5XJW
| Crystal Structure of the [Co2+-(Chromomycin A3)2]-CCG repeats Complex | Descriptor: | (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-4-O-acetyl-2,6-dideoxy-beta-D-galactopyranose, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-beta-D-Olivopyranose-(1-3)-beta-D-Olivopyranose, ... | Authors: | Tseng, W.H, Wu, P.C, Satange, R.B, Hou, M.H. | Deposit date: | 2017-05-04 | Release date: | 2018-05-16 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.097 Å) | Cite: | Crystal Structure of the [Co2+-(Chromomycin A3)2]-CCG repeats Complex To be published
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6J0I
| Structure of [Co2+-(Chromomycin A3)2]-d(TTGGCGAA)2 complex | Descriptor: | 1,2-HYDRO-1-OXY-3,4-HYDRO-3-(1-METHOXY-2-OXY-3,4-DIHYDROXYPENTYL)-8,9-DIHYROXY-7-METHYLANTHRACENE, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... | Authors: | Satange, R.B, Chuang, C.Y, Hou, M.H. | Deposit date: | 2018-12-24 | Release date: | 2019-07-24 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation. Nucleic Acids Res., 47, 2019
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6J0H
| Crystal structure of Actinomycin D- d(TTGGCGAA) complex | Descriptor: | Actinomycin D, DNA (5'-D(P*TP*TP*GP*GP*CP*GP*AP*A)-3'), SODIUM ION | Authors: | Satange, R.B, Hou, M.H. | Deposit date: | 2018-12-24 | Release date: | 2019-07-24 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.52 Å) | Cite: | Polymorphic G:G mismatches act as hotspots for inducing right-handed Z DNA by DNA intercalation. Nucleic Acids Res., 47, 2019
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7DQ8
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7DQ0
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8W76
| Crystal structure of d(CGTATACG)2 duplex | Descriptor: | DNA (5'-D(P*CP*GP*TP*AP*TP*AP*CP*G)-3'), MANGANESE (II) ION | Authors: | Satange, R.B, Peng, C.L, Hou, M.H. | Deposit date: | 2023-08-30 | Release date: | 2024-08-07 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (2.71 Å) | Cite: | Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects. Nucleic Acids Res., 52, 2024
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5GUN
| Crystal structure of d(GTGGAATGGAAC) | Descriptor: | COBALT (II) ION, DNA (5'-D(*GP*TP*GP*GP*AP*AP*TP*GP*GP*AP*AP*C)-3') | Authors: | Satange, R.B, Kao, Y.F, Hou, M.H. | Deposit date: | 2016-08-29 | Release date: | 2017-08-30 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.588 Å) | Cite: | Parity-dependent hairpin configurations of repetitive DNA sequence promote slippage associated with DNA expansion Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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7BPV
| r(GUGGGCCGAC)/d(GTCGGCCCAC) hybrid duplex structure | Descriptor: | DNA (5'-D(P*GP*TP*CP*GP*GP*CP*CP*CP*AP*C)-3'), RNA (5'-R(P*GP*UP*GP*GP*GP*CP*CP*GP*AP*C)-3'), SULFATE ION | Authors: | Wang, S.C, Satange, R.B, Hou, M.H. | Deposit date: | 2020-03-23 | Release date: | 2021-03-03 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.781 Å) | Cite: | Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Nucleic Acids Res., 49, 2021
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5YZE
| Crystal structure of the [Co2+-(chromomycin A3)2]-d(CCG)3 complex | Descriptor: | (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... | Authors: | Hou, M.H, Chen, Y.W, Wu, P.C, Satange, R.B. | Deposit date: | 2017-12-14 | Release date: | 2018-10-17 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.87 Å) | Cite: | CoII(Chromomycin)2 Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex Int J Mol Sci, 19, 2018
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5ZT2
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8WQ7
| Crystal structure of d(CGTATACG)2 with a four-carbon linker containing diacridine compound | Descriptor: | DNA (5'-D(P*CP*GP*TP*AP*TP*AP*CP*G)-3'), MANGANESE (II) ION, N,N'-di(acridin-9-yl)butane-1,4-diamine | Authors: | Huang, S.C, Satange, R.B, Hou, M.H. | Deposit date: | 2023-10-11 | Release date: | 2024-08-07 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects. Nucleic Acids Res., 52, 2024
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8W7W
| Crystal structure of d(CGTATACG)2 with acridine complex | Descriptor: | DNA (5'-D(P*CP*GP*TP*AP*TP*AP*CP*G)-3'), MAGNESIUM ION, ~{N},~{N}'-di(acridin-9-yl)pentane-1,5-diamine | Authors: | Huang, S.C, Satange, R.B, Hou, M.H. | Deposit date: | 2023-08-31 | Release date: | 2024-08-07 | Last modified: | 2024-09-11 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Targeting DNA junction sites by bis-intercalators induces topological changes with potent antitumor effects. Nucleic Acids Res., 52, 2024
