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1A3W
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BU of 1a3w by Molmil
PYRUVATE KINASE FROM SACCHAROMYCES CEREVISIAE COMPLEXED WITH FBP, PG, MN2+ AND K+
分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, 2-PHOSPHOGLYCOLIC ACID, MANGANESE (II) ION, ...
著者Jurica, M.S, Mesecar, A, Heath, P.J, Shi, W, Nowak, T, Stoddard, B.L.
登録日1998-01-26
公開日1998-05-27
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献The allosteric regulation of pyruvate kinase by fructose-1,6-bisphosphate.
Structure, 6, 1998
1B0A
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BU of 1b0a by Molmil
5,10, METHYLENE-TETRAHYDROPHOLATE DEHYDROGENASE/CYCLOHYDROLASE FROM E COLI.
分子名称: PROTEIN (FOLD BIFUNCTIONAL PROTEIN)
著者Shen, B.W, Dyer, D, Huang, J.-Y, D'Ari, L, Rabinowitz, J, Stoddard, B.L.
登録日1998-11-06
公開日1999-06-29
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.56 Å)
主引用文献The crystal structure of a bacterial, bifunctional 5,10 methylene-tetrahydrofolate dehydrogenase/cyclohydrolase.
Protein Sci., 8, 1999
1BP7
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BU of 1bp7 by Molmil
GROUP I MOBILE INTRON ENDONUCLEASE I-CREI COMPLEXED WITH HOMING SITE DNA
分子名称: CALCIUM ION, DNA (5'-D(*CP*GP*AP*AP*AP*CP*TP*GP*TP*CP*TP*CP*AP*CP*GP*AP*CP*GP*TP*TP*TP*TP* GP*C)-3'), DNA (5'-D(*GP*CP*AP*AP*AP*AP*CP*GP*TP*CP*GP*TP*GP*AP*GP*AP*CP*AP*GP*TP*TP*TP* CP*G)-3'), ...
著者Jurica, M.S, Monnat Junior, R.J, Stoddard, B.L.
登録日1998-08-13
公開日1999-01-06
最終更新日2023-08-02
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献DNA recognition and cleavage by the LAGLIDADG homing endonuclease I-CreI.
Mol.Cell, 2, 1998
1CZ0
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BU of 1cz0 by Molmil
INTRON ENCODED HOMING ENDONUCLEASE I-PPOI/DNA COMPLEX LACKING CATALYTIC METAL ION
分子名称: DNA (5'-D(*TP*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*AP*GP*AP*GP*AP*GP*TP*CP*A)-3'), INTRON-ENCODED HOMING ENDONUCLEASE I-PPOI, SODIUM ION, ...
著者Galburt, E.A, Chevalier, B, Jurica, M.S, Flick, K.E, Stoddard, B.L.
登録日1999-08-31
公開日1999-11-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献A novel endonuclease mechanism directly visualized for I-PpoI.
Nat.Struct.Biol., 6, 1999
1CYQ
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BU of 1cyq by Molmil
INTRON ENCODED HOMING ENDONUCLEASE I-PPOI (H98A)/DNA HOMING SITE COMPLEX
分子名称: 5'-D(*TP*TP*GP*AP*CP*TP*CP*TP*CP*TP*TP*AP*AP*GP*AP*GP*AP*GP*TP*CP*A)-3', INTRON-ENCODED HOMING ENDONUCLEASE I-PPOI, MAGNESIUM ION, ...
著者Galburt, E.A, Chevalier, B, Jurica, M.S, Flick, K.E, Stoddard, B.L.
登録日1999-08-31
公開日1999-11-19
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献A novel endonuclease mechanism directly visualized for I-PpoI.
Nat.Struct.Biol., 6, 1999
1D7P
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BU of 1d7p by Molmil
Crystal structure of the c2 domain of human factor viii at 1.5 a resolution at 1.5 A
分子名称: COAGULATION FACTOR VIII PRECURSOR, CYSTEINE, GLYCEROL, ...
著者Pratt, K.P, Shen, B.W, Stoddard, B.L.
登録日1999-10-19
公開日1999-12-01
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structure of the C2 domain of human factor VIII at 1.5 A resolution.
Nature, 402, 1999
7JTA
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BU of 7jta by Molmil
Crystal structure of a putative nuclease with anti-Cas9 activity from an uncultured Clostridia bacterium
分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, NITRATE ION, NTF2-like nuclease/anti-CRISPR
著者Werther, R, Forsberg, K.J, Stoddard, B.L.
登録日2020-08-17
公開日2021-09-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.801 Å)
主引用文献The novel anti-CRISPR AcrIIA22 relieves DNA torsion in target plasmids and impairs SpyCas9 activity.
Plos Biol., 19, 2021
7RDR
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BU of 7rdr by Molmil
Circular tandem repeat protein with novel repeat topology and enhanced subunit contact surfaces
分子名称: Circular tendon repeat protein
著者Shen, B.W, Stoddard, B.L.
