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5JXC
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BU of 5jxc by Molmil
SynGAP Coiled-coil trimer
分子名称: Ras/Rap GTPase-activating protein SynGAP
著者Shang, Y, Zhang, M.
登録日2016-05-13
公開日2016-09-28
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.
Cell, 166, 2016
5JXB
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BU of 5jxb by Molmil
PSD-95 extended PDZ3 in complex with SynGAP PBM
分子名称: Disks large homolog 4,SynGAP
著者Shang, Y, Zhang, M.
登録日2016-05-13
公開日2016-09-28
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Phase Transition in Postsynaptic Densities Underlies Formation of Synaptic Complexes and Synaptic Plasticity.
Cell, 166, 2016
5B64
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A novel binding mode of MAGUK GK domain revealed by DLG GK domain in complex with KIF13B MBS domain
分子名称: DLG GK, GLYCEROL, Protein Kif13b, ...
著者Shang, Y, Zhu, J, Zhang, M.
登録日2016-05-24
公開日2016-10-12
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献An Atypical MAGUK GK Target Recognition Mode Revealed by the Interaction between DLG and KIF13B
Structure, 24, 2016
5GNV
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BU of 5gnv by Molmil
Structure of PSD-95/MAP1A complex reveals unique target recognition mode of MAGUK GK domain
分子名称: Disks large homolog 4, Microtubule-associated protein 1A, SULFATE ION
著者Shang, Y, Xia, Y, Zhu, R, Zhu, J.
登録日2016-07-25
公開日2017-08-02
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.596 Å)
主引用文献Structure of the PSD-95/MAP1A complex reveals a unique target recognition mode of the MAGUK GK domain
Biochem. J., 474, 2017
4G2V
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BU of 4g2v by Molmil
Structure complex of LGN binding with FRMPD1
分子名称: 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, G-protein-signaling modulator 2, ...
著者Shang, Y, Pan, Z, Wen, W, Wang, W, Zhang, M.
登録日2012-07-13
公開日2013-01-23
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structural and biochemical characterization of the interaction between LGN and Frmpd1
J.Mol.Biol., 425, 2013
4DC2
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BU of 4dc2 by Molmil
Structure of PKC in Complex with a Substrate Peptide from Par-3
分子名称: ADENINE, Partitioning defective 3 homolog, Protein kinase C iota type
著者Shang, Y, Wang, C, Yu, J, Zhang, M.
登録日2012-01-17
公開日2012-07-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Substrate recognition mechanism of atypical protein kinase Cs revealed by the structure of PKC iota in complex with a substrate peptide from Par-3
Structure, 20, 2012
4IA9
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Crystal structure of human WD REPEAT DOMAIN 5 in complex with 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide
分子名称: 1,2-ETHANEDIOL, 2-chloro-4-fluoro-3-methyl-N-[2-(4-methylpiperazin-1-yl)-5-nitrophenyl]benzamide, UNKNOWN ATOM OR ION, ...
著者Dong, A, Dombrovski, L, Bolshan, Y, Getlik, M, Tempel, W, Kuznetsova, E, Wasney, G.A, Hajian, T, Poda, G, Nguyen, K.T, Schapira, M, Brown, P.J, Al-awar, R, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Smil, D, Vedadi, M, Wu, H, Structural Genomics Consortium (SGC)
登録日2012-12-06
公開日2012-12-26
最終更新日2023-09-20
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Synthesis, Optimization, and Evaluation of Novel Small Molecules as Antagonists of WDR5-MLL Interaction.
ACS Med Chem Lett, 4, 2013
5IZU
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BU of 5izu by Molmil
A new binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function
分子名称: SH3 and multiple ankyrin repeat domains protein 3, peptide from Disks large-associated protein 3
著者Shang, Y, Zeng, M, Zhang, M.
登録日2016-03-26
公開日2016-05-18
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.494 Å)
主引用文献A binding site outside the canonical PDZ domain determines the specific interaction between Shank and SAPAP and their function
Proc.Natl.Acad.Sci.USA, 113, 2016
3RO2
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BU of 3ro2 by Molmil
Structures of the LGN/NuMA complex
分子名称: G-protein-signaling modulator 2, GLYCEROL, peptide of Nuclear mitotic apparatus protein 1
著者Shang, Y, Wei, Z.
