4XAY

Cycles of destabilization and repair underlie evolutionary transitions in enzymes

Summary for 4XAY

• Entry DOI: 10.2210/pdb4xay/pdb
• Related: 4PBE 4PBF 4PCN 4PCP 4XAF 4XAG 4XAZ 4XD3 4XD4 4XD5 4XD6
• Descriptor: Phosphotriesterase variant PTE-R8, ZINC ION, (4S)-2-METHYL-2,4-PENTANEDIOL, ... (5 entities in total)
• Functional Keywords: dynamics, evolution, phosphotriesterase, hydrolase
• Biological source: Brevundimonas diminuta
• Total number of polymer chains: 2
• Total formula weight: 72615.21

Authors

Jackson, C.J.,Campbell, E.,Kaltenbach, M.,Tokuriki, N. (deposition date: 2014-12-16, release date: 2015-12-16, Last modification date: 2023-11-15)

• Primary citation: Campbell, E.,Kaltenbach, M.,Correy, G.J.,Carr, P.D.,Porebski, B.T.,Livingstone, E.K.,Afriat-Jurnou, L.,Buckle, A.M.,Weik, M.,Hollfelder, F.,Tokuriki, N.,Jackson, C.J.; The role of protein dynamics in the evolution of new enzyme function.; Nat.Chem.Biol., 12:944-950, 2016; PubMed: 27618189; DOI: 10.1038/nchembio.2175

Experimental method

X-RAY DIFFRACTION (1.84 Å)