4JPW
| Crystal structure of broadly and potently neutralizing antibody 12a21 in complex with hiv-1 strain 93th057 gp120 mutant | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, HEAVY CHAIN OF ANTIBODY 12A21, ... | Authors: | Acharya, P, Luongo, T, Zhou, T, Kwong, P.D. | Deposit date: | 2013-03-19 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.904 Å) | Cite: | Somatic mutations of the immunoglobulin framework are generally required for broad and potent HIV-1 neutralization. Cell(Cambridge,Mass.), 153, 2013
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4JKP
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4P9M
| Crystal structure of 8ANC195 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 8ANC195 Fab heavy chain, 8ANC195 light chain | Authors: | Scharf, L, Bjorkman, P.J. | Deposit date: | 2014-04-04 | Release date: | 2014-05-21 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Antibody 8ANC195 Reveals a Site of Broad Vulnerability on the HIV-1 Envelope Spike. Cell Rep, 7, 2014
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4JPV
| Crystal structure of broadly and potently neutralizing antibody 3bnc117 in complex with hiv-1 gp120 | Descriptor: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Zhou, T, Moquin, S, Kwong, P.D. | Deposit date: | 2013-03-19 | Release date: | 2013-04-17 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (2.827 Å) | Cite: | Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization. Cell(Cambridge,Mass.), 153, 2013
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4P9H
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4RQQ
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3TNM
| Crystal structure of A32 Fab, an ADCC mediating anti-HIV-1 antibody | Descriptor: | ACETATE ION, CHLORIDE ION, Fab heavy chain of human anti-HIV-1 Env antibody A32, ... | Authors: | Wu, X, Pazgier, M. | Deposit date: | 2011-09-01 | Release date: | 2012-09-26 | Last modified: | 2021-04-21 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Diverse specificity and effector function among human antibodies to HIV-1 envelope glycoprotein epitopes exposed by CD4 binding. Proc.Natl.Acad.Sci.USA, 110, 2013
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3U7Y
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3U7W
| Crystal structure of NIH45-46 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, Heavy chain, ... | Authors: | Diskin, R, Bjorkman, P.J. | Deposit date: | 2011-10-14 | Release date: | 2011-11-16 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Increasing the Potency and Breadth of an HIV Antibody by Using Structure-Based Rational Design. Science, 334, 2011
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4B50
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5F4U
| HIV-1 gp120 complex with BNM-IV-197 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, ~{N}'-[(1~{R},2~{R})-2-(carbamimidamidomethyl)-6-[[carbamimidoyl(methyl)amino]methyl]-2,3-dihydro-1~{H}-inden-1-yl]-~{N}-(4-chloranyl-3-fluoranyl-phenyl)ethanediamide | Authors: | Liang, S, Hendrickson, W.A. | Deposit date: | 2015-12-03 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition. ACS Med Chem Lett, 7, 2016
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5F4R
| HIV-1 gp120 complex with BNW-IV-147 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, FORMIC ACID, ... | Authors: | Liang, S, Hendrickson, W.A. | Deposit date: | 2015-12-03 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition. ACS Med Chem Lett, 7, 2016
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5F4P
| HIV-1 gp120 complex with BNM-III-170 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, ~{N}'-[(1~{R},2~{R})-2-(carbamimidamidomethyl)-5-(methylaminomethyl)-2,3-dihydro-1~{H}-inden-1-yl]-~{N}-(4-chloranyl-3-fluoranyl-phenyl)ethanediamide | Authors: | Liang, S, Hendrickson, W.A. | Deposit date: | 2015-12-03 | Release date: | 2016-03-30 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition. Acs Med.Chem.Lett., 7, 2016
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5F4L
| HIV-1 gp120 complex with JP-III-048 | Descriptor: | ENVELOPE GLYCOPROTEIN GP120 of HIV-1 clade C, ~{N}'-[(1~{R},2~{R})-2-(carbamimidamidomethyl)-6-(methylaminomethyl)-2,3-dihydro-1~{H}-inden-1-yl]-~{N}-(4-chloranyl-3-fluoranyl-phenyl)ethanediamide | Authors: | Liang, S, Hendrickson, W.A. | Deposit date: | 2015-12-03 | Release date: | 2016-03-30 | Last modified: | 2017-11-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Small-Molecule CD4-Mimics: Structure-Based Optimization of HIV-1 Entry Inhibition. Acs Med.Chem.Lett., 7, 2016
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4D9L
