2OJU
 
 | |
2OK3
 | | X-ray structure of human cyclophilin J at 2.0 angstrom | | 分子名称: | NICKEL (II) ION, Peptidyl-prolyl cis-trans isomerase-like 3 | | 著者 | Xia, Z. | | 登録日 | 2007-01-15 | | 公開日 | 2008-01-22 | | 最終更新日 | 2023-10-25 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Targeting Cyclophilin J, a novel peptidyl-prolyl isomerase, can induce cellular G1/S arrest and repress the growth of Hepatocellular carcinoma
To be Published
|
|
1G72
 | | CATALYTIC MECHANISM OF QUINOPROTEIN METHANOL DEHYDROGENASE: A THEORETICAL AND X-RAY CRYSTALLOGRAPHIC INVESTIGATION | | 分子名称: | CALCIUM ION, METHANOL DEHYDROGENASE HEAVY SUBUNIT, METHANOL DEHYDROGENASE LIGHT SUBUNIT, ... | | 著者 | Zheng, Y, Xia, Z, Chen, Z, Bruice, T.C, Mathews, F.S. | | 登録日 | 2000-11-08 | | 公開日 | 2001-01-24 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Catalytic mechanism of quinoprotein methanol dehydrogenase: A theoretical and x-ray crystallographic investigation.
Proc.Natl.Acad.Sci.USA, 98, 2001
|
|
1YZX
 | | Crystal structure of human kappa class glutathione transferase | | 分子名称: | Glutathione S-transferase kappa 1, L-GAMMA-GLUTAMYL-3-SULFINO-L-ALANYLGLYCINE | | 著者 | Li, J, Xia, Z, Ding, J. | | 登録日 | 2005-02-28 | | 公開日 | 2005-11-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | | 主引用文献 | Thioredoxin-like domain of human kappa class glutathione transferase reveals sequence homology and structure similarity to the theta class enzyme
PROTEIN SCI., 14, 2005
|
|
4P5A
 | | Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br UMP | | 分子名称: | 5-BROMO-URIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, Thymidylate synthase ThyX | | 著者 | Li, Y, Chen, W, Li, J, Xia, Z, Deng, Z, Zhou, J. | | 登録日 | 2014-03-15 | | 公開日 | 2015-12-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi with 5-Br UMP
To Be Published
|
|
4P5B
 | | Crystal structure of a UMP/dUMP methylase PolB from Streptomyces cacaoi bound with 5-Br dUMP | | 分子名称: | 5-BROMO-2'-DEOXYURIDINE-5'-MONOPHOSPHATE, FLAVIN-ADENINE DINUCLEOTIDE, SULFATE ION, ... | | 著者 | Li, Y, Chen, W, Li, J, Xia, Z, Deng, Z, Zhou, J. | | 登録日 | 2014-03-15 | | 公開日 | 2015-12-09 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.274 Å) | | 主引用文献 | Crystal structure of a UMP/dUMP methylase PolB form Streptomyces cacaoi bound with 5-Br dUMP
To Be Published
|
|
4IP3
 | | Complex structure of OspI and Ubc13 | | 分子名称: | ORF169b, Ubiquitin-conjugating enzyme E2 N | | 著者 | Fu, P, Jin, M, Zhang, X, Xu, L, Xia, Z, Zhu, Y. | | 登録日 | 2013-01-09 | | 公開日 | 2013-03-20 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structure Analysis of Ubc13 Inactivation
To be Published
|
|
4AAH
 | | METHANOL DEHYDROGENASE FROM METHYLOPHILUS W3A1 | | 分子名称: | CALCIUM ION, METHANOL DEHYDROGENASE, PYRROLOQUINOLINE QUINONE | | 著者 | Mathews, F.S, Xia, Z.-X. | | 登録日 | 1996-03-10 | | 公開日 | 1996-12-07 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Determination of the gene sequence and the three-dimensional structure at 2.4 angstroms resolution of methanol dehydrogenase from Methylophilus W3A1.
J.Mol.Biol., 259, 1996
|
|
7LYI
 | | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-3 | | 分子名称: | 3C-like proteinase, GLYCEROL, SODIUM ION, ... | | 著者 | Sacco, M, Wang, J, Chen, Y. | | 登録日 | 2021-03-07 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir.
Acs Pharmacol Transl Sci, 4, 2021
|
|
7LYH
 | | Crystal structure of the SARS-CoV-2 (COVID-19) main protease in complex with inhibitor UAWJ9-36-1 | | 分子名称: | 3C-like proteinase, GLYCEROL, benzyl (1S,3aR,6aS)-1-({(2S)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}carbamoyl)hexahydrocyclopenta[c]pyrrole-2(1H)-carboxylate | | 著者 | Sacco, M, Wang, J, Chen, Y. | | 登録日 | 2021-03-07 | | 公開日 | 2021-03-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Rational Design of Hybrid SARS-CoV-2 Main Protease Inhibitors Guided by the Superimposed Cocrystal Structures with the Peptidomimetic Inhibitors GC-376, Telaprevir, and Boceprevir.
