2NPU
| The solution structure of the rapamycin-binding domain of mTOR (FRB) | 分子名称: | FKBP12-rapamycin complex-associated protein | 著者 | Veverka, V, Crabbe, T, Bird, I, Lennie, G, Muskett, F.W, Taylor, R.J, Carr, M.D. | 登録日 | 2006-10-30 | 公開日 | 2007-09-18 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural characterization of the interaction of mTOR with phosphatidic acid and a novel class of inhibitor: compelling evidence for a central role of the FRB domain in small molecule-mediated regulation of mTOR. Oncogene, 27, 2008
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2KH2
| Solution structure of a scFv-IL-1B complex | 分子名称: | Interleukin-1 beta, scFv | 著者 | Wilkinson, I.C, Hall, C.J, Veverka, V, Muskett, F.W, Stephens, P.E, Taylor, R.J, Henry, A.J, Carr, M.D. | 登録日 | 2009-03-23 | 公開日 | 2009-09-08 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | High resolution NMR-based model for the structure of a scFv-IL-1beta complex: potential for NMR as a key tool in therapeutic antibody design and development. J.Biol.Chem., 284, 2009
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2K8P
| Characterisation of the structural features and interactions of sclerostin: molecular insight into a key regulator of Wnt-mediated bone formation | 分子名称: | Sclerostin | 著者 | Veverka, V, Henry, A.J, Slocombe, P.M, Ventom, A, Mulloy, B, Muskett, F.W, Muzylak, M, Greenslade, K, Moore, A, Zhang, L, Gong, J, Qian, X, Paszty, C, Taylor, R.J, Robinson, M.K, Carr, M.D. | 登録日 | 2008-09-18 | 公開日 | 2009-02-17 | 最終更新日 | 2022-03-16 | 実験手法 | SOLUTION NMR | 主引用文献 | Characterization of the Structural Features and Interactions of Sclerostin: Molecular insight into a key regulator of Wnt-mediated bone formation J.Biol.Chem., 284, 2009
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2L3Y
| Solution structure of mouse IL-6 | 分子名称: | Interleukin-6 | 著者 | Veverka, V, Redpath, N.T, Carrington, B, Muskett, F.W, Taylor, R.J, Henry, A.J, Carr, M.D. | 登録日 | 2010-09-25 | 公開日 | 2011-09-28 | 最終更新日 | 2013-01-02 | 実験手法 | SOLUTION NMR | 主引用文献 | Conservation of functional sites on interleukin-6 and implications for evolution of signaling complex assembly and therapeutic intervention. J.Biol.Chem., 287, 2012
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1RD4
| An allosteric inhibitor of LFA-1 bound to its I-domain | 分子名称: | 1-ACETYL-4-(4-{4-[(2-ETHOXYPHENYL)THIO]-3-NITROPHENYL}PYRIDIN-2-YL)PIPERAZINE, Integrin alpha-L | 著者 | Crump, M.P, Ceska, T.A, Spyracopoulos, L, Henry, A, Archibald, S.C, Alexander, R, Taylor, R.J, Findlow, S.C, O'Connell, J, Robinson, M.K, Shock, A. | 登録日 | 2003-11-05 | 公開日 | 2004-03-30 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure of an allosteric inhibitor of LFA-1 bound to the I-domain studied by crystallography, NMR, and calorimetry Biochemistry, 43, 2004
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5O57
| Solution Structure of the N-terminal Region of Dkk4 | 分子名称: | Dickkopf-related protein 4 | 著者 | Waters, L.C, Patel, S, Barkell, A.M, Muskett, F.W, Robinson, M.K, Holdsworth, G, Carr, M.D. | 登録日 | 2017-06-01 | 公開日 | 2018-06-13 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | Structural and functional analysis of Dickkopf 4 (Dkk4): New insights into Dkk evolution and regulation of Wnt signaling by Dkk and Kremen proteins. J. Biol. Chem., 293, 2018
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6MJP
| LptB(E163Q)FGC from Vibrio cholerae | 分子名称: | 2-(2-ETHOXYETHOXY)ETHANOL, 6-cyclohexylhexyl beta-D-glucopyranoside, ABC transporter ATP-binding protein, ... | 著者 | Owens, T.W, Kahne, D, Kruse, A.C. | 登録日 | 2018-09-21 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | 主引用文献 | Structural basis of unidirectional export of lipopolysaccharide to the cell surface. Nature, 567, 2019
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6MIT
| LptBFGC from Enterobacter cloacae | 分子名称: | CHLORIDE ION, LPS export ABC transporter permease LptF, Lipopolysaccharide export system ATP-binding protein, ... | 著者 | Owens, T.W, Kahne, D, Kruse, A.C. | 登録日 | 2018-09-20 | 公開日 | 2019-03-27 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Structural basis of unidirectional export of lipopolysaccharide to the cell surface. Nature, 567, 2019
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7PQC
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7PQP
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6Z3X
| Crystal structure of the designed antibody DesAb-anti-HSA-P1 | 分子名称: | CACODYLATE ION, DesAb-anti-HSA-P1, IMIDAZOLE, ... | 著者 | Costanzi, E, Sormanni, P, Ricagno, S. | 登録日 | 2020-05-22 | 公開日 | 2021-03-31 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | Fragment-based computational design of antibodies targeting structured epitopes. Sci Adv, 8, 2022
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7OUB
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8CDG
| Crystal structure of human IL-17A cytokine in complex with macrocycle | 分子名称: | (9~{S},12~{R},19~{S})-9-[[4-[[(2~{S})-2-cyclohexyl-2-(2-phenylethanoylamino)ethanoyl]amino]phenyl]methyl]-12-methyl-7,10,13,21-tetrakis(oxidanylidene)-8,11,14,20-tetrazaspiro[4.17]docosane-19-carboxylic acid, Interleukin-17A | 著者 | Schulze, M.-S. | 登録日 | 2023-01-30 | 公開日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Modulation of IL-17 backbone dynamics reduces receptor affinity and reveals a new inhibitory mechanism. Chem Sci, 14, 2023
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