5GCH
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1IKA
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4GCH
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3SDP
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3GCH
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4Z1X
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1BL5
| ISOCITRATE DEHYDROGENASE FROM E. COLI SINGLE TURNOVER LAUE STRUCTURE OF RATE-LIMITED PRODUCT COMPLEX, 10 MSEC TIME RESOLUTION | 分子名称: | 2-OXOGLUTARIC ACID, ISOCITRATE DEHYDROGENASE, MAGNESIUM ION, ... | 著者 | Stoddard, B.L, Cohen, B, Brubaker, M, Mesecar, A, Koshland Junior, D.E. | 登録日 | 1998-07-23 | 公開日 | 1999-05-04 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Millisecond Laue structures of an enzyme-product complex using photocaged substrate analogs. Nat.Struct.Biol., 5, 1998
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2R7E
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1AI3
| ORBITAL STEERING IN THE CATALYTIC POWER OF ENZYMES: SMALL STRUCTURAL CHANGES WITH LARGE CATALYTIC CONSEQUENCES | 分子名称: | ISOCITRATE DEHYDROGENASE, ISOCITRIC ACID, MAGNESIUM ION, ... | 著者 | Stoddard, B.L, Mesecar, A, Koshland Junior, D.E. | 登録日 | 1997-04-30 | 公開日 | 1997-11-12 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences. Science, 277, 1997
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1AI2
| ISOCITRATE DEHYDROGENASE COMPLEXED WITH ISOCITRATE, NADP+, AND CALCIUM (FLASH-COOLED) | 分子名称: | ISOCITRATE CALCIUM COMPLEX, ISOCITRATE DEHYDROGENASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Stoddard, B.L, Mesecar, A, Koshland Junior, D.E. | 登録日 | 1997-04-30 | 公開日 | 1997-10-15 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Orbital steering in the catalytic power of enzymes: small structural changes with large catalytic consequences. Science, 277, 1997
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3B5L
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5IF6
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5IER
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4J9A
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5T2O
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5T2H
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5T2N
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4J8T
| Engineered Digoxigenin binder DIG10.2 | 分子名称: | DIGOXIGENIN, Engineered Digoxigenin binder protein DIG10.2 | 著者 | Stoddard, B.L, Doyle, L.A. | 登録日 | 2013-02-14 | 公開日 | 2013-06-26 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | 主引用文献 | Computational design of ligand-binding proteins with high affinity and selectivity. Nature, 501, 2013
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1P8K
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5T8D
| Engineered variant of I-OnuI meganuclease targeting the HIV integrase gene; harbors 47 point mutations relative to wild-type I-OnuI | 分子名称: | CALCIUM ION, DNA (26-MER), I-OnuI_e-vHIVInt_v2 | 著者 | Stoddard, B.L, Werther, R, Lambert, A.R. | 登録日 | 2016-09-07 | 公開日 | 2017-05-03 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Tuning DNA binding affinity and cleavage specificity of an engineered gene-targeting nuclease via surface display, flow cytometry and cellular analyses. Protein Eng.Des.Sel., 30, 2017
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3HOJ
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5JSN
| Bcl2-inhibitor complex | 分子名称: | Apoptosis regulator Bcl-2, Bcl2 inhibitor | 著者 | Shen, B.W, Stoddard, B.L. | 登録日 | 2016-05-09 | 公開日 | 2016-11-16 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer. Elife, 5, 2016
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2QOJ
| Coevolution of a homing endonuclease and its host target sequence | 分子名称: | I-AniI DNA target seq1, I-AniI DNA target seq2, LAGLIDADG endonuclease, ... | 著者 | Scalley-Kim, M, McConnell Smith, A, Stoddard, B.L. | 登録日 | 2007-07-20 | 公開日 | 2008-11-11 | 最終更新日 | 2021-10-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Coevolution of a homing endonuclease and its host target sequence. J.Mol.Biol., 372, 2007
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7RDR
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6D0T
| De novo design of a fluorescence-activating beta barrel - BB1 | 分子名称: | BB1 | 著者 | Dou, J, Vorobieva, A.A, Sheffler, W, Doyle, L.A, Park, H, Bick, M.J, Mao, B, Foight, G.W, Lee, M, Carter, L, Sankaran, B, Ovchinnikov, S, Marcos, E, Huang, P, Vaughan, J.C, Stoddard, B.L, Baker, D. | 登録日 | 2018-04-10 | 公開日 | 2018-09-19 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | De novo design of a fluorescence-activating beta-barrel. Nature, 561, 2018
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