登録日2011-04-25
公開日2012-03-07
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献LGN/mInsc and LGN/NuMA complex structures suggest distinct functions in asymmetric cell division for the Par3/mInsc/LGN and G[alpha]i/LGN/NuMA pathways
Mol.Cell, 43, 2011
7F7G
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a linear Peptide Inhibitors in complex with GK domain
分子名称: DLG4 GK domain, UNK-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYS-ALA-ILE-GLN-UNK
著者Shang, Y, Huang, X, Li, X, Zhang, M.
登録日2021-06-29
公開日2022-02-23
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.446 Å)
主引用文献Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
7F7I
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Stapled Peptide Inhibitor in complex with PSD95 GK domain
分子名称: ACE-ARG-ILE-ARG-ARG-ASP-GLU-TYR-LEU-LYZ-ALA-ILE-GLN-NH2, Disks large homolog 4
著者Shang, Y, Huang, X, Li, X, Zhang, M.
登録日2021-06-29
公開日2022-04-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.595 Å)
主引用文献Entropy of stapled peptide inhibitors in free state is the major contributor to the improvement of binding affinity with the GK domain.
Rsc Chem Biol, 2, 2021
3UAT
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BU of 3uat by Molmil
Guanylate Kinase Domains of the MAGUK Family Scaffold Proteins as Specific Phospho-Protein Binding Modules
分子名称: Disks large homolog 1, phosphor-LGN peptide
著者Shang, Y, Zhu, J, Wen, W, Zhang, M.
登録日2011-10-22
公開日2011-12-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Guanylate kinase domains of the MAGUK family scaffold proteins as specific phospho-protein-binding modules
Embo J., 2011
3KEX
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BU of 3kex by Molmil
Crystal structure of the catalytically inactive kinase domain of the human epidermal growth factor receptor 3 (HER3)
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Receptor tyrosine-protein kinase erbB-3
著者Jura, N, Shan, Y, Cao, X, Shaw, D.E, Kuriyan, J.
登録日2009-10-26
公開日2009-12-22
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (2.797 Å)
主引用文献Structural analysis of the catalytically inactive kinase domain of the human EGF receptor 3.
Proc.Natl.Acad.Sci.USA, 106, 2009
2M20
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BU of 2m20 by Molmil
EGFR transmembrane - juxtamembrane (TM-JM) segment in bicelles: MD guided NMR refined structure.
分子名称: Epidermal growth factor receptor
著者Endres, N.F, Das, R, Smith, A, Arkhipov, A, Kovacs, E, Huang, Y, Pelton, J.G, Shan, Y, Shaw, D.E, Wemmer, D.E, Groves, J.T, Kuriyan, J.
登録日2012-12-11
公開日2013-02-20
最終更新日2024-05-01
実験手法SOLUTION NMR
主引用文献Conformational Coupling across the Plasma Membrane in Activation of the EGF Receptor.
Cell(Cambridge,Mass.), 152, 2013
4F3L
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BU of 4f3l by Molmil
Crystal Structure of the Heterodimeric CLOCK:BMAL1 Transcriptional Activator Complex
分子名称: BMAL1b, Circadian locomoter output cycles protein kaput
著者Huang, N, Chelliah, Y, Shan, Y, Taylor, C, Yoo, S, Partch, C, Green, C.B, Zhang, H, Takahashi, J.
登録日2012-05-09
公開日2012-06-06
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.268 Å)
主引用文献Crystal structure of the heterodimeric CLOCK:BMAL1 transcriptional activator complex.
Science, 337, 2012
3G6G
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BU of 3g6g by Molmil
Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
分子名称: GLYCEROL, N-{3-[(3-{4-[(4-methoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]-4-methylphenyl}-4-[(4-methylpiperazin-1-yl)methyl]benzamide, Proto-oncogene tyrosine-protein kinase Src
著者Seeliger, M.A, Ranjitkar, P, Kasap, C, Shan, Y, Shaw, D.E, Shah, N.P, Kuriyan, J, Maly, D.J.
登録日2009-02-06
公開日2009-03-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.31 Å)
主引用文献Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
3G6H
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BU of 3g6h by Molmil
Src Thr338Ile inhibited in the DFG-Asp-Out conformation
分子名称: N-{4-methyl-3-[(3-{4-[(3,4,5-trimethoxyphenyl)amino]-1,3,5-triazin-2-yl}pyridin-2-yl)amino]phenyl}-3-(trifluoromethyl)benzamide, Proto-oncogene tyrosine-protein kinase Src
著者Seeliger, M.A, Ranjitkar, P, Kasap, C, Shan, Y, Shaw, D.E, Shah, N.P, Kuriyan, J, Maly, D.J.
