5YIU
| Caulobacter crescentus GcrA DNA-binding domain (DBD) | Descriptor: | Cell cycle regulatory protein GcrA | Authors: | Wu, X, Zhang, Y. | Deposit date: | 2017-10-06 | Release date: | 2018-03-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.42 Å) | Cite: | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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5YIW
| Caulobacter crescentus GcrA DNA-binding domain (DBD) in complex with methylated dsDNA (crystal form 2) | Descriptor: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*(6MA)P*TP*TP*CP*GP*C)-3'), ... | Authors: | Wu, X, Zhang, Y. | Deposit date: | 2017-10-06 | Release date: | 2018-03-21 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.551 Å) | Cite: | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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5YIV
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5YIX
| Caulobacter crescentus GcrA sigma-interacting domain (SID) in complex with domain 2 of sigma 70 | Descriptor: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, RNA polymerase sigma factor RpoD, ... | Authors: | Wu, X, Zhang, Y. | Deposit date: | 2017-10-06 | Release date: | 2018-03-21 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.302 Å) | Cite: | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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5Z7I
| Caulobacter crescentus GcrA DNA-binding domain(DBD)in complex with unmethylated dsDNA | Descriptor: | (R,R)-2,3-BUTANEDIOL, Cell cycle regulatory protein GcrA, DNA (5'-D(*CP*CP*CP*TP*GP*AP*TP*TP*CP*GP*C*)-3'), ... | Authors: | Wu, X, Zhang, Y. | Deposit date: | 2018-01-29 | Release date: | 2018-03-21 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.601 Å) | Cite: | Structural insights into the unique mechanism of transcription activation by Caulobacter crescentus GcrA. Nucleic Acids Res., 46, 2018
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7XQE
| Crystal Structure of human RORgamma (C455E) LBD in complex with compound XY039 | Descriptor: | 2,4-difluoro-N-(1-((4-(trifluoromethyl)benzyl)sulfonyl)-1,2,3,4-tetrahydroquinolin-7-yl)benzenesulfonamide, ETHANOL, GLYCEROL, ... | Authors: | Wu, X, Li, C, Zhang, Y, Xu, Y. | Deposit date: | 2022-05-07 | Release date: | 2023-05-31 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.57 Å) | Cite: | Crystal Structure of human RORgamma LBD in complex with compound XY039 To Be Published
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2C2N
| Structure of human mitochondrial malonyltransferase | Descriptor: | 1,2-DIMETHOXYETHANE, 2-(2-ETHOXYETHOXY)ETHANOL, 3,6,9,12,15-PENTAOXAHEPTADECAN-1-OL, ... | Authors: | Wu, X, Bunkoczi, G, Smee, C, Arrowsmith, C, Sundstrom, M, Weigelt, J, Edwards, A, von Delft, F, Oppermann, U. | Deposit date: | 2005-09-29 | Release date: | 2006-01-18 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural Basis for Different Specificities of Acyltransferases Associated with the Human Cytosolic and Mitochondrial Fatty Acid Synthases. Chem.Biol., 16, 2009
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2BEL
| Structure of human 11-beta-hydroxysteroid dehydrogenase in complex with NADP and carbenoxolone | Descriptor: | CARBENOXOLONE, CHLORIDE ION, CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, ... | Authors: | Kavanagh, K, Wu, X, Svensson, S, Elleby, B, von Delft, F, Debreczeni, J.E, Sharma, S, Bray, J, Edwards, A, Arrowsmith, C, Sundstrom, M, Abrahmsen, L, Oppermann, U. | Deposit date: | 2004-11-25 | Release date: | 2004-12-06 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | The High Resolution Structures of Human, Murine and Guinea Pig 11-Beta-Hydroxysteroid Dehydrogenase Type 1 Reveal Critical Differences in Active Site Architecture To be Published
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3TPX
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3TNM
| Crystal structure of A32 Fab, an ADCC mediating anti-HIV-1 antibody | Descriptor: | ACETATE ION, CHLORIDE ION, Fab heavy chain of human anti-HIV-1 Env antibody A32, ... | Authors: | Wu, X, Pazgier, M. | Deposit date: | 2011-09-01 | Release date: | 2012-09-26 | Last modified: | 2021-04-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding. Proc.Natl.Acad.Sci.USA, 110, 2013
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4DU0
| Crystal structure of human alpha-defensin 1, HNP1 (G17A mutant) | Descriptor: | CHLORIDE ION, GLYCEROL, Neutrophil defensin 1 | Authors: | Wu, X, Lu, W, Pazgier, M. | Deposit date: | 2012-02-21 | Release date: | 2012-04-11 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Invariant gly residue is important for alpha-defensin folding, dimerization, and function: a case study of the human neutrophil alpha-defensin HNP1 J.Biol.Chem., 287, 2012
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1ZY6
| Membrane-bound dimer structure of Protegrin-1 (PG-1), a beta-Hairpin Antimicrobial Peptide in Lipid Bilayers from Rotational-Echo Double-Resonance Solid-State NMR | Descriptor: | Protegrin 1 | Authors: | Wu, X, Mani, R, Tang, M, Buffy, J.J, Waring, A.J, Sherman, M.A, Hong, M. | Deposit date: | 2005-06-09 | Release date: | 2006-06-13 | Last modified: | 2022-03-02 | Method: | SOLID-STATE NMR | Cite: | Membrane-Bound Dimer Structure of a beta-Hairpin Antimicrobial Peptide from Rotational-Echo Double-Resonance Solid-State NMR. Biochemistry, 45, 2006
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4E86
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3TNN