| Fab structure of anti-HIV-1 gp120 V2 mAb 697 | Descriptor: | Heavy chain of Fab fragment of anti-HIV1 gp120 V2 mAb 697, Light chain of Fab fragment of anti-HIV1 gp120 V2 mAb 697 | Authors: | Pan, R.M, Kong, X.P. | Deposit date: | 2012-01-11 | Release date: | 2012-03-21 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.485 Å) | Cite: | Functional and immunochemical cross-reactivity of V2-specific monoclonal antibodies from HIV-1-infected individuals. Virology, 427, 2012
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4FQ1
| Crystal Structure of PGT121 Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab heavy chain, Fab light chain | Authors: | Scharf, L, Bjorkman, P.J. | Deposit date: | 2012-06-24 | Release date: | 2012-11-14 | Last modified: | 2021-05-19 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc.Natl.Acad.Sci.USA, 109, 2012
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4FQ2
| Crystal Structure of 10-1074 Fab | Descriptor: | 1,2-ETHANEDIOL, Fab heavy chain, Fab light chain, ... | Authors: | Scharf, L, Bjorkman, P.J. | Deposit date: | 2012-06-24 | Release date: | 2012-11-14 | Last modified: | 2021-05-19 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc.Natl.Acad.Sci.USA, 109, 2012
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4FQC
| Crystal Structure of PGT121 Fab Bound to a complex-type sialylated N-glycan | Descriptor: | Fab heavy chain, Fab light chain, N-acetyl-alpha-neuraminic acid-(2-6)-beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Scharf, L, Bjorkman, P.J. | Deposit date: | 2012-06-25 | Release date: | 2012-11-14 | Last modified: | 2021-05-19 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Complex-type N-glycan recognition by potent broadly neutralizing HIV antibodies. Proc.Natl.Acad.Sci.USA, 109, 2012
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4FQQ
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4GW4
| Crystal structure of 3BNC60 Fab with P61A mutation | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 3BNC60 Fab Heavy-chain, 3BNC60 Fab Light-chain | Authors: | Diskin, R, Fu, B.Z, Bjorkman, P.J. | Deposit date: | 2012-08-31 | Release date: | 2013-04-17 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization. Cell(Cambridge,Mass.), 153, 2013
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6MNR
| Rhesus macaque anti-HIV V3 antibody DH753 with gp120 V3 ZAM18 peptide | Descriptor: | 1,2-ETHANEDIOL, Ab DH753 heavy chain Fab fragment, Ab DH753 light chain, ... | Authors: | Nicely, N.I. | Deposit date: | 2018-10-02 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.201 Å) | Cite: | Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations. Nat Commun, 10, 2019
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6MNQ
| Rhesus macaque anti-HIV V3 antibody DH727.2 with gp120 V3 ZAM18 peptide | Descriptor: | 1,2-ETHANEDIOL, Ab DH727.2 heavy chain Fab fragment, Ab DH727.2 light chain, ... | Authors: | Nicely, N.I. | Deposit date: | 2018-10-02 | Release date: | 2019-07-24 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.804 Å) | Cite: | Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations. Nat Commun, 10, 2019
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6MNS
| Rhesus macaque anti-HIV V3 antibody DH753 with gp120 V3 ZAM18 peptide | Descriptor: | Ab DH753 heavy chain Fab fragment, Ab DH753 light chain, Envelope glylcoprotein, ... | Authors: | Nicely, N.I. | Deposit date: | 2018-10-02 | Release date: | 2019-07-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Difficult-to-neutralize global HIV-1 isolates are neutralized by antibodies targeting open envelope conformations. Nat Commun, 10, 2019
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6OKQ
| Crystal structure of the SF12 Fab | Descriptor: | SF12 Fab Heavy Chain,SF12 Fab Heavy Chain, SF12 Fab Light Chain,SF12 Fab Light Chain | Authors: | Barnes, C.O, Bjorkman, P.J. | Deposit date: | 2019-04-14 | Release date: | 2019-06-05 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope. Immunity, 50, 2019
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6OKP
| B41 SOSIP.664 in complex with the silent-face antibody SF12 and V3-targeting antibody 10-1074 | Descriptor: | 10-1074 Heavy Chain,10-1074 Heavy Chain, 10-1074 Light Chain,10-1074 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Barnes, C.O, Bjorkman, P.J. | Deposit date: | 2019-04-14 | Release date: | 2019-06-05 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Broad and Potent Neutralizing Antibodies Recognize the Silent Face of the HIV Envelope. Immunity, 50, 2019
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