6FAX

Complex of Human CD40 Ectodomain with Lob 7.4 Fab

Summary for 6FAX

Entry DOI	10.2210/pdb6fax/pdb
Descriptor	Lob 7.4 light chain, Lob 7.4 heavy chain, Tumor necrosis factor receptor superfamily member 5, ... (4 entities in total)
Functional Keywords	cd40, engineered fab, agonist, mab, immune system
Biological source	Homo sapiens More
Cellular location	Isoform I: Cell membrane; Single-pass type I membrane protein. Isoform II: Secreted: P25942
Total number of polymer chains	3
Total formula weight	68515.46
Authors	Orr, C.M.,Tews, I.,Pearson, A.R. (deposition date: 2017-12-18, release date: 2018-02-07, Last modification date: 2024-01-17)
Primary citation	Yu, X.,Chan, H.T.C.,Orr, C.M.,Dadas, O.,Booth, S.G.,Dahal, L.N.,Penfold, C.A.,O'Brien, L.,Mockridge, C.I.,French, R.R.,Duriez, P.,Douglas, L.R.,Pearson, A.R.,Cragg, M.S.,Tews, I.,Glennie, M.J.,White, A.L. Complex Interplay between Epitope Specificity and Isotype Dictates the Biological Activity of Anti-human CD40 Antibodies. Cancer Cell, 33:664-675.e4, 2018 Cited by PubMed: 29576376 DOI: 10.1016/j.ccell.2018.02.009 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.99 Å)

Structure validation