retention, and ejection in human cytomegalovirus. Nat Commun, 12, 2021
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7ETM
| C6 portal vertex in the enveloped virion capsid | Descriptor: | Portal protein | Authors: | Li, Z, Yu, X. | Deposit date: | 2021-05-13 | Release date: | 2021-07-14 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (5.9 Å) | Cite: | Structural basis for genome packaging, retention, and ejection in human cytomegalovirus. Nat Commun, 12, 2021
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7ET2
| Human Cytomegalovirus, C12 portal | Descriptor: | Portal protein | Authors: | Li, Z, Yu, X. | Deposit date: | 2021-05-12 | Release date: | 2021-07-14 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis for genome packaging, retention, and ejection in human cytomegalovirus. Nat Commun, 12, 2021
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7ETO
| C1 CVSC-binding penton vertex in the virion capsid of Human Cytomegalovirus | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | Authors: | Li, Z, Yu, X. | Deposit date: | 2021-05-13 | Release date: | 2021-07-14 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural basis for genome packaging, retention, and ejection in human cytomegalovirus. Nat Commun, 12, 2021
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7ET3
| C5 portal vertex in the enveloped virion capsid | Descriptor: | Capsid vertex component 1, Capsid vertex component 2, Large tegument protein deneddylase, ... | Authors: | Li, Z, Yu, X. | Deposit date: | 2021-05-12 | Release date: | 2021-07-14 | Last modified: | 2021-08-18 | Method: | ELECTRON MICROSCOPY (4.2 Å) | Cite: | Structural basis for genome packaging, retention, and ejection in human cytomegalovirus. Nat Commun, 12, 2021
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3JB0
| Atomic model of cytoplasmic polyhedrosis virus with GTP | Descriptor: | Capsid protein VP1, GUANOSINE-5'-TRIPHOSPHATE, Structural protein VP3, ... | Authors: | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | Deposit date: | 2015-07-06 | Release date: | 2015-08-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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3JAZ
| Atomic model of cytoplasmic polyhedrosis virus with ATP | Descriptor: | Capsid protein VP1, Structural protein VP3, Viral structural protein 5 | Authors: | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | Deposit date: | 2015-07-06 | Release date: | 2015-08-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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3JB2
| Atomic model of cytoplasmic polyhedrosis virus with SAM and GTP | Descriptor: | Capsid protein VP1, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | Deposit date: | 2015-07-06 | Release date: | 2015-08-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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3JAY
| Atomic model of transcribing cytoplasmic polyhedrosis virus | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Capsid protein VP1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | Deposit date: | 2015-07-06 | Release date: | 2015-08-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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3JB1
| Atomic model of cytoplasmic polyhedrosis virus with SAM | Descriptor: | Capsid protein VP1, S-ADENOSYLMETHIONINE, Structural protein VP3, ... | Authors: | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | Deposit date: | 2015-07-06 | Release date: | 2015-08-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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3JB3
| Atomic model of cytoplasmic polyhedrosis virus with SAM, GTP and ATP | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Capsid protein VP1, GUANOSINE-5'-TRIPHOSPHATE, ... | Authors: | Yu, X.K, Jiang, J.S, Sun, J.C, Zhou, Z.H. | Deposit date: | 2015-07-06 | Release date: | 2015-08-12 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | A putative ATPase mediates RNA transcription and capping in a dsRNA virus. Elife, 4, 2015
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6FAX
