1LB5
| TRAF6-RANK Complex | Descriptor: | TNF receptor-associated factor 6, receptor activator of nuclear factor-kappa B | Authors: | Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H. | Deposit date: | 2002-04-02 | Release date: | 2002-07-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Distinct molecular mechanism for initiating TRAF6 signalling. Nature, 418, 2002
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1LB4
| TRAF6 apo structure | Descriptor: | TNF receptor-associated factor 6 | Authors: | Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H. | Deposit date: | 2002-04-02 | Release date: | 2002-07-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Distinct molecular mechanism for initiating TRAF6 signalling. Nature, 418, 2002
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1LB6
| TRAF6-CD40 Complex | Descriptor: | CD40 antigen, TNF receptor-associated factor 6 | Authors: | Ye, H, Arron, J.R, Lamothe, B, Cirilli, M, Kobayashi, T, Shevde, N.K, Segal, D, Dzivenu, O, Vologodskaia, M, Yim, M, Du, K, Singh, S, Pike, J.W, Darnay, B.G, Choi, Y, Wu, H. | Deposit date: | 2002-04-02 | Release date: | 2002-07-31 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Distinct molecular mechanism for initiating TRAF6 signalling. Nature, 418, 2002
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1M6I
| Crystal Structure of Apoptosis Inducing Factor (AIF) | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, Programmed cell death protein 8 | Authors: | Ye, H, Cande, C, Stephanou, N.C, Jiang, S, Gurbuxani, S, Larochette, N, Daugas, E, Garrido, C, Kroemer, G, Wu, H. | Deposit date: | 2002-07-16 | Release date: | 2002-08-28 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | DNA binding is required for the apoptogenic action of apoptosis inducing factor. Nat.Struct.Biol., 9, 2002
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1PM3
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1D0A
| STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 (TRAF2) IN COMPLEX WITH A HUMAN OX40 PEPTIDE | Descriptor: | OX40L RECEPTOR PEPTIDE, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2 | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | Deposit date: | 1999-09-09 | Release date: | 2000-03-08 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol.Cell, 4, 1999
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1D0J
| STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A M4-1BB PEPTIDE | Descriptor: | 4-1BB LIGAND RECEPTOR, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2 | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | Deposit date: | 1999-09-10 | Release date: | 2000-03-08 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol.Cell, 4, 1999
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1CZZ
| STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 17-RESIDUE CD40 PEPTIDE | Descriptor: | CD 40 PEPTIDE, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2 | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | Deposit date: | 1999-09-07 | Release date: | 2000-03-08 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol.Cell, 4, 1999
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1D00
| STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A 5-RESIDUE CD40 PEPTIDE | Descriptor: | B-CELL SURFACE ANTIGEN CD40, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2 | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | Deposit date: | 1999-09-07 | Release date: | 2000-03-29 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol.Cell, 4, 1999
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1D01
| STRUCTURE OF TNF RECEPTOR ASSOCIATED FACTOR 2 IN COMPLEX WITH A HUMAN CD30 PEPTIDE | Descriptor: | CD30 PEPTIDE, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 2 | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | Deposit date: | 1999-09-07 | Release date: | 2003-12-02 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol.Cell, 4, 1999
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1CZY
