6FXU

Crystal structure of human transthyretin mutant T119M at pH 5.5

Summary for 6FXU

• Entry DOI: 10.2210/pdb6fxu/pdb
• Descriptor: Transthyretin (2 entities in total)
• Functional Keywords: amyloid, gatekeeper, aggregation, stability, transport protein
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 27614.90

Authors

Varejao, N.,Esperante, S.,Ventura, S.,Reverter, D. (deposition date: 2018-03-09, release date: 2019-03-20, Last modification date: 2024-02-07)

• Primary citation: Esperante, S.A.,Varejao, N.,Pinheiro, F.,Sant'Anna, R.,Luque-Ortega, J.R.,Alfonso, C.,Sora, V.,Papaleo, E.,Rivas, G.,Reverter, D.,Ventura, S.; Disease-associated mutations impacting BC-loop flexibility trigger long-range transthyretin tetramer destabilization and aggregation.; J.Biol.Chem., 297:101039-101039, 2021; PubMed: 34343569; DOI: 10.1016/j.jbc.2021.101039

Experimental method

X-RAY DIFFRACTION (1.359 Å)