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5DSE
| Crystal Structure of the TTC7B/Hyccin Complex | Descriptor: | Hyccin, Tetratricopeptide repeat protein 7B | Authors: | Wu, X, Baskin, J.M, Reinisch, K.M, De Camilli, P. | Deposit date: | 2015-09-17 | Release date: | 2015-12-02 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane. Nat.Cell Biol., 18, 2016
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4W60
| The structure of Vaccina virus H7 protein displays A Novel Phosphoinositide binding fold required for membrane biogenesis | Descriptor: | Late protein H7 | Authors: | Kolli, S, Meng, X, Wu, X, Shengjuler, D, Cameron, C.E, Xiang, Y, Deng, J. | Deposit date: | 2014-08-19 | Release date: | 2014-12-31 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure-function analysis of vaccinia virus h7 protein reveals a novel phosphoinositide binding fold essential for poxvirus replication. J.Virol., 89, 2015
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4V0G
| JAK3 in complex with a covalent EGFR inhibitor | Descriptor: | N-[3-(2-{3-amino-6-[1-(1-methylpiperidin-4-yl)-1H-pyrazol-4-yl]pyrazin-2-yl}-1H-benzimidazol-1-yl)phenyl]propanamide, TYROSINE-PROTEIN KINASE JAK3 | Authors: | Debreczeni, J.E, Hennessy, E.J, Chuaquini, C, Ashton, S, Coclough, N, Cross, D.A.E, Eberlein, C, Gingipalli, L, Klinowska, T.C.M, Orme, J.P, Sha, L, Wu, X. | Deposit date: | 2014-09-16 | Release date: | 2016-01-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Utilisation of Structure Based Design to Identify Novel, Irreversible Inhibitors of the Epidermal Growth Factor Receptor (Egfr) Harboring the Gatekeeper T790M Mutation To be Published
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8WY3
| Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 21 | Descriptor: | Bromodomain-containing protein 4, ~{N}-cyclopropyl-2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]ethanamide | Authors: | Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. | Deposit date: | 2023-10-30 | Release date: | 2024-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.78 Å) | Cite: | Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
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8WY7
| Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 22 | Descriptor: | 2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]-~{N}-(4-oxidanylcyclohexyl)ethanamide, Bromodomain-containing protein 4 | Authors: | Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. | Deposit date: | 2023-10-30 | Release date: | 2024-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.83 Å) | Cite: | Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
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8WXY
| Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor 23 | Descriptor: | 5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-4-[(2-morpholin-4-yl-2-oxidanylidene-ethyl)amino]pyridin-2-one, Bromodomain-containing protein 4, GLYCEROL | Authors: | Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. | Deposit date: | 2023-10-30 | Release date: | 2024-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.87 Å) | Cite: | Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
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8WYG
| Crystal Structure of the second bromodomain of human BRD2 in complex with the inhibitor 22 | Descriptor: | 2-[[5-[2-(4-fluoranyl-2,6-dimethyl-phenoxy)-5-(2-oxidanylpropan-2-yl)phenyl]-1-methyl-2-oxidanylidene-pyridin-4-yl]amino]-~{N}-(4-oxidanylcyclohexyl)ethanamide, Bromodomain-containing protein 2 | Authors: | Xu, H, Zhao, X, Shen, H, Xu, Y, Wu, X. | Deposit date: | 2023-10-30 | Release date: | 2024-01-24 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (3.13 Å) | Cite: | Discovery of Novel Phenoxyaryl Pyridones as Bromodomain and Extra-Terminal Domain (BET) Inhibitors with High Selectivity for the Second Bromodomain (BD2) to Potentially Treat Acute Myeloid Leukemia. J.Med.Chem., 67, 2024
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3QA8
| Crystal Structure of inhibitor of kappa B kinase beta | Descriptor: | MGC80376 protein | Authors: | Xu, G, Lo, Y.C, Li, Q, Napolitano, G, Wu, X, Jiang, X, Dreano, M, Karin, M, Wu, H. | Deposit date: | 2011-01-10 | Release date: | 2011-04-06 | Last modified: | 2023-07-26 | Method: | X-RAY DIFFRACTION (3.6 Å) | Cite: | Crystal structure of inhibitor of kappa B kinase beta. Nature, 472, 2011
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3RZF
| Crystal Structure of Inhibitor of kappaB kinase beta (I4122) | Descriptor: | (4-{[4-(4-chlorophenyl)pyrimidin-2-yl]amino}phenyl)[4-(2-hydroxyethyl)piperazin-1-yl]methanone, MGC80376 protein | Authors: | Xu, G, Lo, Y.C, Li, Q, Napolitano, G, Wu, X, Jiang, X, Dreano, M, Karin, M, Wu, H. | Deposit date: | 2011-05-11 | Release date: | 2011-05-25 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (4 Å) | Cite: | Crystal structure of inhibitor of KappaB kinase Beta. Nature, 472, 2011
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6PLM
| Legionella pneumophila SidJ/ Calmodulin 2 complex | Descriptor: | ADENOSINE MONOPHOSPHATE, CALCIUM ION, Calmodulin-2, ... | Authors: | Mao, Y, Sulpizio, A, Minelli, M.E, Wu, X. | Deposit date: | 2019-07-01 | Release date: | 2019-11-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (2.592 Å) | Cite: | Protein polyglutamylation catalyzed by the bacterial calmodulin-dependent pseudokinase SidJ. Elife, 8, 2019
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8TNL
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