| CRYSTAL STRUCTURE OF THE COMPLEX BETWEEN THE TRAF DOMAIN OF HUMAN TRAF2 AND AN LMP1 BINDING PEPTIDE | Descriptor: | LATENT MEMBRANE PROTEIN 1, TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED PROTEIN 2 | Authors: | Ye, H, Park, Y.C, Kreishman, M, Kieff, E, Wu, H. | Deposit date: | 1999-09-07 | Release date: | 2000-03-08 | Last modified: | 2018-01-31 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The structural basis for the recognition of diverse receptor sequences by TRAF2. Mol.Cell, 4, 1999
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2L9L
| NMR Structure of the Mouse MFG-E8 C2 Domain | Descriptor: | Lactadherin | Authors: | Ye, H, Yoon, H.S. | Deposit date: | 2011-02-21 | Release date: | 2012-08-29 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | NMR solution structure of C2 domain of MFG-E8 and insights into its molecular recognition with phosphatidylserine Biochim.Biophys.Acta, 1828, 2013
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1F3V
| Crystal structure of the complex between the N-terminal domain of TRADD and the TRAF domain of TRAF2 | Descriptor: | TUMOR NECROSIS FACTOR RECEPTOR TYPE 1 ASSOCIATED DEATH DOMAIN PROTEIN, TUMOR NECROSIS FACTOR RECEPTOR-ASSOCIATED PROTEIN | Authors: | Park, Y.C, Ye, H, Hsia, C, Segal, D, Rich, R, Liou, H.-C, Myszka, D, Wu, H. | Deposit date: | 2000-06-06 | Release date: | 2000-09-06 | Last modified: | 2017-10-04 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | A novel mechanism of TRAF signaling revealed by structural and functional analyses of the TRADD-TRAF2 interaction. Cell(Cambridge,Mass.), 101, 2000
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2MF9
| Solution structure of the N-terminal domain of human FKBP38 (FKBP38NTD) | Descriptor: | Peptidyl-prolyl cis-trans isomerase FKBP8 | Authors: | Kang, C, Ye, H, Simon, B, Sattler, M, Yoon, H.S. | Deposit date: | 2013-10-08 | Release date: | 2013-11-06 | Last modified: | 2024-05-01 | Method: | SOLUTION NMR | Cite: | Functional role of the flexible N-terminal extension of FKBP38 in catalysis. Sci Rep, 3, 2013
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6D4B
| Crystal structure of Candida boidinii formate dehydrogenase V123A mutant complexed with NAD+ and azide | Descriptor: | AZIDE ION, CHLORIDE ION, Formate dehydrogenase, ... | Authors: | Guo, Q, Ye, H, Gakhar, L, Cheatum, C.M, Kohen, A. | Deposit date: | 2018-04-17 | Release date: | 2019-04-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase Acs Catalysis, 2019
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6D4C
| Crystal structure of Candida boidinii formate dehydrogenase V123G mutant complexed with NAD+ and azide | Descriptor: | AZIDE ION, CHLORIDE ION, Formate dehydrogenase, ... | Authors: | Guo, Q, Ye, H, Gakhar, L, Cheatum, C.M, Kohen, A. | Deposit date: | 2018-04-17 | Release date: | 2019-04-24 | Last modified: | 2023-10-04 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Oscillatory Active-site Motions Correlate with Kinetic Isotope Effects in Formate Dehydrogenase Acs Catalysis, 2019
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2OFN
| Solution structure of FK506-binding domain (FKBD)of FKBP35 from Plasmodium falciparum | Descriptor: | 70 kDa peptidylprolyl isomerase, putative | Authors: | Kang, C.B, Ye, H, Yoon, H.R, Yoon, H.S. | Deposit date: | 2007-01-04 | Release date: | 2007-12-25 | Last modified: | 2024-05-15 | Method: | SOLUTION NMR | Cite: | Solution structure of FK506 binding domain (FKBD) of Plasmodium falciparum FK506 binding protein 35 (PfFKBP35). Proteins, 70, 2007
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3HTK
| Crystal structure of Mms21 and Smc5 complex | Descriptor: | E3 SUMO-protein ligase MMS21, Structural maintenance of chromosomes protein 5, ZINC ION | Authors: | Duan, X, Sarangi, P, Liu, X, Rangi, G.K, Zhao, X, Ye, H. | Deposit date: | 2009-06-11 | Release date: | 2009-10-20 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.31 Å) | Cite: | Structural and functional insights into the roles of the Mms21 subunit of the Smc5/6 complex. Mol.Cell, 35, 2009
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2OW3
| Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor | Descriptor: | BIS-(INDOLE)MALEIMIDE PYRIDINOPHANE, Glycogen synthase kinase-3 beta | Authors: | Zhang, H.C, Bonaga, L.V, Ye, H, Derian, C.K, Damiano, B.P, Maryanoff, B.E. | Deposit date: | 2007-02-15 | Release date: | 2008-02-19 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3. Bioorg.Med.Chem.Lett., 17, 2007
