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SARS-CoV-2 Beta spike in complex with three S5D2 Fabs
分子名称:	Heavy chain of S5D2 Fab, Light chain of S5D2 Fab, Spike glycoprotein
著者	Wang, Y.F, Cong, Y.
登録日	2021-12-21
公開日	2022-02-02
実験手法	ELECTRON MICROSCOPY (3.5 Å)
主引用文献	Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. Emerg Microbes Infect, 11, 2022

7WCR

RBD-1 of SARS-CoV-2 Beta spike in complex with S5D2 Fab
分子名称:	Heavy chain of S5D2 Fab, Light chain of S5D2 Fab, Spike glycoprotein
著者	Wang, Y.F, Cong, Y.
登録日	2021-12-20
公開日	2022-02-02
実験手法	ELECTRON MICROSCOPY (3.5 Å)
主引用文献	Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. Emerg Microbes Infect, 11, 2022

7WDF

SARS-CoV-2 Beta spike in complex with two S3H3 Fabs
分子名称:	Heavy chain of S3H3 Fab, Light chain of S3H3 Fab, Spike glycoprotein
著者	Wang, Y.F, Cong, Y.
登録日	2021-12-21
公開日	2022-02-02
実験手法	ELECTRON MICROSCOPY (3.9 Å)
主引用文献	Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. Emerg Microbes Infect, 11, 2022

7WD0

SARS-CoV-2 Beta spike in complex with two S5D2 Fabs
分子名称:	Heavy chain of S5D2 Fab, Light chain of S5D2 Fab, Spike glycoprotein
著者	Wang, Y.F, Cong, Y.
登録日	2021-12-20
公開日	2022-02-02
実験手法	ELECTRON MICROSCOPY (3.3 Å)
主引用文献	Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. Emerg Microbes Infect, 11, 2022

7WCZ

SARS-CoV-2 Beta spike in complex with one S5D2 Fab
分子名称:	Heavy chain of S5D2 Fab, Light chain of S5D2 Fab, Spike glycoprotein
著者	Wang, Y.F, Cong, Y.
登録日	2021-12-20
公開日	2022-02-02
実験手法	ELECTRON MICROSCOPY (3.5 Å)
主引用文献	Mapping cross-variant neutralizing sites on the SARS-CoV-2 spike protein. Emerg Microbes Infect, 11, 2022

5B7J

Structure model of Sap1-DNA complex
分子名称:	DNA (5'-D(APAPTPAPTPTPGPTPTPTPTPG)-3'), DNA (5'-D(CPAPAPAPAPCPAPAPTPAPTPT)-3'), Switch-activating protein 1
著者	Jin, C, Hu, Y, Ding, J, Zhang, Y.
登録日	2016-06-07
公開日	2017-02-22
最終更新日	2024-05-01
実験手法	SOLUTION NMR
主引用文献	Sap1 is a replication-initiation factor essential for the assembly of pre-replicative complex in the fission yeast Schizosaccharomyces pombe J. Biol. Chem., 292, 2017

5DJ4

Leucine-bound Sestrin2 from Homo sapiens
分子名称:	LEUCINE, Sestrin-2
著者	Saxton, R.A, Knockenhauer, K.E, Schwartz, T.U.
登録日	2015-09-01
公開日	2015-11-25
最終更新日	2024-03-06
実験手法	X-RAY DIFFRACTION (2.697 Å)
主引用文献	Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway. Science, 351, 2016

4NCM

Influenza polymerase basic protein 2 (PB2) bound to a small-molecule inhibitor
分子名称:	N~2~-[2-(5-chloro-1H-pyrrolo[2,3-b]pyridin-3-yl)-5-fluoropyrimidin-4-yl]-N,N-dimethyl-L-alaninamide, Polymerase basic protein 2
著者	Jacobs, M.D.
登録日	2013-10-24
公開日	2014-07-30
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.82 Å)
主引用文献	Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2. J.Med.Chem., 57, 2014

