4PS3

Structure of PI3K gamma in complex with 1-[6-(5-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1H-imidazol-4-yl)ethyl]urea

Summary for 4PS3

Entry DOI	10.2210/pdb4ps3/pdb
Related	4PS7 4PS8
Descriptor	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, 1-[6-(5-methoxypyridin-3-yl)-1,3-benzothiazol-2-yl]-3-[2-(1-propyl-1H-imidazol-4-yl)ethyl]urea (3 entities in total)
Functional Keywords	serine/threonine protein kinase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm : P48736
Total number of polymer chains	1
Total formula weight	111192.69
Authors	Griffith, J.P. (deposition date: 2014-03-06, release date: 2014-05-14, Last modification date: 2024-02-28)
Primary citation	Collier, P.N.,Martinez-Botella, G.,Cornebise, M.,Cottrell, K.M.,Doran, J.D.,Griffith, J.P.,Mahajan, S.,Maltais, F.,Moody, C.S.,Huck, E.P.,Wang, T.,Aronov, A.M. Structural Basis for Isoform Selectivity in a Class of Benzothiazole Inhibitors of Phosphoinositide 3-Kinase gamma. J.Med.Chem., 58:517-521, 2015 Cited by PubMed: 24754609 DOI: 10.1021/jm500362j PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.9 Å)

Structure validation