7ZIR
| Cryo-EM structure of hnRNPDL amyloid fibrils | 分子名称: | Heterogeneous nuclear ribonucleoprotein D-like | 著者 | Garcia-Pardo, J, Chaves-Sanjuan, A, Bartolome-Nafria, A, Gil-Garcia, M, Visentin, C, Bolognesi, M, Ricagno, S, Ventura, S. | 登録日 | 2022-04-08 | 公開日 | 2022-12-28 | 最終更新日 | 2023-12-13 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. Nat Commun, 14, 2023
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8BQ3
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6RO9
| Human spectrin SH3 domain D48G, E7V, K60V | 分子名称: | Spectrin alpha, non-erythrocytic 1 | 著者 | Reverter, D, Navarro, S, Ventura, S. | 登録日 | 2019-05-10 | 公開日 | 2020-06-03 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.814 Å) | 主引用文献 | Human spectrin SH3 domain D48G, E7V, K60V To Be Published
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1H20
| Solution structure of the potato carboxypeptidase inhibitor | 分子名称: | METALLOCARBOXYPEPTIDASE INHIBITOR | 著者 | Gonzalez, C, Neira, J.L, Ventura, S, Bronsoms, S, Aviles, F.X, Rico, M. | 登録日 | 2002-07-29 | 公開日 | 2003-05-09 | 最終更新日 | 2011-12-28 | 実験手法 | SOLUTION NMR | 主引用文献 | Structure and Dynamics of the Potato Carboxypeptidase Inhibitor by 1H and 15N NMR. Proteins, 50, 2003
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2V77
| Crystal Structure of Human Carboxypeptidase A1 | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CARBOXYPEPTIDASE A1, OCTANE-1,3,5,7-TETRACARBOXYLIC ACID, ... | 著者 | Pallares, I, Fernandez, D, Comellas-Bigler, M, Fernandez-Recio, J, Ventura, S, Aviles, F.X, Vendrell, J. | 登録日 | 2007-07-27 | 公開日 | 2008-07-01 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.603 Å) | 主引用文献 | Direct interaction between a human digestive protease and the mucoadhesive poly(acrylic acid). Acta Crystallogr. D Biol. Crystallogr., D64, 2008
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6TXW
| V30G Transthyretin structure in complex with Tolcalpone | 分子名称: | Tolcapone, Transthyretin | 著者 | Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. | 登録日 | 2020-01-14 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.153 Å) | 主引用文献 | Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
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6TXV
| A25T Transthyretin structure in complex with Tolcalpone | 分子名称: | Tolcapone, Transthyretin | 著者 | Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. | 登録日 | 2020-01-14 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
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6XTK
| Y114C Transthyretin structure in complex with Tolcalpone | 分子名称: | Tolcapone, Transthyretin | 著者 | Varejao, N, Reverter, D, Pinheiro, F, Pallares, I, Ventura, S. | 登録日 | 2020-01-16 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Tolcapone, a potent aggregation inhibitor for the treatment of familial leptomeningeal amyloidosis. Febs J., 288, 2021
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5A6I
| V122I Transthyretin structure in complex with Tolcalpone | 分子名称: | TRANSTHYRETIN, Tolcapone | 著者 | Reverter, D, Gallego, P, Santana, R, Ventura, S. | 登録日 | 2015-06-26 | 公開日 | 2016-02-24 | 最終更新日 | 2017-08-23 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity Nat.Commun., 7, 2016
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5AEK
| Crystal structure of the human SENP2 C548S in complex with the human SUMO1 K48M F66W | 分子名称: | SENTRIN-SPECIFIC PROTEASE 2, SMALL UBIQUITIN-RELATED MODIFIER 1 | 著者 | Gallego, P, Grana-Montes, R, Espargaro, A, Castillo, V, Torrent, J, Lange, R, Papaleo, E, Lindorff-Larsend, K, Ventura, S, Reverter, D. | 登録日 | 2014-12-23 | 公開日 | 2016-01-20 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Stepping Back and Forward on Sumo Folding Evolution To be Published
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2ABZ
| Crystal structure of C19A/C43A mutant of leech carboxypeptidase inhibitor in complex with bovine carboxypeptidase A | 分子名称: | Carboxypeptidase A1, Metallocarboxypeptidase inhibitor, ZINC ION | 著者 | Arolas, J.L, Popowicz, G.M, Bronsoms, S, Aviles, F.X, Huber, R, Holak, T.A, Ventura, S. | 登録日 | 2005-07-18 | 公開日 | 2006-01-31 | 最終更新日 | 2021-11-10 | 実験手法 | X-RAY DIFFRACTION (2.16 Å) | 主引用文献 | Study of a major intermediate in the oxidative folding of leech carboxypeptidase inhibitor: contribution of the fourth disulfide bond J.Mol.Biol., 352, 2005
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1ZFL
| Solution structure of III-A, the major intermediate in the oxidative folding of leech carboxypeptidase inhibitor | 分子名称: | Metallocarboxypeptidase inhibitor | 著者 | Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S. | 登録日 | 2005-04-20 | 公開日 | 2005-09-13 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor STRUCTURE, 13, 2005
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7QC5
| Crystal structure of human wild type transthyretin in complex with (3,4-dihydroxy-5-nitrophenyl)-(3-fluoro-5-hydroxyphenyl)methanone compound | 分子名称: | (3-fluoranyl-5-oxidanyl-phenyl)-[3-nitro-4,5-bis(oxidanyl)phenyl]methanone, Transthyretin | 著者 | Varejao, N, Pinheiro, F, Pallares, I, Ventura, S, Reverter, D. | 登録日 | 2021-11-22 | 公開日 | 2022-11-30 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Development of a Highly Potent Transthyretin Amyloidogenesis Inhibitor: Design, Synthesis, and Evaluation. J.Med.Chem., 65, 2022