4NCE

Influenza polymerase basic protein 2 (PB2) bound to 7-methyl-GTP
分子名称:	7N-METHYL-8-HYDROGUANOSINE-5'-TRIPHOSPHATE, 9,10-dioxo-9,10-dihydroanthracene-2,6-disulfonic acid, Polymerase basic protein 2
著者	Jacobs, M.D.
登録日	2013-10-24
公開日	2014-07-30
最終更新日	2023-09-20
実験手法	X-RAY DIFFRACTION (2.3 Å)
主引用文献	Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2. J.Med.Chem., 57, 2014

4IBG

Ebola virus VP35 bound to small molecule
分子名称:	GLYCEROL, PHOSPHATE ION, Polymerase cofactor VP35, ...
著者	Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
登録日	2012-12-08
公開日	2014-03-19
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.413 Å)
主引用文献	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014

4IBD

Ebola virus VP35 bound to small molecule
分子名称:	5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-methylbenzoic acid, GLYCEROL, MAGNESIUM ION, ...
著者	Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
登録日	2012-12-08
公開日	2014-03-19
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.84 Å)
主引用文献	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014

4IBB

Ebola virus VP35 bound to small molecule
分子名称:	Polymerase cofactor VP35, {4-[(5R)-3-hydroxy-2-oxo-4-(thiophen-2-ylcarbonyl)-5-(2,4,5-trimethylphenyl)-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid
著者	Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日	2012-12-08
公開日	2014-02-26
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.752 Å)
主引用文献	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014

4IBI

Ebola virus VP35 bound to small molecule
分子名称:	3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-4-hydroxy-5-oxo-3-[3-(trifluoromethyl)benzoyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, Polymerase cofactor VP35
著者	Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
登録日	2012-12-08
公開日	2014-03-19
最終更新日	2023-11-29
実験手法	X-RAY DIFFRACTION (1.473 Å)
主引用文献	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014

4IBF

Ebola virus VP35 bound to small molecule
分子名称:	(4-{(2R)-2-(4-bromothiophen-2-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}phenyl)acetic acid, Polymerase cofactor VP35
著者	Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日	2012-12-08
公開日	2014-03-19
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.291 Å)
主引用文献	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014

4IBJ

Ebola virus VP35 bound to small molecule
分子名称:	3-{(5S)-3-hydroxy-2-oxo-4-[3-(trifluoromethyl)benzoyl]-5-[3-(trifluoromethyl)phenyl]-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, Polymerase cofactor VP35
著者	Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
登録日	2012-12-08
公開日	2014-03-19
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.54 Å)
主引用文献	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014

4IBE

Ebola virus VP35 bound to small molecule
分子名称:	5-[(2R)-3-benzoyl-2-(4-bromothiophen-2-yl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]-2-chlorobenzoic acid, GLYCEROL, Polymerase cofactor VP35
著者	Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K, Center for Structural Genomics of Infectious Diseases (CSGID)
登録日	2012-12-08
公開日	2014-03-19
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.95 Å)
主引用文献	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014

4IBK

Ebola virus VP35 bound to small molecule
分子名称:	3-{(2S)-2-(7-chloro-1,3-benzodioxol-5-yl)-3-[(5-chlorothiophen-2-yl)carbonyl]-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl}benzoic acid, DIMETHYL SULFOXIDE, GLYCEROL, ...
著者	Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
登録日	2012-12-08
公開日	2014-03-19
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.85 Å)
主引用文献	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014

4IBC

Ebola virus VP35 bound to small molecule
分子名称:	DIMETHYL SULFOXIDE, Polymerase cofactor VP35, {4-[(2R)-3-(2-chlorobenzoyl)-2-(2-chlorophenyl)-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrol-1-yl]phenyl}acetic acid
著者	Brown, C.S, Leung, D.W, Xu, W, Borek, D.M, Otwinowski, Z, Ramanan, P, Stubbs, A.J, Peterson, D.S, Binning, J.M, Amarasinghe, G.K.
登録日	2012-12-08
公開日	2014-03-19
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (1.745 Å)
主引用文献	In Silico Derived Small Molecules Bind the Filovirus VP35 Protein and Inhibit Its Polymerase Cofactor Activity. J.Mol.Biol., 426, 2014

