4I8W
Crystal structure of wild type HIV-1 protease in complex with non-peptidic inhibitor, GRL007
Summary for 4I8W
| Entry DOI | 10.2210/pdb4i8w/pdb |
| Related | 4HLA 4I8Z |
| Descriptor | Protease, 4-{[(2R,3S)-3-({[(3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yloxy]carbonyl}amino)-2-hydroxy-4-phenylbutyl](2-methylpropyl)sulfamoyl}benzoic acid (3 entities in total) |
| Functional Keywords | hiv-1 protease, hiv-1 protease-inhibitor complex, hydrolase, grl007, protease inhibitor, non-peptidic protease inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Human immunodeficiency virus type 1 (HIV-1) |
| Cellular location | Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P0C6F2 |
| Total number of polymer chains | 2 |
| Total formula weight | 22184.17 |
| Authors | Yedidi, R.S.,Palmer, I.,Das, D.,Wingfield, P.T.,Ghosh, A.K.,Mitsuya, H. (deposition date: 2012-12-04, release date: 2013-07-24, Last modification date: 2024-02-28) |
| Primary citation | Yedidi, R.S.,Maeda, K.,Fyvie, W.S.,Steffey, M.,Davis, D.A.,Palmer, I.,Aoki, M.,Kaufman, J.D.,Stahl, S.J.,Garimella, H.,Das, D.,Wingfield, P.T.,Ghosh, A.K.,Mitsuya, H. P2' benzene carboxylic acid moiety is associated with decrease in cellular uptake: evaluation of novel non-peptidic HIV-1 protease inhibitors containing P2 bis-tetrahydrofuran moiety. Antimicrob.Agents Chemother., 57:4920-4927, 2013 Cited by PubMed: 23877703DOI: 10.1128/AAC.00868-13 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.96 Å) |
Structure validation
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