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2VN1
| Crystal structure of the FK506-binding domain of Plasmodium falciparum FKBP35 in complex with FK506 | Descriptor: | 70 KDA PEPTIDYLPROLYL ISOMERASE, 8-DEETHYL-8-[BUT-3-ENYL]-ASCOMYCIN | Authors: | Kotaka, M, Alag, R, Ye, H, Preiser, P.R, Yoon, H.S, Lescar, J. | Deposit date: | 2008-01-30 | Release date: | 2008-05-20 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Crystal Structure of the Fk506 Binding Domain of Plasmodium Falciparum Fkbp35 in Complex with Fk506. Biochemistry, 47, 2008
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4PPI
| Crystal structure of Bcl-xL hexamer | Descriptor: | Bcl-2-like protein 1, GLYCEROL | Authors: | Sreekanth, R, Yoon, H.S. | Deposit date: | 2014-02-27 | Release date: | 2015-03-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.851 Å) | Cite: | Structural transition in Bcl-xL and its potential association with mitochondrial calcium ion transport Sci Rep, 5, 2015
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3V81
| Crystal structure of HIV-1 reverse transcriptase (RT) with DNA and the nonnucleoside inhibitor nevirapine | Descriptor: | 11-CYCLOPROPYL-5,11-DIHYDRO-4-METHYL-6H-DIPYRIDO[3,2-B:2',3'-E][1,4]DIAZEPIN-6-ONE, DNA (5'-D(*A*CP*AP*GP*TP*CP*CP*CP*TP*GP*TP*TP*CP*GP*GP*(MRG)P*CP*GP*CP*CP*(ATM))-3'), DNA (5'-D(*AP*TP*GP*GP*AP*AP*GP*GP*CP*GP*CP*CP*CP*GP*AP*AP*CP*AP*GP*GP*GP*AP*CP*TP*GP*TP*G)-3'), ... | Authors: | Das, K, Martinez, S.E, Arnold, E. | Deposit date: | 2011-12-22 | Release date: | 2012-01-18 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.8503 Å) | Cite: | HIV-1 reverse transcriptase complex with DNA and nevirapine reveals non-nucleoside inhibition mechanism. Nat.Struct.Mol.Biol., 19, 2012
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7DP8
| Crystal structure of T2R-TTL-Cevipabulin-eribulin complex | Descriptor: | (1S,3S,6S,9S,12S,14R,16R,18S,20R,21R,22S,26R,29S,31R,32S,33R,35R,36S)-20-[(2S)-3-amino-2-hydroxypropyl]-21-methoxy-14-methyl-8,15-dimethylidene-2,19,30,34,37,39,40,41-octaoxanonacyclo[24.9.2.1~3,32~.1~3,33~.1~6,9~.1~12,16~.0~18,22~.0~29,36~.0~31,35~]hentetracontan-24-one (non-preferred name), 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-[2,6-bis(fluoranyl)-4-[3-(methylamino)propoxy]phenyl]-5-chloranyl-N-[(2S)-1,1,1-tris(fluoranyl)propan-2-yl]-[1,2,4]triazolo[1,5-a]pyrimidin-7-amine, ... | Authors: | Chen, L.J, Chen, Q, Yu, Y, Yang, J.H. | Deposit date: | 2020-12-18 | Release date: | 2021-07-07 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.446 Å) | Cite: | Cevipabulin-tubulin complex reveals a novel agent binding site on alpha-tubulin with tubulin degradation effect. Sci Adv, 7, 2021
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7YRZ
| Crystal structure of HCoV 229E main protease in complex with PF07321332 | Descriptor: | (1R,2S,5S)-N-{(1E,2S)-1-imino-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}-6,6-dimethyl-3-[3-methyl-N-(trifluoroacetyl)-L-valyl]-3-azabicyclo[3.1.0]hexane-2-carboxamide, 3C-like proteinase | Authors: | Zhou, Y.R, Zeng, P, Zhou, X.L, Lin, C, Zhang, J, Yin, X.S, Li, J. | Deposit date: | 2022-08-11 | Release date: | 2023-08-16 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural basis of main proteases of HCoV-229E bound to inhibitor PF-07304814 and PF-07321332. Biochem.Biophys.Res.Commun., 657, 2023
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1S6Q
| CRYSTAL STRUCTURE OF HIV-1 REVERSE TRANSCRIPTASE (RT) IN COMPLEX WITH JANSSEN-R147681 | Descriptor: | 4-[4-(2,4,6-TRIMETHYL-PHENYLAMINO)-PYRIMIDIN-2-YLAMINO]-BENZONITRILE, POL polyprotein [Contains: Reverse transcriptase] | Authors: | Das, K, Arnold, E. | Deposit date: | 2004-01-26 | Release date: | 2004-05-11 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Roles of Conformational and Positional Adaptability in Structure-Based Design of TMC125-R165335 (Etravirine) and Related Non-nucleoside Reverse Transcriptase Inhibitors That Are Highly Potent and Effective against Wild-Type and Drug-Resistant HIV-1 Variants. J.Med.Chem., 47, 2004
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