7Y2P

Crystal structure of CUG repeat RNA duplex containing A-U base pair and U-U mismatches

Summary for 7Y2P

• Entry DOI: 10.2210/pdb7y2p/pdb
• Descriptor: RNA (5'-R(P*UP*UP*CP*UP*GP*CP*UP*GP*CP*UP*GP*AP*A)-3'), RNA (5'-R(P*UP*UP*CP*UP*GP*CP*AP*GP*CP*UP*GP*AP*A)-3') (3 entities in total)
• Functional Keywords: cug repeats, myotonic dystrophy type 1 (dm1), u-u mismatches, rna, a-u base pair
• Biological source: synthetic construct; More
• Total number of polymer chains: 2
• Total formula weight: 8213.93

Authors

Wang, S.C.,Satange, R.B.,Hou, M.H. (deposition date: 2022-06-09, release date: 2023-05-31, Last modification date: 2023-11-29)

• Primary citation: Wang, S.C.,Chen, Y.T.,Satange, R.,Chu, J.W.,Hou, M.H.; Structural basis for water modulating RNA duplex formation in the CUG repeats of myotonic dystrophy type 1.; J.Biol.Chem., 299:104864-104864, 2023; PubMed: 37245780; DOI: 10.1016/j.jbc.2023.104864

Experimental method

X-RAY DIFFRACTION (1.58 Å)