2OW3

Glycogen synthase kinase-3 beta in complex with bis-(indole)maleimide pyridinophane inhibitor

Summary for 2OW3

• Entry DOI: 10.2210/pdb2ow3/pdb
• Descriptor: Glycogen synthase kinase-3 beta, BIS-(INDOLE)MALEIMIDE PYRIDINOPHANE (3 entities in total)
• Functional Keywords: kinase-inhibitor complex, transferase
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm : P49841
• Total number of polymer chains: 2
• Total formula weight: 81251.28

Authors

Zhang, H.C.,Bonaga, L.V.,Ye, H.,Derian, C.K.,Damiano, B.P.,Maryanoff, B.E. (deposition date: 2007-02-15, release date: 2008-02-19, Last modification date: 2023-11-15)

• Primary citation: Zhang, H.C.,Bonaga, L.V.,Ye, H.,Derian, C.K.,Damiano, B.P.,Maryanoff, B.E.; Novel bis(indolyl)maleimide pyridinophanes that are potent, selective inhibitors of glycogen synthase kinase-3.; Bioorg.Med.Chem.Lett., 17:2863-2868, 2007; PubMed: 17350261; DOI: 10.1016/j.bmcl.2007.02.059

Experimental method

X-RAY DIFFRACTION (2.8 Å)