登録日2021-07-10
公開日2021-09-01
最終更新日2021-11-17
実験手法ELECTRON MICROSCOPY (6.5 Å)
主引用文献Design of functionalised circular tandem repeat proteins with longer repeat topologies and enhanced subunit contact surfaces.
Commun Biol, 4, 2021
7R9G
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BU of 7r9g by Molmil
Catalytically inactive yeast Pseudouridine Synthase, PUS1, bound to RNA
分子名称: CHLORIDE ION, RNA (5'-R(*AP*AP*AP*UP*CP*GP*GP*GP*AP*UP*UP*CP*CP*GP*GP*AP*UP*A)-3'), SULFATE ION, ...
著者Doyle, L.A, Stoddard, B.L.
登録日2021-06-29
公開日2021-12-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献The structural basis of mRNA recognition and binding by yeast pseudouridine synthase PUS1.
Plos One, 18, 2023
7R9F
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BU of 7r9f by Molmil
Wild-type yeast Pseudouridine Synthase, PUS1, bound to 5-Fluorouracil RNA
分子名称: RNA (5'-R(*UP*AP*AP*UP*CP*GP*GP*GP*AP*UP*UP*CP*CP*GP*GP*AP*UP*A)-3'), SULFATE ION, tRNA pseudouridine synthase 1
著者Doyle, L.A, Stoddard, B.L.
登録日2021-06-29
公開日2021-12-15
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.89 Å)
主引用文献The structural basis of mRNA recognition and binding by yeast pseudouridine synthase PUS1.
Plos One, 18, 2023
7RCG
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BU of 7rcg by Molmil
I-OnuI_e-hPD1-f final stage reengineered variant of I-OnuI
分子名称: CALCIUM ION, CHLORIDE ION, DNA (26-MER), ...
著者Smiley, A.T, Werther, R.A, Stoddard, B.L.
登録日2021-07-07
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.368 Å)
主引用文献Characterization of the stepwise engineering and optimization of a retargeted DNA binding protein and gene-editing meganuclease
To Be Published
7RCD
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BU of 7rcd by Molmil
Second stage reengineered variant of I-OnuI targeting human PD1 gene with activity enhancing substitutions
分子名称: CALCIUM ION, DNA (26-MER), I-OnuI_e-hPD1-c
著者Ubilla-Rodriguez, N.C, Werther, R.A, Stoddard, B.L.
登録日2021-07-07
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.448 Å)
主引用文献Characterization of the stepwise engineering and optimization of a retargeted DNA binding protein and gene-editing meganuclease
To Be Published
7RCF
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BU of 7rcf by Molmil
Fourth stage reengineered variant of I-OnuI with stability enhancing substitutions
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CHLORIDE ION, ...
著者Ubilla-Rodriguez, N.C, Werther, R.A, Stoddard, B.L.
登録日2021-07-07
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.233 Å)
主引用文献Characterization of the stepwise engineering and optimization of a retargeted DNA binding protein and gene-editing meganuclease
To Be Published
7RCE
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BU of 7rce by Molmil
Third stage reengineered variant of I-OnuI with specificity enhancing substitutions
分子名称: CALCIUM ION, DNA (26-MER), I-OnuI_e-hPD1-d, ...
著者Ubilla-Rodriguez, N.C, Werther, R.A, Stoddard, B.L.
登録日2021-07-07
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.42 Å)
主引用文献Characterization of the stepwise engineering and optimization of a retargeted DNA binding protein and gene-editing meganuclease
To Be Published
7RCC
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BU of 7rcc by Molmil
First stage engineered variant of I-OnuI after initial reassembly
分子名称: CALCIUM ION, DNA (26-MER), I-OnuI_e-hPD1-b
著者Ubilla-Rodriguez, N.C, Werther, R.A, Stoddard, B.L.
登録日2021-07-07
公開日2022-06-29
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Characterization of the stepwise engineering and optimization of a retargeted DNA binding protein and gene-editing meganuclease
To Be Published
3QQY
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BU of 3qqy by Molmil
Crystal structure of a novel LAGLIDADG homing endonuclease, I-OnuI (from Ophiostoma novo-ulmi subsp. americana)
分子名称: DNA (26-MER), MAGNESIUM ION, Ribosomal protein 3/homing endonuclease-like protein fusion
著者Takeuchi, R, Stoddard, B.L.
登録日2011-02-16
公開日2011-07-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.401 Å)
主引用文献Tapping natural reservoirs of homing endonucleases for targeted gene modification.
Proc.Natl.Acad.Sci.USA, 108, 2011
3R7P
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BU of 3r7p by Molmil
The crystal structure of I-LtrI
分子名称: DNA (5'-D(*CP*AP*AP*AP*TP*GP*CP*TP*CP*CP*TP*AP*TP*AP*C)-3'), DNA (5'-D(*GP*GP*TP*CP*TP*AP*AP*AP*CP*GP*TP*CP*GP*TP*AP*T)-3'), DNA (5'-D(P*AP*GP*GP*AP*GP*CP*AP*TP*TP*TP*G)-3'), ...
