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3TPX

Crystal structure of human MDM2 in complex with a trifluoromethylated D-peptide inhibitor

Summary for 3TPX
Entry DOI10.2210/pdb3tpx/pdb
Related3EQS 3IUX 3IWY 3LNJ 3LNZ
Related PRD IDPRD_000995
DescriptorE3 ubiquitin-protein ligase Mdm2, D-peptide inhibitor DPMI-delta, SULFATE ION, ... (6 entities in total)
Functional Keywordsligase-ligase inhibitor complex, mdm2-d-peptide inhibitor complex, p53-binding domain of mdm2-d-peptide inhibitor complex, ligase/ligase inhibitor
Biological sourceHomo sapiens (human)
Cellular locationNucleus, nucleoplasm: Q00987
Total number of polymer chains6
Total formula weight35578.48
Authors
Wu, X.,Pazgier, M. (deposition date: 2011-09-08, release date: 2012-06-20, Last modification date: 2023-12-06)
Primary citationZhan, C.,Zhao, L.,Wei, X.,Wu, X.,Chen, X.,Yuan, W.,Lu, W.Y.,Pazgier, M.,Lu, W.
An Ultrahigh Affinity d-Peptide Antagonist Of MDM2.
J.Med.Chem., 55:6237-6241, 2012
Cited by
PubMed: 22694121
DOI: 10.1021/jm3005465
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.8 Å)
Structure validation

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