7DQ0

Crystal structure of actinomycin D-echinomycin-d(ACGTGCT/AGCTCGT) complex

Summary for 7DQ0

• Entry DOI: 10.2210/pdb7dq0/pdb
• Related PRD ID: PRD_000001 PRD_000491
• Descriptor: DNA (5'-D(P*AP*GP*CP*TP*CP*GP*T)-3'), Actinomycin D, Echinomycin, ... (8 entities in total)
• Functional Keywords: drug-dna complex, dna mismatch, dna unwinding, dna deformation, dna, antibiotic-dna complex, antibiotic/dna
• Biological source: Streptomyces sp.; More
• Total number of polymer chains: 4
• Total formula weight: 6875.27

Authors

Satange, R.B.,Hou, M.H. (deposition date: 2020-12-22, release date: 2021-12-29, Last modification date: 2023-11-29)

• Primary citation: Satange, R.,Chang, C.C.,Li, L.Y.,Lin, S.H.,Neidle, S.,Hou, M.H.; Synergistic binding of actinomycin D and echinomycin to DNA mismatch sites and their combined anti-tumour effects.; Nucleic Acids Res., 2023; PubMed: 36919604; DOI: 10.1093/nar/gkad156

Experimental method

X-RAY DIFFRACTION (2 Å)