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2BOA
| Human procarboxypeptidase A4. | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CARBOXYPEPTIDASE A4, ... | 著者 | Garcia-Castellanos, R, Bonet-Figueredo, R, Pallares, I, Ventura, S, Aviles, F.X, Vendrell, J, Gomis-Ruth, F.X. | 登録日 | 2005-04-08 | 公開日 | 2005-12-13 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Detailed Molecular Comparison between the Inhibition Mode of A/B-Type Carboxypeptidases in the Zymogen State and by the Endogenous Inhibitor Latexin. Cell.Mol.Life Sci., 62, 2005
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4D7B
| Structure of human transthyretin in complex with Tolcapone | 分子名称: | TRANSTHYRETIN, Tolcapone | 著者 | Gallego, P, Sant'anna, R.O, Ventura, S, Reverter, D. | 登録日 | 2014-11-21 | 公開日 | 2016-01-20 | 最終更新日 | 2016-03-02 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Repositioning Tolcapone as a Potent Inhibitor of Transthyretin Amyloidogenesis and its Associated Cellular Toxicity Nat.Commun., 7, 2016
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5FWB
| Human Spectrin SH3 domain D48G, E7F, K60F | 分子名称: | SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1 | 著者 | Gallego, P, Navarro, S, Ventura, S, Reverter, D. | 登録日 | 2016-02-12 | 公開日 | 2016-12-28 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | Human Spectrin SH3 Domain D48G, E7F, K60F To be Published
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5FW9
| Human Spectrin SH3 domain D48G, E7Y, K60Y | 分子名称: | SPECTRIN ALPHA CHAIN, NON-ERYTHROCYTIC 1 | 著者 | Gallego, P, Navarro, S, Ventura, S, Reverter, D. | 登録日 | 2016-02-12 | 公開日 | 2016-12-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Human Spectrin SH3 Domain D48G, E7Y, K60Y To be Published
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5FWC
| Human Spectrin SH3 domain D48G, E7A, K60A | 分子名称: | 1,2-ETHANEDIOL, AMMONIUM ION, SPECTRIN ALPHA CHAIN, ... | 著者 | Gallego, P, Navarro, S, Ventura, S, Reverter, D. | 登録日 | 2016-02-12 | 公開日 | 2016-12-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Human Spectrin SH3 Domain D48G, E7A, K60A To be Published
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5FW6
| Structure of human transthyretin mutant A108V | 分子名称: | TRANSTHYRETIN | 著者 | Gallego, P, Varejao, N, Santanna, R, Saraiva, M.J, Ventura, S, Reverter, D. | 登録日 | 2016-02-12 | 公開日 | 2017-03-08 | 最終更新日 | 2017-06-14 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation. Sci Rep, 7, 2017
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5FO2
| Structure of human transthyretin mutant A108I | 分子名称: | TRANSTHYRETIN | 著者 | Varejao, N, Santanna, R, Saraiva, M.J, Gallego, P, Ventura, S, Reverter, D. | 登録日 | 2015-11-17 | 公開日 | 2016-11-30 | 最終更新日 | 2017-08-23 | 実験手法 | X-RAY DIFFRACTION (1.449 Å) | 主引用文献 | Cavity filling mutations at the thyroxine-binding site dramatically increase transthyretin stability and prevent its aggregation. Sci Rep, 7, 2017
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6FWW
| GFP/KKK. A redesigned GFP with improved solubility | 分子名称: | Green fluorescent protein | 著者 | Varejao, N, Lascorz, J, Gil-Garcia, M, Diaz-Caballero, M, Navarro, S, Ventura, S, Reverter, D. | 登録日 | 2018-03-07 | 公開日 | 2018-08-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.131 Å) | 主引用文献 | Combining Structural Aggregation Propensity and Stability Predictions To Redesign Protein Solubility. Mol. Pharm., 15, 2018
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1ZFI
| Solution structure of the leech carboxypeptidase inhibitor | 分子名称: | Metallocarboxypeptidase inhibitor | 著者 | Arolas, J.L, D'Silva, L, Popowicz, G.M, Aviles, F.X, Holak, T.A, Ventura, S. | 登録日 | 2005-04-20 | 公開日 | 2005-09-13 | 最終更新日 | 2022-03-02 | 実験手法 | SOLUTION NMR | 主引用文献 | NMR structural characterization and computational predictions of the major intermediate in oxidative folding of leech carboxypeptidase inhibitor STRUCTURE, 13, 2005
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2BO9
| Human carboxypeptidase A4 in complex with human latexin. | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETONE, ... | 著者 | Pallares, I, Bonet, R, Garcia-Castellanos, R, Ventura, S, Aviles, F.X, Vendrell, J, Gomis-Rueth, F.X. | 登録日 | 2005-04-08 | 公開日 | 2005-04-15 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure of Human Carboxypeptidase A4 with its Endogenous Protein Inhibitor, Latexin. Proc.Natl.Acad.Sci.USA, 102, 2005
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5AQ0
| The structure of the Transthyretin-like domain of the first catalytic domain of the HUMAN Carboxypeptidase D | 分子名称: | CARBOXYPEPTIDASE D, GLYCEROL | 著者 | Gallego, P, Garcia-Pardo, J, Lorenzo, J, Aviles, F.X, Ventura, S, Reverter, D. | 登録日 | 2015-09-18 | 公開日 | 2016-09-28 | 実験手法 | X-RAY DIFFRACTION (0.95 Å) | 主引用文献 | The Structure of the Ttldomain of the Human Carboxypeptidase D To be Published
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6FXU
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