4P1U

Influenza A (flu) virus polymerase basic protein 2 (PB2) bound to VX787, an azaindole inhibitor
分子名称:	(2S,3S)-3-[[5-fluoranyl-2-(5-fluoranyl-1H-pyrrolo[2,3-b]pyridin-3-yl)pyrimidin-4-yl]amino]bicyclo[2.2.2]octane-2-carboxylic acid, Polymerase basic protein 2
著者	Jacobs, M.D.
登録日	2014-02-27
公開日	2014-07-30
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.52 Å)
主引用文献	Discovery of a Novel, First-in-Class, Orally Bioavailable Azaindole Inhibitor (VX-787) of Influenza PB2. J.Med.Chem., 57, 2014

4P6J

Crystal Structure of the Computationally Designed Transmembrane Metallotransporter with 4-bromophenylalanine in Octyl Glucoside
分子名称:	Computationally Designed Transporter of Zn(II) and Proton, SULFATE ION
著者	Joh, N.H, Acharya, R, DeGrado, W.F.
登録日	2014-03-25
公開日	2014-12-24
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.8 Å)
主引用文献	De novo design of a transmembrane Zn2+-transporting four-helix bundle. Science, 346, 2014

4P6K

Crystal Structure of the Computationally Designed Transmembrane Metallotransporter with 4-bromophenylalanine in Lipidic Cubic Phase
分子名称:	Computationally Designed Transporter of Zn(II) and Proton
著者	Joh, N.H, Acharya, R, DeGrado, W.F.
登録日	2014-03-25
公開日	2014-12-24
最終更新日	2024-03-27
実験手法	X-RAY DIFFRACTION (2.704 Å)
主引用文献	De novo design of a transmembrane Zn2+-transporting four-helix bundle. Science, 346, 2014

4PS7

Structure of PI3K gamma in complex with N-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide
分子名称:	N-[6-(pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者	Griffith, J.P.
登録日	2014-03-06
公開日	2014-05-14
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.69 Å)
主引用文献	Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase gamma. J.Med.Chem., 58, 2015

6ISU

Crystal structure of Lys27-linked di-ubiquitin in complex with its selective interacting protein UCHL3
分子名称:	Ubiquitin, Ubiquitin carboxyl-terminal hydrolase isozyme L3
著者	Ding, S, Pan, M, Zheng, Q, Ren, Y, Hong, D.
登録日	2018-11-19
公開日	2019-02-06
最終更新日	2023-11-22
実験手法	X-RAY DIFFRACTION (1.866 Å)
主引用文献	Chemical Protein Synthesis Enabled Mechanistic Studies on the Molecular Recognition of K27-linked Ubiquitin Chains. Angew. Chem. Int. Ed. Engl., 58, 2019

4PS3

Structure of PI3K gamma in complex with 1-[6-(5-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1H-imidazol-4-yl)ethyl]urea
分子名称:	1-[6-(5-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1H-imidazol-4-yl)ethyl]urea, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者	Griffith, J.P.
登録日	2014-03-06
公開日	2014-05-14
最終更新日	2024-02-28
実験手法	X-RAY DIFFRACTION (2.9 Å)
主引用文献	Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase gamma. J.Med.Chem., 58, 2015

4P6L

Crystal Structure of the Computationally Designed Transmembrane Metallotransporter in Octyl Glucoside
分子名称:	Computationally Designed Transporter of Zn(II) and proton
著者	Joh, N.H, Acharya, R, DeGrado, W.F.
登録日	2014-03-25
公開日	2014-12-24
最終更新日	2023-12-27
実験手法	X-RAY DIFFRACTION (2.803 Å)
主引用文献	De novo design of a transmembrane Zn2+-transporting four-helix bundle. Science, 346, 2014

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表示件数:	25
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