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Structure of SAD kinase
Descriptor:	1,2-ETHANEDIOL, Serine/threonine-protein kinase BRSK2
Authors:	Wu, J.X, Wang, J, Chen, L, Wang, Z.X, Wu, J.W.
Deposit date:	2015-03-12
Release date:	2015-12-16
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.49 Å)
Cite:	Structural insight into the mechanism of synergistic autoinhibition of SAD kinases Nat Commun, 6, 2015

4YNZ

Structure of the N-terminal domain of SAD
Descriptor:	Serine/threonine-protein kinase BRSK2
Authors:	Wu, J.X, Wang, J, Chen, L, Wang, Z.X, Wu, J.W.
Deposit date:	2015-03-11
Release date:	2015-12-16
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Structural insight into the mechanism of synergistic autoinhibition of SAD kinases Nat Commun, 6, 2015

8XB3

Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter
Descriptor:	1-[(3-iodanylphenyl)methyl]guanidine, 2-acetamido-2-deoxy-beta-D-glucopyranose, GFP-MBP-solute carrier family 6 member 2
Authors:	Ji, W.M, Wu, J.X.
Deposit date:	2023-12-05
Release date:	2024-06-26
Method:	ELECTRON MICROSCOPY (2.8 Å)
Cite:	Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter To Be Published

8XB4

Structure of apo state of the human Norepinephrine Transporter
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, GFP-MBP-solute carrier family 6 member 2
Authors:	Wu, J.X, Ji, W.M.
Deposit date:	2023-12-05
Release date:	2024-06-26
Method:	ELECTRON MICROSCOPY (2.92 Å)
Cite:	Structural mechanism of substrate binding and inhibition of the human Norepinephrine Transporter To Be Published

8XB2

Structure of radafaxine-bound state of the human Norepinephrine Transporter
Descriptor:	(2~{S},3~{S})-2-(3-chlorophenyl)-3,5,5-trimethyl-morpholin-2-ol, 2-acetamido-2-deoxy-beta-D-glucopyranose, GFP-MBP-solute carrier family 6 member 2,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter,Maltose/maltodextrin-binding periplasmic protein,Sodium-dependent noradrenaline transporter
Authors:	Wu, J.X, Ji, W.M.
Deposit date:	2023-12-05
Release date:	2024-07-10
Method:	ELECTRON MICROSCOPY (3.04 Å)
Cite:	Substrate binding and inhibition mechanism of norepinephrine transporter To Be Published

5YKF

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (3D class1 at 4.33A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-10-14
Release date:	2018-04-18
Last modified:	2019-11-06
Method:	ELECTRON MICROSCOPY (4.33 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YKG

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (Class2 at 4.57A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-10-14
Release date:	2018-04-18
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.57 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YKE

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on TM at 4.11A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-10-14
Release date:	2018-04-18
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.11 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YWC

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class1 at 4.3A)
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.3 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YW9

Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (class1 5.0A)
Descriptor:	ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (5 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YWB

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (CTD class2 at 5.2A)
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-30
Last modified:	2019-11-06
Method:	ELECTRON MICROSCOPY (5.2 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YW8

Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (all particles at 4.4A)
Descriptor:	ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (4.4 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YWD

Structure of pancreatic ATP-sensitive potassium channel bound with Mg-ADP (focused refinement of SUR1 ABC transporter module at 4.22A)
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ATP-binding cassette sub-family C member 8 isoform X2, MAGNESIUM ION
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (4.2 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YW7

Structure of pancreatic ATP-sensitive potassium channel bound with glibenclamide and ATPgammaS (focused refinement on SUR1 ABC transporter module at 4.4A)
Descriptor:	5-chloro-N-(2-{4-[(cyclohexylcarbamoyl)sulfamoyl]phenyl}ethyl)-2-methoxybenzamide, ATP-binding cassette sub-family C member 8 isoform X2, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (4.4 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

5YWA

Structure of pancreatic ATP-sensitive potassium channel bound with ATPgammaS (CTD class 2 at 6.1A)
Descriptor:	ATP-binding cassette sub-family C member 8 isoform X2, ATP-sensitive inward rectifier potassium channel 11, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER
Authors:	Chen, L, Wu, J.X.
Deposit date:	2017-11-29
Release date:	2018-05-02
Last modified:	2018-06-13
Method:	ELECTRON MICROSCOPY (6.1 Å)
Cite:	Ligand binding and conformational changes of SUR1 subunit in pancreatic ATP-sensitive potassium channels. Protein Cell, 9, 2018

