6OQM
 
 | | crystal structure of the MSH6 PWWP domain | | 分子名称: | DNA mismatch repair protein Msh6, MAGNESIUM ION, SULFATE ION, ... | | 著者 | Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | | 登録日 | 2019-04-26 | | 公開日 | 2019-05-29 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | crystal structure of the MSH6 PWWP domain
To Be Published
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4FU6
 | | Crystal structure of the PSIP1 PWWP domain | | 分子名称: | GLYCEROL, PC4 and SFRS1-interacting protein, SULFATE ION, ... | | 著者 | Qin, S, Tempel, W, Xu, C, Wu, H, Dong, A, Cerovina, T, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2012-06-28 | | 公開日 | 2012-08-29 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structure and function of the nucleosome-binding PWWP domain.
Trends Biochem.Sci., 39, 2014
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4HAE
 | | Crystal structure of the CDYL2-chromodomain | | 分子名称: | Chromodomain Y-like protein 2, SULFATE ION, UNKNOWN ATOM OR ION | | 著者 | Qin, S, Dombrovski, L, Tempel, W, Dong, A, Xu, C, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Wu, H, Structural Genomics Consortium (SGC) | | 登録日 | 2012-09-26 | | 公開日 | 2012-10-10 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structure of the CDYL2-chromodomain
To be Published
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2KU3
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2L43
 | | Structural basis for histone code recognition by BRPF2-PHD1 finger | | 分子名称: | Histone H3.3,LINKER,Bromodomain-containing protein 1, ZINC ION | | 著者 | Qin, S, Zhang, J, Wu, J, Shi, Y. | | 登録日 | 2010-10-01 | | 公開日 | 2011-08-31 | | 最終更新日 | 2020-01-15 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Recognition of unmodified histone H3 by the first PHD finger of Bromodomain-PHD finger protein 2 provides insights into the regulation of histone acetyltransferases MOZ and MORF
To be Published
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4NW2
 | | Tandem chromodomains of human CHD1 in complex with Influenza virus NS1 C-terminal tail trimethylated at K229 | | 分子名称: | Chromodomain-helicase-DNA-binding protein 1, GLYCEROL, Nonstructural protein 1, ... | | 著者 | Qin, S, Tempel, W, Xu, C, El Bakkouri, M, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2013-12-05 | | 公開日 | 2014-01-29 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Nat Commun, 5, 2014
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4O45
 | | WDR5 in complex with influenza NS1 C-terminal tail | | 分子名称: | Nonstructural protein 1, UNKNOWN ATOM OR ION, WD repeat-containing protein 5 | | 著者 | Qin, S, Xu, C, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2013-12-18 | | 公開日 | 2014-04-23 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Nat Commun, 5, 2014
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4O46
 | | 14-3-3-gamma in complex with influenza NS1 C-terminal tail phosphorylated at S228 | | 分子名称: | 14-3-3 protein gamma, Nonstructural protein 1, UNKNOWN ATOM OR ION, ... | | 著者 | Qin, S, Liu, Y, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2013-12-18 | | 公開日 | 2014-04-30 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Nat Commun, 5, 2014
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4O42
 | | Tandem chromodomains of human CHD1 in complex with influenza NS1 C-terminal tail dimethylated at K229 | | 分子名称: | Chromodomain-helicase-DNA-binding protein 1, GLYCEROL, Nonstructural protein 1, ... | | 著者 | Qin, S, Xu, C, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2013-12-18 | | 公開日 | 2014-04-16 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Structural basis for histone mimicry and hijacking of host proteins by influenza virus protein NS1.
Nat Commun, 5, 2014
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6V3N
 | | Crystal structure of CDYL2 in complex with H3K27me3 | | 分子名称: | ACE-GLN-LEU-ALA-THR-LYS-ALA-ALA-ARG-M3L-SER-ALA-PRO-ALA-THR-TYR-NH2, Chromodomain Y-like protein 2, UNKNOWN ATOM OR ION | | 著者 | Qin, S, Tempel, W, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | | 登録日 | 2019-11-26 | | 公開日 | 2020-04-01 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
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6V41
 | | crystal structure of CDY1 chromodomain bound to H3K9me3 | | 分子名称: | Histone H3.1 Peptide, Testis-specific chromodomain protein Y 1, UNKNOWN ATOM OR ION | | 著者 | Qin, S, Tempel, W, Walker, J.R, Arrowsmith, C.H, Bountra, C, Edwards, A.M, Min, J, Structural Genomics Consortium, Structural Genomics Consortium (SGC) | | 登録日 | 2019-11-27 | | 公開日 | 2019-12-25 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (1.603 Å) | | 主引用文献 | Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
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2MJ8
 | | Solution structure of CDYL2 chromodomain | | 分子名称: | Chromodomain Y-like protein 2 | | 著者 | Qin, S, Houliston, S, Arrowsmith, C.H, Edwards, A.M, Wu, H, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2013-12-28 | | 公開日 | 2014-04-23 | | 最終更新日 | 2023-06-14 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structural Basis for the Binding Selectivity of Human CDY Chromodomains.
