4PGZ
 
 | | Structural basis of KIT activation by oncogenic mutations in the extracellular region reveals a zipper-like mechanism for ligand-dependent or oncogenic receptor tyrosine kinase activation | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, COBALT (II) ION, Mast/stem cell growth factor receptor Kit | | 著者 | Reshetnyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J. | | 登録日 | 2014-05-03 | | 公開日 | 2015-03-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | The strength and cooperativity of KIT ectodomain contacts determine normal ligand-dependent stimulation or oncogenic activation in cancer.
Mol.Cell, 57, 2015
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7MZY
 | | Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 673-986 | | 分子名称: | ACETATE ION, ALK tyrosine kinase receptor | | 著者 | Reshetnyak, A.V, Sowaileh, M, Miller, D.J, Rossi, P, Myasnikov, A.G, Kalodimos, C.G. | | 登録日 | 2021-05-24 | | 公開日 | 2021-11-24 | | 最終更新日 | 2021-12-15 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature, 600, 2021
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7N00
 | | Anaplastic lymphoma kinase (ALK) extracellular fragment of ligand binding region 648-1025 in complex with AUG-alpha | | 分子名称: | ALK and LTK ligand 2, ALK tyrosine kinase receptor | | 著者 | Reshetnyak, A.V, Myasnikov, A.G, Rossi, P, Miller, D.J, Kalodimos, C.G. | | 登録日 | 2021-05-24 | | 公開日 | 2021-11-24 | | 最終更新日 | 2021-12-15 | | 実験手法 | ELECTRON MICROSCOPY (2.27 Å) | | 主引用文献 | Mechanism for the activation of the anaplastic lymphoma kinase receptor.
Nature, 600, 2021
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7MZX
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7MZW
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7MZZ
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4K94
 | | Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibody Fab19 | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Fab19 heavy chain, Fab19 light chain, ... | | 著者 | Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J. | | 登録日 | 2013-04-19 | | 公開日 | 2013-10-16 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4K9E
 | | Crystal structure of KIT D4D5 fragment in complex with anti-Kit antibodies Fab79D | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Mast/stem cell growth factor receptor Kit, heavy chain, ... | | 著者 | Resheynyak, A.V, Boggon, T.J, Lax, I, Schlessinger, J. | | 登録日 | 2013-04-19 | | 公開日 | 2013-10-16 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural basis for KIT receptor tyrosine kinase inhibition by antibodies targeting the D4 membrane-proximal region.
Proc.Natl.Acad.Sci.USA, 110, 2013
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7MK7
 | | Augmentor domain of augmentor-beta | | 分子名称: | ALK and LTK ligand 1,Maltodextrin-binding protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | 著者 | Krimmer, S.G, Reshetnyak, A.V, Puleo, D.E, Schlessinger, J. | | 登録日 | 2021-04-21 | | 公開日 | 2021-11-24 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.42815185 Å) | | 主引用文献 | Structural basis for ligand reception by anaplastic lymphoma kinase.
Nature, 600, 2021
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