登録日2009-02-06
公開日2009-03-24
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Equally potent inhibition of c-Src and Abl by compounds that recognize inactive kinase conformations
Cancer Res., 69, 2009
7B38
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Torpedo californica acetylcholinesterase complexed with Mg+2
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Acetylcholinesterase, ...
著者Silman, I, Shnyrov, V.L, Ashani, Y, Roth, E, Nicolas, A, Sussman, J.L, Weiner, L.
登録日2020-11-29
公開日2021-03-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Protein Sci., 30, 2021
7B8E
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Torpedo californica acetylcholinesterase complexed with Ca+2
分子名称: 1,2-ETHANEDIOL, 2-[2-(2-ethoxyethoxy)ethoxy]ethanol, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Silman, I, Shnyrov, V.L, Ashani, Y, Roth, E, Nicolas, A, Sussman, J.L.
登録日2020-12-12
公開日2021-03-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.23 Å)
主引用文献Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Protein Sci., 30, 2021
7B2W
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Torpedo californica acetylcholinesterase complexed with UO2
分子名称: Acetylcholinesterase, URANYL (VI) ION
著者Silman, I, Shnyrov, V.L, Ashani, Y, Roth, E, Nicolas, A, Sussman, J.L, Weiner, L.
登録日2020-11-28
公開日2021-03-17
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Torpedo californica acetylcholinesterase is stabilized by binding of a divalent metal ion to a novel and versatile 4D motif.
Protein Sci., 30, 2021
3WP1
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BU of 3wp1 by Molmil
Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
分子名称: Disks large homolog 4, Lethal(2) giant larvae protein homolog 2, SULFATE ION
著者Zhu, J, Shang, Y, Wan, Q, Xia, Y, Chen, J, Du, Q, Zhang, M.
登録日2014-01-08
公開日2014-03-19
最終更新日2014-04-30
実験手法X-RAY DIFFRACTION (2.804 Å)
主引用文献Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
3WP0
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BU of 3wp0 by Molmil
Crystal structure of Dlg GK in complex with a phosphor-Lgl2 peptide
分子名称: Disks large homolog 4, GLYCEROL, Lethal(2) giant larvae protein homolog 2
著者Zhu, J, Shang, Y, Wan, Q, Xia, Y, Chen, J, Du, Q, Zhang, M.
登録日2014-01-08
公開日2014-03-19
最終更新日2014-04-30
実験手法X-RAY DIFFRACTION (2.039 Å)
主引用文献Phosphorylation-dependent interaction between tumor suppressors Dlg and Lgl
Cell Res., 24, 2014
6FFW
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Phosphotriesterase PTE_A53_5
分子名称: (4~{S},6~{R})-2,2,6-trimethyl-1,3-dioxan-4-ol, 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ...
著者Dym, O, Aggarwal, N, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Leader, H, Ashani, Y, Goldsmith, M, Greisen, P, Tawfik, D, Sussman, L.J.
登録日2018-01-09
公開日2019-03-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.495 Å)
主引用文献Phosphotriesterase PTE_A53_5
To Be Published
6FQE
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Phosphotriesterase PTE_A53_4
分子名称: (4~{S},6~{R})-2,2,6-trimethyl-1,3-dioxan-4-ol, DI(HYDROXYETHYL)ETHER, FORMIC ACID, ...
著者Dym, O, Aggarwal, N, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Leader, H, Ashani, Y, Goldsmith, M, Greisen, P, Tawfik, D, Sussman, L.J.
登録日2018-02-14
公開日2019-03-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Phosphotriesterase PTE_A53_4
To Be Published
6FWE
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Phosphotriesterase PTE_C23_6
分子名称: 1-[methoxy(methyl)phosphoryl]oxyethane, 1-ethyl-1-methyl-cyclohexane, FORMIC ACID, ...
著者Dym, O, Aggarwal, N, Albeck, S, Unger, T, Hamer Rogotner, S, Silman, I, Leader, H, Ashani, Y, Goldsmith, M, Greisen, P, Tawfik, D, Sussman, L.J.
登録日2018-03-06
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.774 Å)
主引用文献Phosphotriesterase PTE_C23_6
To Be Published

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件を2024-09-18に公開中

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