8ESI
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![BU of 8esi by Molmil](/molmil-images/mine/8esi) | Bile Salt Hydrolase from B. longum with covalent inhibitor bound | Descriptor: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Conjugated bile acid hydrolase | Authors: | Walker, M.E, Lim, L, Redinbo, M.R. | Deposit date: | 2022-10-14 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
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8ETF
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![BU of 8etf by Molmil](/molmil-images/mine/8etf) | Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound | Descriptor: | (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Choloylglycine hydrolase, NICKEL (II) ION | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-17 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
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8ESG
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![BU of 8esg by Molmil](/molmil-images/mine/8esg) | Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound | Descriptor: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Choloylglycine hydrolase | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-14 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.18 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
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8ETK
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![BU of 8etk by Molmil](/molmil-images/mine/8etk) | Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe | Descriptor: | (5R)-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-9a,11a-dimethyl-7-(2-{2-[(prop-2-yn-1-yl)oxy]ethoxy}ethoxy)hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-1-fluorohexan-2-one (non-preferred name), Conjugated bile salt hydrolase, SODIUM ION | Authors: | Walker, M.E, Grundy, M.K, Redinbo, M.R. | Deposit date: | 2022-10-17 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
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8ETE
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![BU of 8ete by Molmil](/molmil-images/mine/8ete) | Bile Salt Hydrolase from B. longum with covalent inhibitor bound | Descriptor: | (5R)-1-fluoro-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-7-hydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]hexan-2-one (non-preferred name), Conjugated bile acid hydrolase | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-17 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
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8ESL
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![BU of 8esl by Molmil](/molmil-images/mine/8esl) | Bile Salt Hydrolase from a Bacteroidales species with covalent inhibitor bound | Descriptor: | (1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-1-[(2R)-6-fluoro-5-oxohexan-2-yl]-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-7-yl hydrogen sulfate (non-preferred name), Choloylglycine hydrolase | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-14 | Release date: | 2023-11-01 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
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8EWT
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![BU of 8ewt by Molmil](/molmil-images/mine/8ewt) | Bile salt hydrolase A from Lactobacillus gasseri bound to covalent probe | Descriptor: | (5R)-5-{(1R,3aS,3bR,5aR,7R,9aS,9bS,11aR)-9a,11a-dimethyl-7-[(prop-2-yn-1-yl)oxy]hexadecahydro-1H-cyclopenta[a]phenanthren-1-yl}-1-fluorohexan-2-one (non-preferred name), Conjugated bile salt hydrolase, SODIUM ION | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-10-24 | Release date: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.03 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
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7SVE
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![BU of 7sve by Molmil](/molmil-images/mine/7sve) | |
7SVK
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![BU of 7svk by Molmil](/molmil-images/mine/7svk) | |
7SVF
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![BU of 7svf by Molmil](/molmil-images/mine/7svf) | |
7SVH
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![BU of 7svh by Molmil](/molmil-images/mine/7svh) | Bile Salt Hydrolase B from Lactobacillus gasseri | Descriptor: | Choloylglycine hydrolase, MAGNESIUM ION | Authors: | Walker, M.E, Redinbo, M.R. | Deposit date: | 2021-11-19 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.56 Å) | Cite: | Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut. Nat Microbiol, 8, 2023
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7SVG
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![BU of 7svg by Molmil](/molmil-images/mine/7svg) | |
7SVI
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![BU of 7svi by Molmil](/molmil-images/mine/7svi) | |
7SVJ
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![BU of 7svj by Molmil](/molmil-images/mine/7svj) | Bile Salt Hydrolase from Lactobacillus ingluviei | Descriptor: | CALCIUM ION, Choloylglycine hydrolase, DI(HYDROXYETHYL)ETHER, ... | Authors: | Walker, M.E, Patel, S, Redinbo, M.R. | Deposit date: | 2021-11-19 | Release date: | 2023-01-25 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.43 Å) | Cite: | Bile salt hydrolases shape the bile acid landscape and restrict Clostridioides difficile growth in the murine gut. Nat Microbiol, 8, 2023
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7KGZ
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![BU of 7kgz by Molmil](/molmil-images/mine/7kgz) | |
8FAO
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![BU of 8fao by Molmil](/molmil-images/mine/8fao) | Bile Salt Hydrolase B from Lactobacillus gasseri with covalent inhibitor bound | Descriptor: | (5R)-5-[(1R,3aS,3bR,5aR,7R,9aS,9bS,11S,11aR)-7,11-dihydroxy-9a,11a-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-1-yl]-1-fluorohexan-2-one (non-preferred name), Choloylglycine hydrolase, NICKEL (II) ION | Authors: | Grundy, M.K, Walker, M.E, Redinbo, M.R. | Deposit date: | 2022-11-28 | Release date: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.14 Å) | Cite: | Structural diversity of bile salt hydrolases reveals rationale for substrate selectivity To Be Published
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8GET
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![BU of 8get by Molmil](/molmil-images/mine/8get) | R. hominis 2 beta-glucuronidase bound to norquetiapine-glucuronide | Descriptor: | 11-(4-beta-D-glucopyranuronosylpiperazin-1-yl)dibenzo[b,f][1,4]thiazepine, FLAVIN MONONUCLEOTIDE, GLYCEROL, ... | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-03-20 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 2024
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8GEO
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![BU of 8geo by Molmil](/molmil-images/mine/8geo) | E. eligens beta-glucuronidase bound to 3-OH-desloratidine-glucuronide | Descriptor: | 8-chloro-11-(1-beta-D-glucopyranuronosylpiperidin-4-ylidene)-3-hydroxy-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Beta-glucuronidase, GLYCEROL | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2023-03-07 | Release date: | 2024-03-20 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.89 Å) | Cite: | Gut microbial beta-glucuronidases influence endobiotic homeostasis and are modulated by diverse therapeutics. Cell Host Microbe, 2024
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8GER
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![BU of 8ger by Molmil](/molmil-images/mine/8ger) | |
7KGY
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![BU of 7kgy by Molmil](/molmil-images/mine/7kgy) | Beta-glucuronidase from Faecalibacterium prausnitzii bound to the inhibitor UNC10201652-glucuronide | Descriptor: | 8-(4-beta-D-glucopyranuronosylpiperazin-1-yl)-5-(morpholin-4-yl)-1,2,3,4-tetrahydro[1,2,3]triazino[4',5':4,5]thieno[2,3 -c]isoquinoline, Beta-glucuronidase, GLYCEROL | Authors: | Simpson, J.B, Redinbo, M.R. | Deposit date: | 2020-10-19 | Release date: | 2021-11-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Microbial enzymes induce colitis by reactivating triclosan in the mouse gastrointestinal tract. Nat Commun, 13, 2022
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