7D3F

Cryo-EM structure of human DUOX1-DUOXA1 in high-calcium state
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Dual oxidase 1, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2020-09-19
Release date:	2020-12-09
Last modified:	2021-06-23
Method:	ELECTRON MICROSCOPY (2.3 Å)
Cite:	Structures of human dual oxidase 1 complex in low-calcium and high-calcium states. Nat Commun, 12, 2021

7D3E

Cryo-EM structure of human DUOX1-DUOXA1 in low-calcium state
Descriptor:	2-acetamido-2-deoxy-beta-D-glucopyranose, Dual oxidase 1, FLAVIN-ADENINE DINUCLEOTIDE, ...
Authors:	Chen, L, Wu, J.X.
Deposit date:	2020-09-19
Release date:	2020-12-09
Last modified:	2021-06-23
Method:	ELECTRON MICROSCOPY (2.8 Å)
Cite:	Structures of human dual oxidase 1 complex in low-calcium and high-calcium states. Nat Commun, 12, 2021

5IRI

Structure of the mouse SAD-B AIS-KA1 fragment
Descriptor:	Serine/threonine-protein kinase BRSK1
Authors:	Ma, H, Wu, J.X, Wang, J, Wu, J.W.
Deposit date:	2016-03-13
Release date:	2016-06-15
Last modified:	2023-11-08
Method:	X-RAY DIFFRACTION (2.8 Å)
Cite:	Structure and inhibition analysis of the mouse SAD-B C-terminal fragment Biosci.Biotechnol.Biochem., 2016

5Z1F

Structure of atOSCA3.1 channel
Descriptor:	CSC1-like protein ERD4
Authors:	Chen, L, Zhang, M, Kang, Y, Wu, J.X.
Deposit date:	2017-12-26
Release date:	2018-09-12
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (4.8 Å)
Cite:	Structure of the mechanosensitive OSCA channels. Nat. Struct. Mol. Biol., 25, 2018

6JPF

Structure of atOSCA1.1 channel at 3.52A
Descriptor:	Protein OSCA1
Authors:	Chen, L, Zhang, M, Kang, Y, Wu, J.X.
Deposit date:	2019-03-26
Release date:	2019-04-10
Last modified:	2024-03-27
Method:	ELECTRON MICROSCOPY (3.52 Å)
Cite:	Structure of the mechanosensitive OSCA channels. Nat. Struct. Mol. Biol., 25, 2018

8GZ3

Structure of human phagocyte NADPH oxidase in the resting state
Descriptor:	1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 2-acetamido-2-deoxy-beta-D-glucopyranose, 7D5 Fab heavy chain, ...
Authors:	Chen, L, Liu, R.
Deposit date:	2022-09-24
Release date:	2022-12-21
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Structure of human phagocyte NADPH oxidase in the resting state. Elife, 11, 2022

5WUA

Structure of a Pancreatic ATP-sensitive Potassium Channel
Descriptor:	ATP-sensitive inward rectifier potassium channel 11,superfolder GFP, SUR1
Authors:	Li, N, Wu, J.-X, Chen, L, Gao, N.
Deposit date:	2016-12-16
Release date:	2017-01-25
Method:	ELECTRON MICROSCOPY (5.6 Å)
Cite:	Structure of a Pancreatic ATP-Sensitive Potassium Channel Cell, 168, 2017

7VLT

Structure of SUR2B in complex with Mg-ATP/ADP and levcromakalim
Descriptor:	(3S,4R)-2,2-dimethyl-3-oxidanyl-4-(2-oxidanylidenepyrrolidin-1-yl)-3,4-dihydrochromene-6-carbonitrile, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:	Chen, L, Ding, D.
Deposit date:	2021-10-05
Release date:	2022-05-18
Last modified:	2024-06-19
Method:	ELECTRON MICROSCOPY (3.1 Å)
Cite:	Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022

7VLR

Structure of SUR2B in complex with Mg-ATP/ADP
Descriptor:	ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, CHOLESTEROL HEMISUCCINATE, ...
Authors:	Chen, L, Ding, D.
Deposit date:	2021-10-05
Release date:	2022-05-18
Last modified:	2024-06-19
Method:	ELECTRON MICROSCOPY (3.4 Å)
Cite:	Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022

7VLU

Structure of SUR2A in complex with Mg-ATP/ADP and P1075
Descriptor:	1-cyano-2-(2-methylbutan-2-yl)-3-pyridin-3-yl-guanidine, ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, ...
Authors:	Chen, L, Ding, D.
Deposit date:	2021-10-05
Release date:	2022-05-18
Last modified:	2024-06-19
Method:	ELECTRON MICROSCOPY (3.3 Å)
Cite:	Structural identification of vasodilator binding sites on the SUR2 subunit. Nat Commun, 13, 2022

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