4E3T
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4GY1
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4GY0
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5EH9
| Indirect contributions of mutations underlie optimization of new enzyme function | 分子名称: | 2-HYDROXYETHYL DISULFIDE, GLYCEROL, N-acyl homoserine lactonase AiiA, ... | 著者 | Hong, N.-S, Jackson, C.J, Tokuriki, N, Yang, G, Baier, F. | 登録日 | 2015-10-28 | 公開日 | 2016-09-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | Conformational Tinkering Drives Evolution of a Promiscuous Activity through Indirect Mutational Effects. Biochemistry, 55, 2016
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3A3W
| Structure of OpdA mutant (G60A/A80V/S92A/R118Q/K185R/Q206P/D208G/I260T/G273S) with diethyl 4-methoxyphenyl phosphate bound in the active site | 分子名称: | COBALT (II) ION, DIETHYL 4-METHOXYPHENYL PHOSPHATE, Phosphotriesterase | 著者 | Ollis, D.L, Tawfik, D.S, Schenk, G, Jackson, C.J, Foo, J.L, Tokuriki, N, Afriat, L, Carr, P.D, Kim, H.K. | 登録日 | 2009-06-23 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase Proc.Natl.Acad.Sci.USA, 2009
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6C2C
| The molecular basis for the functional evolution of an organophosphate hydrolysing enzyme | 分子名称: | DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ZINC ION, ... | 著者 | Hong, N.-S, Jackson, C.J, Carr, P.D, Tokuriki, N, Baier, F, Yang, G. | 登録日 | 2018-01-08 | 公開日 | 2019-01-16 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.597 Å) | 主引用文献 | Higher-order epistasis shapes the fitness landscape of a xenobiotic-degrading enzyme. Nat.Chem.Biol., 15, 2019
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3A3X
| Structure of OpdA mutant (G60A/A80V/R118Q/K185R/Q206P/D208G/I260T/G273S) | 分子名称: | COBALT (II) ION, Phosphotriesterase | 著者 | Ollis, D.L, Tawfik, D.S, Schenk, G, Jackson, C.J, Foo, J.L, Tokuriki, N, Afriat, L, Carr, P.D, Kim, H.K. | 登録日 | 2009-06-23 | 公開日 | 2010-01-12 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Conformational sampling, catalysis, and evolution of the bacterial phosphotriesterase Proc.Natl.Acad.Sci.USA, 2009
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4XAY
| Cycles of destabilization and repair underlie evolutionary transitions in enzymes | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R8, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-16 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XAZ
| Cycles of destabilization and repair underlie evolutionary transitions in enzymes | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Phosphotriesterase variant PTE-R18, ZINC ION | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-16 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XD4
| Phosphotriesterase variant E2b | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R3, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-19 | 公開日 | 2015-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XAG
| Cycles of destabilization and repair underlie the evolution of new enzyme function | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R6, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-14 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XD3
| Phosphotriesterase variant E3 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-E1, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-19 | 公開日 | 2015-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XD6
| Phosphotriesterase Variant E2a | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-E2, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-19 | 公開日 | 2015-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XD5
| Phosphotriesterase variant R2 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R2, ... | 著者 | Campbell, E, Kaltenbach, M, Tokuriki, N, Jackson, C.J. | 登録日 | 2014-12-19 | 公開日 | 2015-12-23 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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4XAF
| Cycles of destabilization and repair underlie evolutionary transitions in enzymes | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-R1, ... | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-12-14 | 公開日 | 2015-12-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat.Chem.Biol., 12, 2016
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5AJ9
| G7 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, ARYLSULFATASE, CALCIUM ION, ... | 著者 | Miton, C.M, Fischer, G, Jonas, S, Mohammed, M.F, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | 登録日 | 2015-02-20 | 公開日 | 2016-03-16 | 最終更新日 | 2019-04-24 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4PBE
| Phosphotriesterase Variant Rev6 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-revR6, ... | 著者 | Campbell, E, Kaltenbach, M, Tokuriki, N, Jackson, C.J. | 登録日 | 2014-04-12 | 公開日 | 2015-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.51 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat. Chem. Biol., 12, 2016
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4PBF
| Phosphotriesterase variant Rev12 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, CACODYLATE ION, Phosphotriesterase variant PTE-revR12, ... | 著者 | Campbell, E, Kaltenbach, M, Tokuriki, N, Jackson, C.J. | 登録日 | 2014-04-12 | 公開日 | 2015-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat. Chem. Biol., 12, 2016
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4PCN
| Phosphotriesterase variant R22 | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, Phosphotriesterase variant PTE-R22, ZINC ION | 著者 | Jackson, C.J, Campbell, E, Kaltenbach, M, Tokuriki, N. | 登録日 | 2014-04-16 | 公開日 | 2015-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat. Chem. Biol., 12, 2016
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4PCP
| Crystal structure of Phosphotriesterase variant R0 | 分子名称: | CACODYLATE ION, Phosphotriesterase variant PTE-R0, ZINC ION | 著者 | Campbell, E, Kaltenbach, M, Tokuriki, N, Jackson, C.J. | 登録日 | 2014-04-16 | 公開日 | 2015-05-06 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | The role of protein dynamics in the evolution of new enzyme function. Nat. Chem. Biol., 12, 2016
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4CYR
| G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | 分子名称: | ARYLSULFATASE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | 登録日 | 2014-04-14 | 公開日 | 2015-04-29 | 最終更新日 | 2019-07-10 | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4CYS
| G6 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with Phenylphosphonic acid | 分子名称: | AMMONIUM ION, ARYLSULFATASE, CALCIUM ION, ... | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | 登録日 | 2014-04-14 | 公開日 | 2015-04-29 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.88 Å) | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4CXS
| G4 mutant of PAS, arylsulfatase from Pseudomonas aeruginosa, in complex with Phenylphosphonic acid | 分子名称: | ARYLSULFATASE, CALCIUM ION, SULFATE ION, ... | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | 登録日 | 2014-04-08 | 公開日 | 2015-05-13 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4CXU
| G4 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa, in complex with 3-Br-Phenolphenylphosphonate | 分子名称: | 3-bromophenyl hydrogen (S)-phenylphosphonate, ARYLSULFATASE, CALCIUM ION | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | 登録日 | 2014-04-08 | 公開日 | 2015-04-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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4CXK
| G9 mutant of PAS, arylsulfatase from Pseudomonas Aeruginosa | 分子名称: | ARYLSULFATASE, CALCIUM ION, DI(HYDROXYETHYL)ETHER, ... | 著者 | Miton, C.M, Jonas, S, Mohammed, M.F, Fischer, G, Loo, B.v, Kintses, B, Hyvonen, M, Tokuriki, N, Hollfelder, F. | 登録日 | 2014-04-07 | 公開日 | 2015-04-22 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Evolutionary repurposing of a sulfatase: A new Michaelis complex leads to efficient transition state charge offset. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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