Acs Pharmacol Transl Sci, 4, 2021
|
|
8X16
 | | Cryo-EM structure of adenosine receptor A3AR bound to CF101 | | 分子名称: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cai, H, Xu, Y, Xu, H.E. | | 登録日 | 2023-11-06 | | 公開日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.29 Å) | | 主引用文献 | Cryo-EM structures of adenosine receptor A3AR bound to selective agonists
Nat Commun, 15, 2024
|
|
8X17
 | | Cryo-EM structure of adenosine receptor A3AR bound to CF102 | | 分子名称: | Adenosine receptor A3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | 著者 | Cai, H, Xu, Y, Xu, H.E. | | 登録日 | 2023-11-06 | | 公開日 | 2024-04-24 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Cryo-EM structures of adenosine receptor A3AR bound to selective agonists
Nat Commun, 15, 2024
|
|
3H42
 | | Crystal structure of PCSK9 in complex with Fab from LDLR competitive antibody | | 分子名称: | Fab from LDLR competitive antibody: Heavy chain, Fab from LDLR competitive antibody: Light chain, Proprotein convertase subtilisin/kexin type 9, ... | | 著者 | Piper, D.E, Walker, N.P.C, Romanow, W.G, Thibault, S.T, Tsai, M.M, Yang, E. | | 登録日 | 2009-04-17 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | From the Cover: A proprotein convertase subtilisin/kexin type 9 neutralizing antibody reduces serum cholesterol in mice and nonhuman primates.
Proc.Natl.Acad.Sci.USA, 106, 2009
|
|
7RN0
 | |
7RN1
 | |
6OF8
 | | Structure of Thr354Asn, Glu355Gln, Thr412Asn, Ile414Met, Ile464His, and Phe467Met mutant human CamKII-alpha hub domain | | 分子名称: | Calcium/calmodulin-dependent protein kinase type II subunit alpha, GLYCEROL, POTASSIUM ION | | 著者 | McSpadden, E.D, Chi, C.C, Gee, C.L, Kuriyan, J. | | 登録日 | 2019-03-28 | | 公開日 | 2019-04-17 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Variation in assembly stoichiometry in non-metazoan homologs of the hub domain of Ca2+/calmodulin-dependent protein kinase II.
Protein Sci., 28, 2019
|
|
6OF9
 | |
4FFW
 | | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with Fab + sitagliptin | | 分子名称: | (2R)-4-OXO-4-[3-(TRIFLUOROMETHYL)-5,6-DIHYDRO[1,2,4]TRIAZOLO[4,3-A]PYRAZIN-7(8H)-YL]-1-(2,4,5-TRIFLUOROPHENYL)BUTAN-2-A MINE, Dipeptidyl peptidase 4, Fab heavy chain, ... | | 著者 | Wang, Z, Sudom, A, Walker, N.P, Min, X. | | 登録日 | 2012-06-01 | | 公開日 | 2012-12-12 | | 最終更新日 | 2021-05-19 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition
To be published
|
|
4FFV
 | | Crystal Structure of Dipeptidyl Peptidase IV (DPP4, DPP-IV, CD26) in Complex with 11A19 Fab | | 分子名称: | 11A19 Fab heavy chain, 11A19 Fab light chain, Dipeptidyl peptidase 4 | | 著者 | Wang, Z, Sudom, A, Walker, N.P, Min, X. | | 登録日 | 2012-06-01 | | 公開日 | 2012-12-12 | | 最終更新日 | 2021-05-19 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | An Inhibitory Antibody Against DPP IV Improves Glucose Tolerance in vivo - Validation of Large Molecule Approach for DPP IV Inhibition
To be published
|
|
6U7P
 | | HIV-1 wild type protease with GRL-03119A, with phenyl-boronic-acid as P2'-ligand and with a hexahydro-4H-furo-pyran as the P2-ligand | | 分子名称: | CHLORIDE ION, FORMIC ACID, GLYCEROL, ... | | 著者 | Wang, Y.-F, Kneller, D.W, Weber, I.T. | | 登録日 | 2019-09-03 | | 公開日 | 2019-10-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies.
Chemmedchem, 14, 2019
|
|
6U7O
 | | HIV-1 wild type protease with GRL-00819A, with phenyl-boronic-acid as P2'-ligand and with a 6-5-5-ring fused crown-like tetrahydropyranofuran as the P2-ligand | | 分子名称: | CHLORIDE ION, FORMIC ACID, GLYCEROL, ... | | 著者 | Wang, Y.-F, Kneller, D.W, Weber, I.T. | | 登録日 | 2019-09-03 | | 公開日 | 2019-10-09 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | | 主引用文献 | Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies.
Chemmedchem, 14, 2019
|
|
8WPG
 | | Human calcium-sensing receptor bound with cinacalcet in detergent | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Ling, S.L, Meng, X.Y, Tian, C.L. | | 登録日 | 2023-10-10 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | | 主引用文献 | Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.
Cell Res., 34, 2024
|
|
8WPU
 | | Human calcium-sensing receptor(CaSR) bound to cinacalcet in complex with Gq protein | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | | 著者 | Ling, S.L, Meng, X.Y, Tian, C.L. | | 登録日 | 2023-10-10 | | 公開日 | 2023-11-22 | | 最終更新日 | 2024-02-21 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Structural insights into asymmetric activation of the calcium-sensing receptor-G q complex.
Cell Res., 34, 2024
|
|
8XJ4
 | | Structure of prostatic acid phosphatase in human semen | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Prostatic acid phosphatase, alpha-D-mannopyranose, ... | | 著者 | Liu, X.Z, Li, J.L, Deng, D, Wang, X. | | 登録日 | 2023-12-20 | | 公開日 | 2024-02-28 | | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | | 主引用文献 | Purification, identification and Cryo-EM structure of prostatic acid phosphatase in human semen
Biochem.Biophys.Res.Commun., 702, 2024
|
|
1RYA
 | | Crystal Structure of the E. coli GDP-mannose mannosyl hydrolase in complex with GDP and MG | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, GDP-mannose mannosyl hydrolase, ... | | 著者 | Gabelli, S.B, Bianchet, M.A, Legler, P.M, Mildvan, A.S, Amzel, L.M. | | 登録日 | 2003-12-20 | | 公開日 | 2004-06-22 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | Structure and mechanism of GDP-mannose glycosyl hydrolase, a Nudix enzyme that cleaves at carbon instead of phosphorus.
Structure, 12, 2004
|
|
