5YZE

Crystal structure of the [Co2+-(chromomycin A3)2]-d(CCG)3 complex

Summary for 5YZE

• Entry DOI: 10.2210/pdb5yze/pdb
• Descriptor: DNA (5'-D(*TP*CP*CP*GP*CP*CP*GP*CP*CP*GP*A)-3'), 3-C-methyl-4-O-acetyl-alpha-L-Olivopyranose-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol-(1-3)-(2R,5S,6R)-6-methyltetrahydro-2H-pyran-2,5-diol, 2,6-dideoxy-4-O-methyl-alpha-D-galactopyranose-(1-3)-(2R,3R,6R)-6-hydroxy-2-methyltetrahydro-2H-pyran-3-yl acetate, ... (6 entities in total)
• Functional Keywords: drug-dna complex, chromomycin a3, ccg repeats, i-motif, flipout, dna, antibiotics-dna complex, antibiotics/dna
• Biological source: synthetic construct
• Total number of polymer chains: 2
• Total formula weight: 9109.66

Authors

Hou, M.H.,Chen, Y.W.,Wu, P.C.,Satange, R.B. (deposition date: 2017-12-14, release date: 2018-10-17, Last modification date: 2024-03-27)

• Primary citation: Chen, Y.W.,Satange, R.,Wu, P.C.,Jhan, C.R.,Chang, C.K.,Chung, K.R.,Waring, M.J.,Lin, S.W.,Hsieh, L.C.,Hou, M.H.; CoII(Chromomycin)2 Complex Induces a Conformational Change of CCG Repeats from i-Motif to Base-Extruded DNA Duplex; Int J Mol Sci, 19:-, 2018; PubMed: 30227633; DOI: 10.3390/ijms19092796

Experimental method

X-RAY DIFFRACTION (1.87 Å)