3TPX

Crystal structure of human MDM2 in complex with a trifluoromethylated D-peptide inhibitor

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
C	0005634	cellular_component	nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0051726	biological_process	regulation of cell cycle
E	0005634	cellular_component	nucleus
E	0043066	biological_process	negative regulation of apoptotic process
E	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	6
Details	BINDING SITE FOR RESIDUE SO4 A 201

Chain	Residue
A	HIS73
A	GLY87
A	ARG105
A	HOH310
A	HOH358
A	HOH374

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site_id	AC2
Number of Residues	4
Details	BINDING SITE FOR RESIDUE SO4 C 201

Chain	Residue
E	ARG97
C	ASN79
C	HOH328
E	LYS51

---

site_id	AC3
Number of Residues	3
Details	BINDING SITE FOR RESIDUE SO4 C 202

Chain	Residue
A	LYS64
A	ARG97
C	LYS51

---

site_id	AC4
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL C 203

Chain	Residue
C	HIS73

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site_id	AC5
Number of Residues	7
Details	BINDING SITE FOR RESIDUE CL C 204

Chain	Residue
B	DAR12
B	HOH103
C	GLU95
C	HIS96
C	ARG97
C	LYS98
C	HOH327

---

site_id	AC6
Number of Residues	3
Details	BINDING SITE FOR RESIDUE ACT C 205

Chain	Residue
A	LYS51
B	DLY9
C	ARG97

---

site_id	AC7
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 206

Chain	Residue
C	PHE55
C	HOH307
C	HOH343
D	DSG6

---

site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT C 207

Chain	Residue
C	LYS31
C	PRO32
C	LEU33
C	HOH331

---

site_id	AC9
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 201

Chain	Residue
E	LYS98

---

site_id	BC1
Number of Residues	5
Details	BINDING SITE FOR RESIDUE CL E 202

Chain	Residue
E	GLN71
E	GLN72
E	HIS73
E	CL203
E	HOH346

---

site_id	BC2
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL E 203

Chain	Residue
E	CL202

---

site_id	BC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE ACT E 204

Chain	Residue
E	LYS31
E	PRO32
E	LEU33
E	HOH318

---

site_id	BC4
Number of Residues	28
Details	BINDING SITE FOR CHAIN B OF D-PEPTIDE INHIBITOR DPMI-DELTA

Chain	Residue
A	LYS51
A	LEU54
A	PHE55
A	LEU57
A	GLY58
A	ILE61
A	MET62
A	TYR67
A	GLN72
A	HIS73
A	PHE91
A	VAL93
A	LYS94
A	HIS96
A	ILE99
A	TYR100
B	HOH101
B	HOH102
B	HOH103
B	HOH106
B	HOH107
B	HOH108
C	LYS94
C	GLU95
C	HIS96
C	ARG97
C	CL204
C	ACT205

---

site_id	BC5
Number of Residues	26
Details	BINDING SITE FOR CHAIN D OF D-PEPTIDE INHIBITOR DPMI-DELTA

Chain	Residue
A	SER78
A	ASN79
A	ASP84
A	LYS94
A	HIS96
A	ARG97
C	LEU54
C	PHE55
C	LEU57
C	ILE61
C	MET62
C	TYR67
C	GLN72
C	HIS73
C	PHE91
C	VAL93
C	LYS94
C	HIS96
C	ILE99
C	TYR100
C	ACT206
D	HOH101
D	HOH102
D	HOH104
D	HOH105
D	HOH107

---

site_id	BC6
Number of Residues	31
Details	BINDING SITE FOR CHAIN F OF D-PEPTIDE INHIBITOR DPMI-DELTA

Chain	Residue
C	ASP80
C	LEU81
C	ASP84
E	LEU54
E	PHE55
E	LEU57
E	GLY58
E	ILE61
E	MET62
E	TYR67
E	GLN72
E	HIS73
E	PHE91
E	VAL93
E	LYS94
E	LYS94
E	GLU95
E	HIS96
E	HIS96
E	ARG97
E	ILE99
E	TYR100
E	HOH302
E	HOH306
F	HOH101
F	HOH102
F	HOH103
F	HOH105
F	HOH106
C	SER78
C	ASN79

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