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6L75
| Crystal structure of d(GTGGGCCGAC)2 DNA duplex | Descriptor: | DNA (5'-D(P*GP*TP*GP*GP*GP*CP*CP*GP*AP*C)-3') | Authors: | Hou, M.H, Satange, R.B, Zeng, J.Y. | Deposit date: | 2019-10-31 | Release date: | 2021-01-13 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.578 Å) | Cite: | Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Nucleic Acids Res., 49, 2021
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6L76
| Crystal structure of the Ni(II)(Chro)2-d(TTGGGCCGAA/TTCGGCCCAA) complex at 2.94 angstrom resolution | Descriptor: | (1S)-5-deoxy-1-O-methyl-1-C-[(2R,3S)-3,5,7,10-tetrahydroxy-6-methyl-4-oxo-1,2,3,4-tetrahydroanthracen-2-yl]-D-xylulose, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, ... | Authors: | Hou, M.H, Jhan, C.R, Satange, R.B, Lin, S.M. | Deposit date: | 2019-10-31 | Release date: | 2021-01-13 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.94 Å) | Cite: | Targeting the ALS/FTD-associated A-DNA kink with anthracene-based metal complex causes DNA backbone straightening and groove contraction. Nucleic Acids Res., 49, 2021
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6M4T
| U shaped head to head four-way junction in d(TTCTGCTGCTGAA) sequence | Descriptor: | COBALT (II) ION, DNA (5'-D(P*(UD)P*TP*CP*TP*GP*CP*TP*GP*CP*TP*GP*AP*A)-3'), N4-[4-[(6-chloranyl-2-methoxy-acridin-9-yl)amino]butyl]-1,3,5-triazine-2,4,6-triamine | Authors: | Hou, M.H, Chien, C.M, Satange, R.B, Wu, P.C. | Deposit date: | 2020-03-09 | Release date: | 2020-07-15 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA. J.Am.Chem.Soc., 142, 2020
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6M5J
| U shaped head to head four-way junction in d(TTCTGCTGCTGAA/TTCTGCAGCTGAA) sequence | Descriptor: | COBALT (II) ION, DNA (5'-D(P*TP*TP*CP*TP*GP*CP*AP*GP*CP*TP*GP*AP*A)-3'), DNA (5'-D(P*TP*TP*CP*TP*GP*CP*TP*GP*CP*TP*GP*AP*A)-3'), ... | Authors: | Hou, M.H, Chien, C.M, Satange, R.B. | Deposit date: | 2020-03-11 | Release date: | 2020-07-15 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Structural Basis for Targeting T:T Mismatch with Triaminotriazine-Acridine Conjugate Induces a U-Shaped Head-to-Head Four-Way Junction in CTG Repeat DNA. J.Am.Chem.Soc., 142, 2020
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7X9F
| Crystal structure of actinomycin D-echinomycin-d(AGCGCGT/ACGCGCT) complex | Descriptor: | 2-CARBOXYQUINOXALINE, DNA (5'-D(P*AP*CP*GP*CP*GP*CP*T)-3'), DNA (5'-D(P*AP*GP*CP*GP*CP*GP*T)-3'), ... | Authors: | Kao, S.H, Satange, R.B, Hou, M.H. | Deposit date: | 2022-03-15 | Release date: | 2022-12-14 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.96 Å) | Cite: | Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50, 2022
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7X6R
| Crystal structure of actinomycin D-echinomycin-d(AGCACGT/ACGGGCT) complex | Descriptor: | 2-CARBOXYQUINOXALINE, Actinomycin D, COBALT (II) ION, ... | Authors: | Kao, S.H, Satange, R.B, Hou, M.H. | Deposit date: | 2022-03-08 | Release date: | 2022-12-14 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50, 2022
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7X97
| Crystal structure of actinomycin D-echinomycin-d(AGCCCGT/ACGGGCT) complex | Descriptor: | 2-CARBOXYQUINOXALINE, Actinomycin D, CHLORIDE ION, ... | Authors: | Kao, S.H, Satange, R.B, Hou, M.H. | Deposit date: | 2022-03-15 | Release date: | 2022-12-14 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50, 2022
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7XDJ
| Crystal structure of actinomycin D-echinomycin-d(AGCGCGT/ACGAGCT) complex | Descriptor: | 2-CARBOXYQUINOXALINE, CHLORIDE ION, DNA (5'-D(P*AP*CP*GP*AP*GP*CP*(BRU))-3'), ... | Authors: | Chien, C.M, Satange, R.B, Hou, M.H. | Deposit date: | 2022-03-27 | Release date: | 2022-12-14 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (2.435 Å) | Cite: | Staggered intercalation of DNA duplexes with base-pair modulation by two distinct drug molecules induces asymmetric backbone twisting and structure polymorphism. Nucleic Acids Res., 50, 2022
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7Y2P
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7Y2B
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