Cell Chem Biol, 27, 2020
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6BHG
 | | Crystal structure of SETDB1 with a modified H3 peptide | | 分子名称: | Histone H3.1, Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION | | 著者 | Qin, S, Tempel, W, Dong, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2017-10-30 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | | 主引用文献 | H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
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6BHD
 | | Crystal structure of SETDB1 with a modified H3 peptide | | 分子名称: | Histone H3.1, Histone-lysine N-methyltransferase SETDB1, SODIUM ION, ... | | 著者 | Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2017-10-30 | | 公開日 | 2017-12-06 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
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6BHI
 | | Crystal structure of SETDB1 with a modified H3 peptide | | 分子名称: | Histone H3.1, Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION | | 著者 | Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2017-10-30 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
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6BHE
 | | Crystal structure of SETDB1 with a modified H3 peptide | | 分子名称: | Histone H3.1, Histone-lysine N-methyltransferase SETDB1, UNKNOWN ATOM OR ION | | 著者 | Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2017-10-30 | | 公開日 | 2017-12-06 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | | 主引用文献 | H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
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6BHH
 | | Crystal structure of SETDB1 with a modified H3 peptide | | 分子名称: | Histone H3.1, Histone-lysine N-methyltransferase SETDB1, SULFATE ION, ... | | 著者 | Qin, S, Tempel, W, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2017-10-30 | | 公開日 | 2017-11-22 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | H3K14ac is linked to methylation of H3K9 by the triple Tudor domain of SETDB1.
Nat Commun, 8, 2017
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6CKN
 | | Crystal structure of an AF10 fragment | | 分子名称: | Protein AF-10, UNKNOWN ATOM OR ION | | 著者 | Qin, S, Tempel, W, Li, Y, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Min, J, Structural Genomics Consortium (SGC) | | 登録日 | 2018-02-28 | | 公開日 | 2018-03-21 | | 最終更新日 | 2018-04-18 | | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | | 主引用文献 | Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.
Genes Dev., 32, 2018
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4TY9
 | | An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | | 分子名称: | 5-(trifluoromethyl)pyridin-2-amine, Polyprotein | | 著者 | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | | 登録日 | 2014-07-08 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
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4TYB
 | | An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | | 分子名称: | (2R)-morpholin-4-yl(phenyl)ethanenitrile, Polyprotein | | 著者 | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | | 登録日 | 2014-07-08 | | 公開日 | 2015-05-20 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.93 Å) | | 主引用文献 | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
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4TYA
 | | An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | | 分子名称: | 4-(trifluoromethyl)benzoic acid, Polyprotein | | 著者 | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | | 登録日 | 2014-07-08 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.94 Å) | | 主引用文献 | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
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4TXS
 | | An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | | 分子名称: | (4-hydroxyphenyl)acetonitrile, Polyprotein | | 著者 | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | | 登録日 | 2014-07-07 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
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4TY8
 | | An Ligand-observed Mass Spectrometry-based Approach Integrated into the Fragment Based Lead Discovery Pipeline | | 分子名称: | 6-methyl-2H-chromen-2-one, Polyprotein | | 著者 | Shui, W, Yang, C, Lin, J, Chen, X, Qin, S, Chen, S. | | 登録日 | 2014-07-08 | | 公開日 | 2015-05-06 | | 最終更新日 | 2024-03-20 | | 実験手法 | X-RAY DIFFRACTION (2.78 Å) | | 主引用文献 | A ligand-observed mass spectrometry approach integrated into the fragment based lead discovery pipeline
Sci Rep, 5, 2015
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4NS5
 | | Crystal structure of human BS69 Bromo-Zinc finger-PWWP | | 分子名称: | ZINC ION, Zinc finger MYND domain-containing protein 11 | | 著者 | Wang, J.C, Qin, S, Li, F.D, Li, S, Zhang, W, Wu, J.H, Shi, Y.Y. | | 登録日 | 2013-11-28 | | 公開日 | 2014-04-09 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of human BS69 Bromo-ZnF-PWWP reveals its role in H3K36me3 nucleosome binding.
Cell Res., 24, 2014
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7LH9
 | | Crystal structure of BRPF2 PWWP domain in complex with DNA | | 分子名称: | Bromodomain-containing protein 1, DNA | | 著者 | Zhang, M, Lei, M, Qin, S, Dong, A, Yang, A, Li, Y, Loppnau, P, Hughes, T.R, Arrowsmith, C.H, Edwards, A.M, Min, J, Liu, J, Structural Genomics Consortium (SGC) | | 登録日 | 2021-01-21 | | 公開日 | 2021-02-17 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Crystal structure of the BRPF2 PWWP domain in complex with DNA reveals a different binding mode than the HDGF family of PWWP domains.
Biochim Biophys Acta Gene Regul Mech, 1864, 2021
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