6CKN

Crystal structure of an AF10 fragment

Summary for 6CKN

• Entry DOI: 10.2210/pdb6ckn/pdb
• Descriptor: Protein AF-10, UNKNOWN ATOM OR ION (2 entities in total)
• Functional Keywords: structural genomics, structural genomics consortium, sgc, dna binding protein
• Biological source: Homo sapiens (Human)
• Cellular location: Nucleus : P55197
• Total number of polymer chains: 2
• Total formula weight: 17583.63

Authors

Qin, S.,Tempel, W.,Li, Y.,Bountra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Structural Genomics Consortium (SGC) (deposition date: 2018-02-28, release date: 2018-03-21, Last modification date: 2018-04-18)

• Primary citation: Zhang, H.,Zhou, B.,Qin, S.,Xu, J.,Harding, R.,Tempel, W.,Nayak, V.,Li, Y.,Loppnau, P.,Dou, Y.,Min, J.; Structural and functional analysis of the DOT1L-AF10 complex reveals mechanistic insights into MLL-AF10-associated leukemogenesis.; Genes Dev., 32:341-346, 2018; PubMed: 29563185; DOI: 10.1101/gad.311639.118

Experimental method

X-RAY DIFFRACTION (2.49 Å)