| Complex of Human CD40 Ectodomain with Lob 7.4 Fab | Descriptor: | Lob 7.4 heavy chain, Lob 7.4 light chain, Tumor necrosis factor receptor superfamily member 5 | Authors: | Orr, C.M, Tews, I, Pearson, A.R. | Deposit date: | 2017-12-18 | Release date: | 2018-02-07 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.99 Å) | Cite: | Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies. Cancer Cell, 33, 2018
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4LD7
| Crystal structure of AnaPT from Neosartorya fischeri | Descriptor: | Dimethylallyl tryptophan synthase, SODIUM ION, TRIHYDROGEN THIODIPHOSPHATE | Authors: | Zocher, G, Stehle, T. | Deposit date: | 2013-06-24 | Release date: | 2013-12-11 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Catalytic Mechanism of Stereospecific Formation of cis-Configured Prenylated Pyrroloindoline Diketopiperazines by Indole Prenyltransferases. Chem.Biol., 20, 2013
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7VQ1
| Structure of Apo-hsTRPM2 channel | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | Deposit date: | 2021-10-18 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.76 Å) | Cite: | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Rep, 37, 2021
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7VQ2
| Structure of Apo-hsTRPM2 channel TM domain | Descriptor: | Transient receptor potential cation channel subfamily M member 2 | Authors: | Yu, X.F, Xie, Y, Zhang, X.K, Ma, C, Guo, J.T, Yang, F, Yang, W. | Deposit date: | 2021-10-18 | Release date: | 2021-12-22 | Method: | ELECTRON MICROSCOPY (3.68 Å) | Cite: | Structural and functional basis of the selectivity filter as a gate in human TRPM2 channel. Cell Rep, 37, 2021
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5XLS
| Crystal structure of UraA in occluded conformation | Descriptor: | 12-TUNGSTOPHOSPHATE, URACIL, Uracil permease | Authors: | Yu, X.Z, Yang, G.H, Yan, C.Y, Yan, N. | Deposit date: | 2017-05-11 | Release date: | 2017-07-05 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Dimeric structure of the uracil:proton symporter UraA provides mechanistic insights into the SLC4/23/26 transporters Cell Res., 27, 2017
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7JTO
| Crystal structure of Protac MS33 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | Descriptor: | 1,2-ETHANEDIOL, 3-methyl-N-(11-{[2-(4-{[4'-(4-methylpiperazin-1-yl)-3'-{[6-oxo-4-(trifluoromethyl)-5,6-dihydropyridine-3-carbonyl]amino}[1,1'-biphenyl]-3-yl]methyl}piperazin-1-yl)ethyl]amino}-11-oxoundecanoyl)-L-valyl-(4R)-4-hydroxy-N-{[4-(4-methyl-1,3-thiazol-5-yl)phenyl]methyl}-L-prolinamide, Elongin-B, ... | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | Deposit date: | 2020-08-18 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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7JTP
| Crystal structure of Protac MS67 in complex with the WD repeat-containing protein 5 and pVHL:ElonginC:ElonginB | Descriptor: | Elongin-B, Elongin-C, GLYCEROL, ... | Authors: | Kottur, J, Jain, R, Aggarwal, A.K. | Deposit date: | 2020-08-18 | Release date: | 2021-10-06 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.12 Å) | Cite: | A selective WDR5 degrader inhibits acute myeloid leukemia in patient-derived mouse models. Sci Transl Med, 13, 2021
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7ROV
| KRAS G12D Mutant in complex with GMPPCP and cyclic peptide MP-9903 | Descriptor: | Cyclic peptide MP-9903, GLYCEROL, Isoform 2B of GTPase KRas, ... | Authors: | Orth, P. | Deposit date: | 2021-08-02 | Release date: | 2021-09-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | Discovery of cell active macrocyclic peptides with on-target inhibition of KRAS signaling. Chem Sci, 12, 2021
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8JLP
| Ralmitaront(RO-6889450)-bound hTAAR1-Gs protein complex | Descriptor: | 5-ethyl-4-methyl-~{N}-[4-[(2~{S})-morpholin-2-yl]phenyl]-1~{H}-pyrazole-3-carboxamide, Gs, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Xu, Z, Guo, L.L, Zhao, C, Shen, S.Y, Sun, J.P, Shao, Z.H. | Deposit date: | 2023-06-02 | Release date: | 2023-11-15 | Last modified: | 2024-01-03 | Method: | ELECTRON MICROSCOPY (3.23 Å) | Cite: | Ligand recognition and G-protein coupling of trace amine receptor TAAR1. Nature, 624, 2023
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