著者Mak, A.N.S, Takeuchi, R, Edgell, D.R, Stoddard, B.L.
登録日2011-03-22
公開日2011-07-20
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.704 Å)
主引用文献Tapping natural reservoirs of homing endonucleases for targeted gene modification.
Proc.Natl.Acad.Sci.USA, 108, 2011
3R3P
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BU of 3r3p by Molmil
Homing Endonuclease I-Bth0305I Catalytic Domain
分子名称: Mobile intron protein
著者Taylor, G.K, Stoddard, B.L.
登録日2011-03-16
公開日2011-10-05
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Activity, specificity and structure of I-Bth0305I: a representative of a new homing endonuclease family.
Nucleic Acids Res., 39, 2011
3S1S
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BU of 3s1s by Molmil
Characterization and crystal structure of the type IIG restriction endonuclease BpuSI
分子名称: 1,2-ETHANEDIOL, IODIDE ION, MANGANESE (II) ION, ...
著者Shen, B.W, Xu, D, Chan, S.-H, Zheng, Y, Zhu, Y, Xu, S.-Y, Stoddard, B.L.
登録日2011-05-16
公開日2011-07-13
最終更新日2011-10-19
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Characterization and crystal structure of the type IIG restriction endonuclease RM.BpuSI.
Nucleic Acids Res., 39, 2011
3T1G
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BU of 3t1g by Molmil
Engineering of organophosphate hydrolase by computational design and directed evolution
分子名称: CALCIUM ION, ZINC ION, organophosphate hydrolase
著者Takeuchi, R, Stoddard, B.L.
登録日2011-07-21
公開日2012-02-08
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Computational redesign of a mononuclear zinc metalloenzyme for organophosphate hydrolysis.
Nat.Chem.Biol., 8, 2012
3E0L
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BU of 3e0l by Molmil
Computationally Designed Ammelide Deaminase
分子名称: Guanine deaminase, ZINC ION
著者Murphy, P.M, Bolduc, J.M, Gallaher, J.L, Stoddard, B.L, Baker, D.
登録日2008-07-31
公開日2009-03-03
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.37 Å)
主引用文献Alteration of enzyme specificity by computational loop remodeling and design.
Proc.Natl.Acad.Sci.USA, 106, 2009
3EH8
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BU of 3eh8 by Molmil
Crystal structure of Y2 I-AniI variant (F13Y/S111Y)/DNA complex with calcium
分子名称: 31-MER, CALCIUM ION, Intron-encoded DNA endonuclease I-AniI
著者Takeuchi, R, Stoddard, B.L.
登録日2008-09-11
公開日2009-01-13
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Optimization of in vivo activity of a bifunctional homing endonuclease and maturase reverses evolutionary degradation.
Nucleic Acids Res., 37, 2009
3E54
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BU of 3e54 by Molmil
Archaeal Intron-encoded Homing Endonuclease I-Vdi141I Complexed With DNA
分子名称: DNA (5'-D(*DCP*DTP*DGP*DAP*DCP*DTP*DCP*DTP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(*DTP*DTP*DGP*DGP*DCP*DTP*DAP*DCP*DCP*DTP*DTP*DAP*DA)-3'), DNA (5'-D(P*DGP*DAP*DGP*DAP*DGP*DTP*DCP*DAP*DG)-3'), ...
著者Nomura, N, Nomura, Y, Sussman, D, Stoddard, B.L.
登録日2008-08-13
公開日2008-12-30
最終更新日2021-11-10
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Recognition of a common rDNA target site in archaea and eukarya by analogous LAGLIDADG and His-Cys box homing endonucleases
Nucleic Acids Res., 36, 2008
3HYJ
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BU of 3hyj by Molmil
Crystal structure of the N-terminal LAGLIDADG domain of DUF199/WhiA
分子名称: CHLORIDE ION, GLYCEROL, Protein DUF199/WhiA, ...
著者Kaiser, B.K, Clifton, M.C, Shen, B.W, Stoddard, B.L.
登録日2009-06-22
公開日2009-09-01
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease.
Structure, 17, 2009
3HYI
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BU of 3hyi by Molmil
Crystal structure of full-length DUF199/WhiA from Thermatoga maritima
分子名称: GLYCEROL, Protein DUF199/WhiA, SODIUM ION
著者Kaiser, B.K, Clifton, M.C, Shen, B.W, Stoddard, B.L.
登録日2009-06-22
公開日2009-09-01
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (2.34 Å)
主引用文献The structure of a bacterial DUF199/WhiA protein: domestication of an invasive endonuclease
Structure, 17, 2009

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