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6U7P

HIV-1 wild type protease with GRL-03119A, with phenyl-boronic-acid as P2'-ligand and with a hexahydro-4H-furo-pyran as the P2-ligand

Summary for 6U7P
Entry DOI10.2210/pdb6u7p/pdb
Related2IEN 4I8W 4I8Z 6C8X 6U7O
DescriptorProtease, {4-[{(2R,3S)-3-[({[(3aS,4S,7aR)-hexahydro-4H-furo[2,3-b]pyran-4-yl]oxy}carbonyl)amino]-2-hydroxy-4-phenylbutyl}(2-methylpropyl)sulfamoyl]phenyl}boronic acid, SODIUM ION, ... (7 entities in total)
Functional Keywordsaspartic acid protease, hiv-1 protease inhibitor of grl-03119a, boronic acid, viral protein
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains2
Total formula weight22410.22
Authors
Wang, Y.-F.,Kneller, D.W.,Weber, I.T. (deposition date: 2019-09-03, release date: 2019-10-09, Last modification date: 2023-10-11)
Primary citationGhosh, A.K.,Xia, Z.,Kovela, S.,Robinson, W.L.,Johnson, M.E.,Kneller, D.W.,Wang, Y.F.,Aoki, M.,Takamatsu, Y.,Weber, I.T.,Mitsuya, H.
Potent HIV-1 Protease Inhibitors Containing Carboxylic and Boronic Acids: Effect on Enzyme Inhibition and Antiviral Activity and Protein-Ligand X-ray Structural Studies.
Chemmedchem, 14:1863-1872, 2019
Cited by
PubMed: 31549492
DOI: 10.1002/cmdc.201900508
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.13 Å)
Structure validation

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